Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Heidi K. Norton"'
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60498 (2013)
BackgroundCystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents. For this purpose, previous protein engineering efforts have focused on
Externí odkaz:
https://doaj.org/article/ca2be32f20cc460f80181c6f688ba77b
Autor:
Katelyn R. Titus, Danielle S. Bassett, Jesi Kim, Shi Gu, Jennifer E. Phillips-Cremins, Daniel J. Emerson, Heidi K. Norton, Harvey Huang
Publikováno v:
Nature Methods. 15:119-122
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs and looping interactions. Here, we describe 3DNetMod, a graph theory-based method for sensitive and accurate detection of chromatin domains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76469803c62a2e8529077abee92e181
https://doi.org/10.1038/nmeth.4560
https://doi.org/10.1038/nmeth.4560
Publikováno v:
The Journal of Cell Biology
Norton and Phillips-Cremins review the 3D architecture of the genome and discuss links between chromatin misfolding and human diseases.
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Mammalian genomes are folded into unique topological structures that undergo precise spatiotemporal restructu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de933b302113d6b61fde39c9473ee999
https://doi.org/10.1083/jcb.201611001
https://doi.org/10.1083/jcb.201611001
Autor:
Heidi K. Norton, Emily J. Shields, Gui Hu, Jonathan A. Beagan, Konrad Hochedlinger, Sarah C. Hsu, Effie Apostolou, Thomas G. Gilgenast, Job Dekker, Jennifer E. Phillips-Cremins, Victor G. Corces, Xiaowen Lyu, Zachary Plona, Jesi Kim
Publikováno v:
Cell Stem Cell. 18:611-624
Pluripotent genomes are folded in a topological hierarchy that reorganizes during differentiation. The extent to which chromatin architecture is reconfigured during somatic cell reprogramming is poorly understood. Here we integrate fine-resolution ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c54ffa12922cdebb50abbdf0be4a2c
https://doi.org/10.1016/j.stem.2016.04.004
https://doi.org/10.1016/j.stem.2016.04.004
Autor:
Danielle S. Bassett, Heidi K. Norton, Jesi Kim, Harvey Huang, Jennifer E. Phillips-Cremins, Daniel J. Emerson, Shi Gu
Mammalian genomes are folded in a hierarchy of topologically associating domains (TADs), subTADs and looping interactions. The nested nature of chromatin domains has rendered it challenging to identify a sensitive and specific metric for detecting su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79020775317f4bc90a4262ce36552639
https://doi.org/10.1101/089011
https://doi.org/10.1101/089011
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60498 (2013)
PLoS ONE
PLoS ONE
BackgroundCystine-knot miniproteins, also known as knottins, have shown great potential as molecular scaffolds for the development of targeted therapeutics and diagnostic agents. For this purpose, previous protein engineering efforts have focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7760d79612c981c1f69ea41acdcb5bbf
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23573262/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23573262/?tool=EBI