Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Heidi H. Wiener"'
Autor:
Heidi H. Wiener, Ian M. Ahearn, Yong Zhou, Mark R. Philips, Mo Zhou, John F. Hancock, Caroline Liot, Wenjuan Su
Publikováno v:
The Journal of Cell Biology
Mutated N-Ras causes leukemia and melanoma when properly delivered to cellular membranes. Here, VPS35, a component of the retromer, is shown to carry N-Ras from one membrane compartment to another. Thus, VPS35 may be a target for anticancer drug disc
Publikováno v:
Proceedings of the National Academy of Sciences. 103:9045-9050
Compartment-specific Ras signaling is an emerging paradigm that may explain the multiplex outputs from a single GTPase. The fission yeast, Schizosaccharomyces pombe, affords a simple system in which to study Ras signaling because it has a single Ras
Autor:
Adam Mor, Ignacio Pérez de Castro, Chi Li, Brian O. Bodemann, Michael J. Soskis, Adrienne D. Cox, Shahryar G Saba, Duke Yim, John Miura, Ian M. Ahearn, Adam Fein, Trever G. Bivona, Mark R. Philips, Steven E. Quatela, Latasha Wright, Heidi H. Wiener, Craig B. Thompson
Publikováno v:
Molecular Cell. 21:481-493
K-Ras associates with the plasma membrane (PM) through farnesylation that functions in conjunction with an adjacent polybasic sequence. We show that phosphorylation by protein kinase C (PKC) of S181 within the polybasic region promotes rapid dissocia
Autor:
Guoming Ou, Kristina Loukeris, Michael H. Pillinger, Heidi H. Wiener, Vi K. Chiu, Victoria Dinsell, Mark R. Philips, Joseph Silletti
Publikováno v:
Journal of Biological Chemistry. 279:7346-7352
Post-translational modification of Ras proteins includes prenylcysteine-directed carboxyl methylation. Because Ras participates in Erk activation by epidermal growth factor (EGF), we tested whether Ras methylation regulates Erk activation. EGF stimul
Autor:
Anna Wredenberg, Håkan Westerblad, Steven J. Burden, Anders Oldfors, Caroline Graff, Nils-Göran Larsson, Heidi H. Wiener, Rolf Wibom, Hans Wilhelmsson
Publikováno v:
Proceedings of the National Academy of Sciences. 99:15066-15071
We have generated an animal model for mitochondrial myopathy by disrupting the gene for mitochondrial transcription factor A ( Tfam ) in skeletal muscle of the mouse. The knockout animals developed a myopathy with ragged-red muscle fibers, accumulati
Autor:
Trever G. Bivona, Joseph Silletti, Heidi H. Wiener, Mark R. Philips, Ronald L. Johnson, J. Bernard Sajous, Vi K. Chiu, Adrienne D. Cox, Angela Hach
Publikováno v:
Nature Cell Biology. 4:343-350
Current models evoke the plasma membrane (PM) as the exclusive platform from which Ras regulates signalling. We developed a fluorescent probe that reports where and when Ras is activated in living cells. We show that oncogenic H-Ras and N-Ras engage
Autor:
Trever G. Bivona, Joseph Silletti, Ian M. Ahearn, Heidi H. Wiener, Vi K. Chiu, Mark R. Philips
Publikováno v:
Bivona, TG; Wiener, HH; Ahearn, IM; Silletti, J; Chiu, VK; & Philips, MR. (2004). Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.. The Journal of cell biology, 164(3), 461-470. doi: 10.1083/jcb.200311093. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8z97q3j2
The Journal of Cell Biology
The Journal of Cell Biology
Rap1 and Ras are closely related GTPases that share some effectors but have distinct functions. We studied the subcellular localization of Rap1 and its sites of activation in living cells. Both GFP-tagged Rap1 and endogenous Rap1 were localized to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d298d89d8e0d2605141671f7264f6dcc
http://www.escholarship.org/uc/item/8z97q3j2
http://www.escholarship.org/uc/item/8z97q3j2
Publikováno v:
genesis. 26:165-166
It is often difficult to study the function of genes that are widely expressed, because their critical function in one tissue can complicate or preclude study of their role in other tissues. Several lines of evidence support the idea that neuregulin
Autor:
Zhou M; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016., Wiener H; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016., Su W; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016., Zhou Y; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030., Liot C; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016., Ahearn I; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016., Hancock JF; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX 77030., Philips MR; Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016 philim01@nyumc.org.
Publikováno v:
The Journal of cell biology [J Cell Biol] 2016 Aug 15; Vol. 214 (4), pp. 445-58. Date of Electronic Publication: 2016 Aug 08.
Autor:
Onken B; Department of Molecular and Cell Biology, The Breast Center, Baylor College of Medicine, 1 Baylor Plaza, BCM 600, Houston, TX 77030, USA., Wiener H, Philips MR, Chang EC
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Jun 13; Vol. 103 (24), pp. 9045-50. Date of Electronic Publication: 2006 Jun 05.