Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Heidi Hongisto"'
Autor:
Farhana Jahan, Leena Penna, Annu Luostarinen, Laurens Veltman, Heidi Hongisto, Kaarina Lähteenmäki, Sabine Müller, Seppo Ylä-Herttuala, Matti Korhonen, Kim Vettenranta, Anita Laitinen, Urpu Salmenniemi, Erja Kerkelä
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Natural killer (NK) cells are a promising allogeneic immunotherapy option due to their natural ability to kill tumor cells, and due to their apparent safety. This study describes the development of a GMP-compliant manufacturing protocol for
Externí odkaz:
https://doaj.org/article/b4949fb2a86c4f2ea2ea182932cf3e7c
Autor:
Taina Viheriälä, Heidi Hongisto, Lyydia Saari, Marika Oksanen, Tanja Ilmarinen, Suvi Väärämäki, Hannu Uusitalo, Pasi Nevalainen, Heli Skottman
Publikováno v:
Journal of Ophthalmology, Vol 2024 (2024)
Pseudoxanthoma elasticum (PXE) is a rare metabolic disease with autosomal recessive inheritance. The manifestation in PXE is represented by retinal complications, pseudoxanthomas of the skin folding areas, and arterial calcification. The retinal comp
Externí odkaz:
https://doaj.org/article/61ec2863cb8f482a86dc87d7aaff743e
Autor:
Taina Viheriälä, Heidi Hongisto, Juhana Sorvari, Heli Skottman, Soile Nymark, Tanja Ilmarinen
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Transplantation of human pluripotent stem cell-derived retinal pigment epithelium (RPE) is an urgently needed treatment for the cure of degenerative diseases of the retina. The transplanted cells must tolerate cellular stress caus
Externí odkaz:
https://doaj.org/article/ed01c9899b0d4fbfb6584065b4248cb5
Autor:
Zengping Liu, Tanja Ilmarinen, Gavin S. W. Tan, Heidi Hongisto, Edmund Y. M. Wong, Andrew S. H. Tsai, Sami Al-Nawaiseh, Graham E. Holder, Xinyi Su, Veluchamy Amutha Barathi, Heli Skottman, Boris V. Stanzel
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract Background Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell replacement therapy but often lack standardized cell production and live-cell shipment logistics as well as rigorous analyses of surgical proced
Externí odkaz:
https://doaj.org/article/79af98e8d625467a8668cca14fc1c485
Autor:
Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto, Heli Skottman
Publikováno v:
Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-15 (2019)
Abstract Background The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial renewal. However, the lac
Externí odkaz:
https://doaj.org/article/cf9a643032524b65a5f2b14a53ee5aff
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 14, Iss 3, p 595 (2022)
The published article [...]
Externí odkaz:
https://doaj.org/article/fa8a6a9506b34194851652778e0765fe
Publikováno v:
Stem Cell Research & Therapy, Vol 8, Iss 1, Pp 1-15 (2017)
Abstract Background Human pluripotent stem cells (hPSCs) provide a promising cell source for ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture and differentiation protocols. We aimed to develop a xeno- and feede
Externí odkaz:
https://doaj.org/article/ef58731dbfc8448bb4a62a1a42089600
Autor:
Maria Hytti, Eveliina Korhonen, Heidi Hongisto, Kai Kaarniranta, Heli Skottman, Anu Kauppinen
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 13, p 6800 (2021)
Inflammation is a key underlying factor of age-related macular degeneration (AMD) and inflammasome activation has been linked to disease development. Induced pluripotent stem-cell-derived retinal pigment epithelial cells (iPSC-RPE) are an attractive
Externí odkaz:
https://doaj.org/article/f5eee938bd9a4ace8b8185a1eae214f8
Autor:
Heidi Hongisto, Antti Jylhä, Janika Nättinen, Jochen Rieck, Tanja Ilmarinen, Zoltán Veréb, Ulla Aapola, Roger Beuerman, Goran Petrovski, Hannu Uusitalo, Heli Skottman
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) provide an unlimited cell source for retinal cell replacement therapies. Clinical trials using hESC-RPE to treat diseases such as age-related macular degeneration
Externí odkaz:
https://doaj.org/article/5dfb8d40194e4fada1a0660c2d028f4e
Autor:
Laura Hellinen, Heidi Hongisto, Eva Ramsay, Kai Kaarniranta, Kati-Sisko Vellonen, Heli Skottman, Marika Ruponen
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 176 (2020)
The retinal pigment epithelial (RPE) cell monolayer forms the outer blood−retinal barrier and has a crucial role in ocular pharmacokinetics. Although several RPE cell models are available, there have been no systematic comparisons of their barrier
Externí odkaz:
https://doaj.org/article/8ee02da0d3944372a3092b7c49eff940