Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Heidi J, Elsaesser"'
Autor:
Ramy Gadalla, Babak Noamani, Bethany L. MacLeod, Russell J. Dickson, Mengdi Guo, Wenxi Xu, Sabelo Lukhele, Heidi J. Elsaesser, Albiruni R. Abdul Razak, Naoto Hirano, Tracy L. McGaha, Ben Wang, Marcus Butler, Cynthia J. Guidos, Pam S. Ohashi, Lillian L. Siu, David G. Brooks
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Flow cytometry is a widely applied approach for exploratory immune profiling and biomarker discovery in cancer and other diseases. However, flow cytometry is limited by the number of parameters that can be simultaneously analyzed, severely restrictin
Externí odkaz:
https://doaj.org/article/634646a4f4a340d1ae9adab5f45ea2de
Autor:
Laura M. Snell, Ivan Osokine, Douglas H. Yamada, Justin Rafael De la Fuente, Heidi J. Elsaesser, David G. Brooks
Publikováno v:
Cell Reports, Vol 16, Iss 12, Pp 3286-3296 (2016)
Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically l
Externí odkaz:
https://doaj.org/article/38afc539859f41e0a03d88bba858a20b
Autor:
Sabelo, Lukhele, Diala Abd, Rabbo, Mengdi, Guo, Jian, Shen, Heidi J, Elsaesser, Rene, Quevedo, Madeleine, Carew, Ramy, Gadalla, Laura M, Snell, Lawanya, Mahesh, M Teresa, Ciudad, Bryan E, Snow, Annick, You-Ten, Jillian, Haight, Andrew, Wakeham, Pamela S, Ohashi, Tak W, Mak, Weiguo, Cui, Tracy L, McGaha, David G, Brooks
Publikováno v:
Immunity. 55(12)
Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for immune activation, but also induce immune-suppressive feedback circuits that impede control of cancer growth. Here, we sought to determine how these opposing p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb8d4c32b046cb404482dc3e551e1fac
https://pubmed.ncbi.nlm.nih.gov/36370712
https://pubmed.ncbi.nlm.nih.gov/36370712
Autor:
Giselle M. Boukhaled, Ramy Gadalla, Heidi J. Elsaesser, Diala Abd-Rabbo, Rene Quevedo, S. Y. Cindy Yang, Mengdi Guo, Ben X. Wang, Babak Noamani, Diana Gray, Sally C. M. Lau, Kirsty Taylor, Kyaw Aung, Anna Spreafico, Aaron R. Hansen, Samuel D. Saibil, Naoto Hirano, Cynthia Guidos, Trevor J. Pugh, Tracy L. McGaha, Pamela S. Ohashi, Adrian G. Sacher, Marcus O. Butler, David G. Brooks
Publikováno v:
Nature immunology. 23(8)
Type I interferons (IFN-Is) are central regulators of anti-tumor immunity and responses to immunotherapy, but they also drive the feedback inhibition underlying therapeutic resistance. In the present study, we developed a mass cytometry approach to q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecb364ff53d9b9483fe0541a27e8c59
https://pubmed.ncbi.nlm.nih.gov/35864245
https://pubmed.ncbi.nlm.nih.gov/35864245
Autor:
Giselle M Boukhaled, Ramy Gadalla, Heidi J. Elsaesser, Adrian Sacher, Marcus O Butler, David G. Brooks
Publikováno v:
The Journal of Immunology. 208:180.03-180.03
Type I interferons (IFN-Is) are paradoxically associated with both the success and failure of immune checkpoint blockade (ICB), with increased inflammation in the tumor associated with better response. To understand how IFN-Is modulate the immune res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e078ad3f515103ea89585a959cd58803
https://doi.org/10.4049/jimmunol.208.supp.180.03
https://doi.org/10.4049/jimmunol.208.supp.180.03
Autor:
Laura M, Snell, Wenxi, Xu, Diala, Abd-Rabbo, Giselle, Boukhaled, Mengdi, Guo, Bethany L, Macleod, Heidi J, Elsaesser, Kebria, Hezaveh, Nirmin, Alsahafi, Sabelo, Lukhele, Sara, Nejat, Ramanandan, Prabhakaran, Slava, Epelman, Tracy L, McGaha, David G, Brooks
Publikováno v:
Nat Immunol
Inhibiting PD-1:PD-L1 signaling has transformed therapeutic immune restoration. CD4(+) T cells sustain immunity in chronic infections and cancer, yet little is known about how PD-1 signaling modulates CD4(+) helper T (T(H)) cell responses or the abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::828b63e1cb80f691d1a66c712b315fa5
https://pubmed.ncbi.nlm.nih.gov/34795443
https://pubmed.ncbi.nlm.nih.gov/34795443
Autor:
Bethany L Macleod, Russell Dickson, Kebria Hezaveh, Heidi J Elsaesser, Cynthia J Guidos, David G Brooks
Publikováno v:
The Journal of Immunology. 202:197.10-197.10
Chronic viruses such as HIV and hepatitis are a major health concern worldwide. As an organ constantly exposed to the external environment, the gastrointestinal tract (GIT) must constantly balance suppressive and inflammatory immunity, making it an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2336cf90686d5c891d74cd9ae1531509
https://doi.org/10.4049/jimmunol.202.supp.197.10
https://doi.org/10.4049/jimmunol.202.supp.197.10
Autor:
Xavier, Clemente-Casares, Siyavash, Hosseinzadeh, Iulia, Barbu, Sarah A, Dick, Jillian A, Macklin, Yiming, Wang, Abdul, Momen, Crystal, Kantores, Laura, Aronoff, Maylis, Farno, Tiffany M, Lucas, Joan, Avery, Dorrin, Zarrin-Khat, Heidi J, Elsaesser, Babak, Razani, Kory J, Lavine, Mansoor, Husain, David G, Brooks, Clinton S, Robbins, Myron, Cybulsky, Slava, Epelman
Publikováno v:
Immunity. 47(5)
Innate and adaptive immune cells modulate heart failure pathogenesis during viral myocarditis, yet their identities and functions remain poorly defined. We utilized a combination of genetic fate mapping, parabiotic, transcriptional, and functional an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e5ddaf58e21297e1dc722c9d5eef566
https://pubmed.ncbi.nlm.nih.gov/29166591
https://pubmed.ncbi.nlm.nih.gov/29166591
Autor:
Eugene J. Gillespie, Chi-Lee C. Ho, Kavitha Balaji, Daniel L. Clemens, Gang Deng, Yao E. Wang, Heidi J. Elsaesser, Batcha Tamilselvam, Amandeep Gargi, Shandee D. Dixon, Bryan France, Brian T. Chamberlain, Steven R. Blanke, Genhong Cheng, Juan Carlos de la Torre, David G. Brooks, Michael E. Jung, John Colicelli, Robert Damoiseaux, Kenneth A. Bradley
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 50
Gillespie, EJ; Ho, CLC; Balaji, K; Clemens, DL; Deng, G; Wang, YE; et al.(2013). Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences of the United States of America, 110(50). doi: 10.1073/pnas.1302334110. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4vf3g2sj
Gillespie, EJ; Ho, CLC; Balaji, K; Clemens, DL; Deng, G; Wang, YE; et al.(2013). Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses. Proceedings of the National Academy of Sciences of the United States of America, 110(50). doi: 10.1073/pnas.1302334110. UCLA: Retrieved from: http://www.escholarship.org/uc/item/4vf3g2sj
Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular entry requires trafficking to an acidified endosome,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a951ab6a01af6d1009c6744f539fd12
https://escholarship.org/uc/item/4vf3g2sj
https://escholarship.org/uc/item/4vf3g2sj
