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pro vyhledávání: '"Heidi Ja Wallweber"'
Publikováno v:
eLife, Vol 7 (2018)
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present tw
Externí odkaz:
https://doaj.org/article/1250dbe478004f90b78369520c4b99fe
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Cytokines and interferons initiate intracellular signaling via receptor dimerization and activation of Janus kinases (JAKs). How JAKs structurally respond to changes in receptor conformation induced by ligand binding is not known. Here, we present tw
Autor:
Siao-Ping Tsai, Laura DeForge, Melissa A. Starovasnik, Deanne M. Compaan, Karen Billeci, Nathaniel C. Gordon, Robert F. Kelley, Heidi Ja Wallweber, Germaine Fuh, Chingwei V. Lee, Qian Gong, Sarah G. Hymowitz, Jian Ping Yin, Flavius Martin
Publikováno v:
Blood. 108(9)
BR3, which is expressed on all mature B cells, is a specific receptor for the B-cell survival and maturation factor BAFF (B-cell–activating factor belonging to the tumor necrosis factor [TNF] family). In order to investigate the consequences of tar