Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Heidi I L, Jacobs"'
Autor:
Rory Boyle, Diana L. Townsend, Hannah M. Klinger, Catherine E. Scanlon, Ziwen Yuan, Gillian T. Coughlan, Mabel Seto, Zahra Shirzadi, Wai-Ying Wendy Yau, Roos J. Jutten, Christoph Schneider, Michelle E. Farrell, Bernard J. Hanseeuw, Elizabeth C. Mormino, Hyun-Sik Yang, Kathryn V. Papp, Rebecca E. Amariglio, Heidi I. L. Jacobs, Julie C. Price, Jasmeer P. Chhatwal, Aaron P. Schultz, Michael J. Properzi, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Timothy J. Hohman, Michael C. Donohue, Rachel F. Buckley, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-16 (2024)
Abstract Background Leveraging Alzheimer’s disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class mixture modeling, adju
Externí odkaz:
https://doaj.org/article/533e6b89a4fd4deeb58b8bf4d29de93c
Autor:
Nina Engels-Domínguez, Elouise A. Koops, Stephanie Hsieh, Emma E. Wiklund, Aaron P. Schultz, Joost M. Riphagen, Prokopis C. Prokopiou, Bernard J. Hanseeuw, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Autopsy work indicates that the widely-projecting noradrenergic pontine locus coeruleus (LC) is among the earliest regions to accumulate hyperphosphorylated tau, a neuropathological Alzheimer’s disease (AD) hallmark. This early
Externí odkaz:
https://doaj.org/article/1a2a23bb5bfe4f028d41e04abb34676d
Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging
Autor:
Ibai Diez, Laura Ortiz-Terán, Thomas S. C. Ng, Mark W. Albers, Gad Marshall, William Orwig, Chan-mi Kim, Elisenda Bueichekú, Victor Montal, Jonas Olofsson, Patrizia Vannini, Georges El Fahkri, Reisa Sperling, Keith Johnson, Heidi I. L. Jacobs, Jorge Sepulcre
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD). In this study, we used
Externí odkaz:
https://doaj.org/article/53baab9f774f44ed85ed879dfc0ad4b7
Autor:
Alexandre Berger, Ekaterina Koshmanova, Elise Beckers, Roya Sharifpour, Ilenia Paparella, Islay Campbell, Nasrin Mortazavi, Fermin Balda, Yeo-Jin Yi, Laurent Lamalle, Laurence Dricot, Christophe Phillips, Heidi I. L. Jacobs, Puneet Talwar, Riëm El Tahry, Siya Sherif, Gilles Vandewalle
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
IntroductionThe brainstem locus coeruleus (LC) influences a broad range of brain processes, including cognition. The so-called LC contrast is an accepted marker of the integrity of the LC that consists of a local hyperintensity on specific Magnetic R
Externí odkaz:
https://doaj.org/article/ddbee8627aee4c61887c99d0abf30e8a
Autor:
Julian Dronse, Anna Ohndorf, Nils Richter, Gérard N. Bischof, Ronja Fassbender, Qumars Behfar, Hannes Gramespacher, Kim Dillen, Heidi I. L. Jacobs, Juraj Kukolja, Gereon R. Fink, Oezguer A. Onur
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
ObjectiveElevated cortisol levels have been frequently reported in Alzheimer’s disease (AD) and linked to brain atrophy, especially of the hippocampus. Besides, high cortisol levels have been shown to impair memory performance and increase the risk
Externí odkaz:
https://doaj.org/article/5bc73711928c463aad9802979a2bc8de
Autor:
Prokopis C. Prokopiou, Nina Engels-Domínguez, Kathryn V. Papp, Matthew R. Scott, Aaron P. Schultz, Christoph Schneider, Michelle E. Farrell, Rachel F. Buckley, Yakeel T. Quiroz, Georges El Fakhri, Dorene M. Rentz, Reisa A. Sperling, Keith A. Johnson, Heidi I. L. Jacobs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Older individuals exhibiting diminished function of the locus coeruleus while learning new information show faster cognitive decline that is typical for Alzheimer’s disease.
Externí odkaz:
https://doaj.org/article/064e0e4a05864dea8910777843fb04ad
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-10 (2021)
Abstract Background The brainstem locus coeruleus (LC) constitutes the intersection of the initial pathophysiological processes of Alzheimer’s disease (AD) and sleep-wake dysregulation in the preclinical stages of the disease. However, the interpla
Externí odkaz:
https://doaj.org/article/65b7664cf4534b47bc5a7c16561fca65
Autor:
Justin S. Sanchez, Bernard J. Hanseeuw, Francisco Lopera, Reisa A. Sperling, Ana Baena, Yamile Bocanegra, David Aguillon, Edmarie Guzmán-Vélez, Enmanuelle Pardilla-Delgado, Liliana Ramirez-Gomez, Clara Vila-Castelar, Jairo E. Martinez, Joshua T. Fox-Fuller, Claudia Ramos, Martin Ochoa-Escudero, Sergio Alvarez, Heidi I. L. Jacobs, Aaron P. Schultz, Jennifer R. Gatchel, J. Alex Becker, Samantha R. Katz, Danielle V. Mayblyum, Julie C. Price, Eric M. Reiman, Keith A. Johnson, Yakeel T. Quiroz
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Background Neuroimaging studies of autosomal dominant Alzheimer’s disease (ADAD) enable characterization of the trajectories of cerebral amyloid-β (Aβ) and tau accumulation in the decades prior to clinical symptom onset. Longitudinal rat
Externí odkaz:
https://doaj.org/article/6c7078c506f2419da4f7a232e1dfe210
Autor:
Adam D. Farmer, Adam Strzelczyk, Alessandra Finisguerra, Alexander V. Gourine, Alireza Gharabaghi, Alkomiet Hasan, Andreas M. Burger, Andrés M. Jaramillo, Ann Mertens, Arshad Majid, Bart Verkuil, Bashar W. Badran, Carlos Ventura-Bort, Charly Gaul, Christian Beste, Christopher M. Warren, Daniel S. Quintana, Dorothea Hämmerer, Elena Freri, Eleni Frangos, Eleonora Tobaldini, Eugenijus Kaniusas, Felix Rosenow, Fioravante Capone, Fivos Panetsos, Gareth L. Ackland, Gaurav Kaithwas, Georgia H. O'Leary, Hannah Genheimer, Heidi I. L. Jacobs, Ilse Van Diest, Jean Schoenen, Jessica Redgrave, Jiliang Fang, Jim Deuchars, Jozsef C. Széles, Julian F. Thayer, Kaushik More, Kristl Vonck, Laura Steenbergen, Lauro C. Vianna, Lisa M. McTeague, Mareike Ludwig, Maria G. Veldhuizen, Marijke De Couck, Marina Casazza, Marius Keute, Marom Bikson, Marta Andreatta, Martina D'Agostini, Mathias Weymar, Matthew Betts, Matthias Prigge, Michael Kaess, Michael Roden, Michelle Thai, Nathaniel M. Schuster, Nicola Montano, Niels Hansen, Nils B. Kroemer, Peijing Rong, Rico Fischer, Robert H. Howland, Roberta Sclocco, Roberta Sellaro, Ronald G. Garcia, Sebastian Bauer, Sofiya Gancheva, Stavros Stavrakis, Stefan Kampusch, Susan A. Deuchars, Sven Wehner, Sylvain Laborde, Taras Usichenko, Thomas Polak, Tino Zaehle, Uirassu Borges, Vanessa Teckentrup, Vera K. Jandackova, Vitaly Napadow, Julian Koenig
Publikováno v:
Frontiers in Human Neuroscience, Vol 14 (2021)
Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation (tVNS) across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular bra
Externí odkaz:
https://doaj.org/article/559b65cb001b4e368330a755e0899b33
Autor:
Franziska Rienäcker, Pascal W. M. Van Gerven, Heidi I. L. Jacobs, Judith Eck, Caroline M. Van Heugten, Maria J. S. Guerreiro
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Age-related deficits in selective attention have been demonstrated to depend on the sensory modality through which targets and distractors are presented. Some of these investigations suggest a specific impairment of cross-modal auditory selective att
Externí odkaz:
https://doaj.org/article/dcfe7f23aa534909a0853d77965c4c10