Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions

Autor: Heidi H. Pak, Allison N. Grossberg, Rachel R. Sanderfoot, Reji Babygirija, Cara L. Green, Mikaela Koller, Monika Dzieciatkowska, Daniel A. Paredes, Dudley W. Lamming

Publikováno v: Cell Reports, Vol 43, Iss 9, Pp 114663- (2024)

Summary: Calorie restriction (CR) extends lifespan and healthspan in diverse species. Comparing ad libitum- and CR-fed mice is challenging due to their significantly different feeding patterns, with CR-fed mice consuming their daily meal in 2 h and t

Externí odkaz: https://doaj.org/article/5fe82deba8cf47e18de23ce721f3e896

Fasting drives the metabolic, molecular and geroprotective effects of a calorie-restricted diet in mice

Autor: John M. Denu, Nicole E. Richardson, Spencer A. Haws, Shany E. Yang, Heidi H. Pak, Cara L Green, Dudley W. Lamming, Chi-Liang Eric Yen, Victor M. Darley-Usmar, Lindsey Bray, Mitchell T. Lavarias, Michelle Sonsalla, Stephen Barnes, Jianhua Zhang, Sabrina N Dumas, Michelle S. Johnson, Mikaela Koller

Publikováno v: Nature Metabolism. 3:1327-1341

Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been shown that fasting for a portion of each day has metabolic benefits and promotes lifespan. These findings complicate the interpretation of rodent CR studies, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::330794b531bf15345c931ebbe63cc946
https://doi.org/10.1038/s42255-021-00466-9

Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

Autor: Cara L. Green, Michaela E. Trautman, Reji Babygirija, Raghav Jain, Krittisak Chaiyakul, Heidi H. Pak, Anneliese Bleicher, Grace Novak, Michelle M. Sonsalla, Chung-Yang Yeh, Mariah F. Calubag, Teresa T. Liu, Victoria Flores, Sarah Newman, Will A. Ricke, Kristina A. Matkowskyj, Irene M. Ong, Judith Simcox, Dudley W. Lamming

Low protein (LP) diets promote health and longevity in diverse species. Although the precise components of an LP diet that mediate its beneficial effects have not been defined, reducing dietary levels of the three branched-chain amino acids (BCAAs) l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bff1b4e35c14eedbabe26545f645e164
https://doi.org/10.1101/2022.10.06.511051

FGF21 has a sex-specific role in calorie-restriction-induced beiging of white adipose tissue in mice

Autor: Mariah F. Calubag, Ismail Ademi, Chung-Yang Yeh, Reji Babygirija, Alyssa M. Bhoopat, Ildiko Kasza, Michelle M. Sonsalla, Cara L. Green, Heidi H. Pak, Dudley W. Lamming

Publikováno v: Aging Biol

Calorie restriction (CR) promotes healthspan and extends the lifespan of diverse organisms, including mice, and there is intense interest in understanding the molecular mechanisms by which CR functions. Some studies have demonstrated that CR induces

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe6bf38fc1b4aecdcf0f3ebce769b53
https://doi.org/10.1101/2022.07.29.501882

ARDD 2020: from aging mechanisms to interventions

Autor: Wei Wu He, Brenna Osborne, Dario Riccardo Valenzano, Lene Juel Rasmussen, Rafael de Cabo, Dudley W. Lamming, Jim Mellon, Evandro Fei Fang, Marсo Demaria, Aubrey de Grey, Andrey A. Parkhitko, Lei Zhang, Sergey Young, Nanna MacAulay, Vera Gorbunova, Martin Borch Jensen, Jonas T. Treebak, Alexey Moskalev, Judith Campisi, Anais Franco-Romero, Nuno Raimundo, Collin Y. Ewald, Morten Scheibye-Knudsen, Riekelt H. Houtkooper, Majken K. Jensen, Luigi Ferrucci, Kai Fu Lee, Jan H.J. Hoeijmakers, Eva Hoffmann, Carolina Reis, Søren Brunak, Thomas A. Rando, David A. Sinclair, David J. Glass, Daniela Bakula, Adam Freund, Pam R. Taub, Brian K. Kennedy, Yousin Suh, Moustapha Kassem, Kotb Abdelmohsen, Polina Mamoshina, Björn Schumacher, Debra Toiber, Ana Maria Cuervo, Gerard Karsenty, Peter L.J. de Keizer, Laura J. Niedernhofer, Ieva Bagdonaite, Christian G. Riedel, Steve Horvath, Richard G. A. Faragher, Carlos G. Silva-García, Vadim N. Gladyshev, Alice E. Kane, Anastasia Georgievskaya, Eric Verdin, Marte Molenaars, Nir Barzilai, Filipe Cabreiro, Heidi H. Pak, Pénélope Andreux, Garik Mkrtchyan, Alex Zhavoronkov, Andreas Mund, Jan Vijg

Publikováno v: Aging (Albany NY)
Mkrtchyan, G V, Abdelmohsen, K, Andreux, P, Bagdonaite, I, Barzilai, N, Brunak, S, Cabreiro, F, de Cabo, R, Campisi, J, Cuervo, A M, Demaria, M, Ewald, C Y, Fang, E F, Faragher, R, Ferrucci, L, Freund, A, Silva-García, C G, Georgievskaya, A, Gladyshev, V N, Glass, D J, Gorbunova, V, de Grey, A, He, W-W, Hoeijmakers, J, Hoffmann, E, Horvath, S, Houtkooper, R H, Jensen, M K, Jensen, M B, Kane, A, Kassem, M, de Keizer, P, Kennedy, B, Karsenty, G, Lamming, D W, Lee, K-F, MacAulay, N, Mamoshina, P, Mellon, J, Molenaars, M, Moskalev, A, Mund, A, Niedernhofer, L, Osborne, B, Pak, H H, Parkhitko, A, Raimundo, N, Rando, T A, Rasmussen, L J, Reis, C, Riedel, C G, Franco-Romero, A, Schumacher, B, Sinclair, D A, Suh, Y, Taub, P R, Toiber, D, Treebak, J T, Valenzano, D R, Verdin, E, Vijg, J, Young, S, Zhang, L, Bakula, D, Zhavoronkov, A & Scheibye-Knudsen, M 2020, ' ARDD 2020 : from aging mechanisms to interventions ', Aging, vol. 12, no. 24, pp. 24484-24503 . https://doi.org/10.18632/aging.202454
Aging, 12(24), 24486-24503. Impact Journals LLC
Aging, vol 12, iss 24
Aging, 12 (24)
Aging, 12(24), 24486-24503. US Administration on Aging

Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3497e8366f86e4471317db5f9f7af5f9