Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Heidi Ho"'
Autor:
Dominik F. Draxler, Gryselda Hanafi, Saffanah Zahra, Fiona McCutcheon, Heidi Ho, Charithani B. Keragala, Zikou Liu, David Daly, Thomas Painter, Sophia Wallace, Magdalena Plebanski, Paul S. Myles, Robert L. Medcalf
Publikováno v:
Thrombosis Journal, Vol 20, Iss 1, Pp 1-16 (2022)
Abstract Background Tranexamic acid (TXA) is an antifibrinolytic agent frequently used in elective surgery to reduce blood loss. We recently found it also acts as a potent immune-modulator in patients undergoing cardiac surgery. Methods Patients unde
Externí odkaz:
https://doaj.org/article/9acad31c0f7e4f36a4f5b7e6602bff63
Autor:
Charithani B. Keragala, Trent M. Woodruff, Zikou Liu, Be'eri Niego, Heidi Ho, Zoe McQuilten, Robert L. Medcalf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Background: Tissue-type plasminogen activator (t-PA) has been the mainstay of therapeutic thrombolysis for patients with acute ischaemic stroke (AIS). However, t-PA can cause devastating intracerebral hemorrhage. t-PA can also influence the CNS in pa
Externí odkaz:
https://doaj.org/article/e1ae5ef9386e4bcfa8235cdb4995d93e
Autor:
Thomas Lillicrap, Charithani B. Keragala, Dominik F. Draxler, Jilly Chan, Heidi Ho, Stevi Harman, Be'eri Niego, Elizabeth Holliday, Christopher R. Levi, Carlos Garcia-Esperon, Neil Spratt, Prajwal Gyawali, Andrew Bivard, Mark W. Parsons, Joan Montaner, Alejandro Bustamante, Israel Fernandez Cadenas, Geoffrey Cloud, Jane M. Maguire, Lisa Lincz, Timothy Kleinig, John Attia, Simon Koblar, Monica Anne Hamilton-Bruce, Philip Choi, Bradford B. Worrall, Robert L. Medcalf
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Rationale: More than half of patients who receive thrombolysis for acute ischaemic stroke fail to recanalize. Elucidating biological factors which predict recanalization could identify therapeutic targets for increasing thrombolysis success.Hypothesi
Externí odkaz:
https://doaj.org/article/86906486acd54bac865705d696765ecb
Publikováno v:
Fluids and Barriers of the CNS, Vol 14, Iss 1, Pp 1-11 (2017)
Abstract Background Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstac
Externí odkaz:
https://doaj.org/article/5cc7a82c01434da8a40932debbe083aa
Autor:
Maria Daglas, Dominik F. Draxler, Heidi Ho, Fiona McCutcheon, Adam Galle, Amanda E. Au, Pia Larsson, Julia Gregory, Frank Alderuccio, Maithili Sashindranath, Robert L. Medcalf
Publikováno v:
Cell Reports, Vol 29, Iss 5, Pp 1178-1191.e6 (2019)
Summary: Traumatic brain injury (TBI) leaves many survivors with long-term disabilities. A prolonged immune response in the brain may cause neurodegeneration, resulting in chronic neurological disturbances. In this study, using a TBI mouse model, we
Externí odkaz:
https://doaj.org/article/b8a4fd86be32435496abc3f41d48850c
Autor:
Dominik F. Draxler, Felix Lee, Heidi Ho, Charithani B. Keragala, Robert L. Medcalf, Be'eri Niego
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Introduction: Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS, p
Externí odkaz:
https://doaj.org/article/3a13fe7218b64f59af4f5f83ad3137d9
Autor:
Karen N Borschmann, Sarah S Rewell, Sandra Iuliano, Ali Ghasem-Zadeh, Rachel A Davey, Heidi Ho, Peta N Skeers, Julie Bernhardt, David W Howells
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172889 (2017)
BACKGROUND:Immobility and neural damage likely contribute to accelerated bone loss after stroke, and subsequent heightened fracture risk in humans. OBJECTIVE:To investigate the skeletal effect of middle cerebral artery occlusion (MCAo) stroke in rats
Externí odkaz:
https://doaj.org/article/0d661a714f5c44cabf44f68376a0ef1d
Autor:
Lisa Cm Dahl, Zeyad Nasa, JieYu Chung, Be'eri Niego, Volga Tarlac, Heidi Ho, Adam Galle, Steven Petratos, Jae Young Lee, Frank Alderuccio, Robert L Medcalf
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0158653 (2016)
Tissue type plasminogen activator (t-PA) has been implicated in the development of multiple sclerosis (MS) and in rodent models of experimental autoimmune encephalomyelitis (EAE). We show that levels of t-PA mRNA and activity are increased ~4 fold in
Externí odkaz:
https://doaj.org/article/77a9c89bebad43b3988a9d2755f2ba76
Autor:
Jason S. Palazzolo, Anukreity Ale, Heidi Ho, Shweta Jagdale, Brad R. S. Broughton, Robert L. Medcalf, David K. Wright, Karen Alt, Christoph E. Hagemeyer, Be’eri Niego
Publikováno v:
Blood Advances. 7:561-574
Thrombolysis with tissue-type plasminogen activator (tPA) remains the main treatment for acute ischemic stroke. Nevertheless, tPA intervention is limited by a short therapeutic window, low recanalization rates, and a risk of intracranial hemorrhage (
Autor:
Una Stenberg, Lydia Westfal, Andreas Dybesland Rosenberger, Kristin Ørstavik, Maria Flink, Heidi Holmen, Silje Systad, Karl Fredrik Westermann, Gry Velvin
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background The ability to find, understand, appraise and utilise health information is crucial among individuals living with rare disorders. The aim of this study was to give a comprehensive overview of the literature on health literacy in a
Externí odkaz:
https://doaj.org/article/1badadfbf1e44fcb8553e0900861e280