Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Heidi E. Steiner"'
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 10, Pp 2303-2315 (2022)
Abstract Pharmacomicrobiomic studies investigate drug‐microbiome interactions, such as the effect of microbial variation on drug response and disposition. Studying and understanding the interactions between the gut microbiome and drugs is becoming
Externí odkaz:
https://doaj.org/article/1fe4762d9a4c4a50bc064d8fee72ca21
Autor:
Chloe Grace, Marti M. Larriva, Heidi E. Steiner, Srujitha Marupuru, Patrick J. Campbell, Hayley Patterson, Cheryl D. Cropp, Dorothy Quinn, Walter Klimecki, David E. Nix, Terri Warholak, Jason H. Karnes
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2532-2543 (2021)
Abstract Personal genomic educational testing (PGET) has been suggested as a strategy to improve student learning for pharmacogenomics (PGx), but no randomized studies have evaluated PGET’s educational benefit. We investigated the effect of PGET on
Externí odkaz:
https://doaj.org/article/1d75d7bdfb374057ad8bbeb7c5039e99
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Heparin-induced thrombocytopenia (HIT) is an unpredictable, complex, immune-mediated adverse drug reaction associated with a high mortality. Despite decades of research into HIT, fundamental knowledge gaps persist regarding HIT likely due to the comp
Externí odkaz:
https://doaj.org/article/0dde7cc44f2c4dd9a853d9eacf905e03
Autor:
Heidi E. Steiner, Jason B. Giles, Hayley Knight Patterson, Jianglin Feng, Nihal El Rouby, Karla Claudio, Leiliane Rodrigues Marcatto, Leticia Camargo Tavares, Jubby Marcela Galvez, Carlos-Alberto Calderon-Ospina, Xiaoxiao Sun, Mara H. Hutz, Stuart A. Scott, Larisa H. Cavallari, Dora Janeth Fonseca-Mendoza, Jorge Duconge, Mariana Rodrigues Botton, Paulo Caleb Junior Lima Santos, Jason H. Karnes
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Populations used to create warfarin dose prediction algorithms largely lacked participants reporting Hispanic or Latino ethnicity. While previous research suggests nonlinear modeling improves warfarin dose prediction, this research has mainly focused
Externí odkaz:
https://doaj.org/article/9d45d0abee954be3a6a4042265bb861d
Autor:
Jason B. Giles, Heidi E. Steiner, Jerome Rollin, Christian M. Shaffer, Yukihide Momozawa, Taisei Mushiroda, Chihiro Inai, Kathleen Selleng, Thomas Thiele, Claire Pouplard, Nancy M. Heddle, Michiaki Kubo, Elise C. Miller, Kiana L. Martinez, Elizabeth J. Phillips, Theodore E. Warkentin, Yves Gruel, Andreas Greinacher, Dan M. Roden, Jason H. Karnes
Publikováno v:
Blood Advances. 6:4137-4146
Heparin, a widely used anticoagulant, carries the risk of an antibody-mediated adverse drug reaction, heparin-induced thrombocytopenia (HIT). A subset of heparin-treated patients produces detectable levels of antibodies against complexes of heparin b
Autor:
Hayley Knight, Heidi E. Steiner, Jason H. Karnes, Kevin Gee, Jason B. Giles, Bonnie L. Hurwitz
Publikováno v:
Pharmacotherapy
Response to cardiovascular drugs can vary greatly between individuals, and the role of the microbiome in this variability is being increasingly appreciated. Recent evidence indicates that bacteria and other microbes are responsible for direct and ind
Autor:
Heidi E. Steiner, Kelvin Carrasquillo Carrion, Jason B. Giles, Abiel Roche Lima, Kevin Yee, Xiaoxiao Sun, Larisa H. Cavallari, Minoli A. Perera, Jorge Duconge, Jason H. Karnes
Publikováno v:
Clinical pharmacology and therapeutics.
Accuracy of warfarin dose prediction algorithms may be improved by including data from diverse populations in genetic studies of dose variability. Here, we surveyed single nucleotide polymorphisms in vitamin K-related genes for association with warfa
Autor:
Vineet Nair, Tae Hwi Schwantes-An, Haiyang Tang, Rebecca Vanderpool, Roham T. Zamanian, Jason B. Giles, Franz Rischard, Jason X.-J. Yuan, Michael W. Pauciulo, Rick A. Kittles, Abhishek Chaturvedi, Balaji Natarajan, Vinicio A. de Jesus Perez, Ankit A. Desai, Katie A. Lutz, Ken Batai, William C. Nichols, Jason H. Karnes, Joe G.N. Garcia, Jeffrey Yu, Anna W. Coleman, Raymond L. Benza, Andrew J. Sweatt, Hemant K. Tiwari, Howard W. Wiener, Heidi E. Steiner, Maryam Hosseini, Amit Arora, Jeremy Feldman
Publikováno v:
American journal of respiratory and critical care medicine, vol 201, iss 11
Rationale: Limited information is available on racial/ethnic differences in pulmonary arterial hypertension (PAH).Objectives: Determine effects of race/ethnicity and ancestry on mortality and disease outcomes in diverse patients with PAH.Methods: Pat
Autor:
Jason H. Karnes, Jerome Rollin, Jason B. Giles, Kiana L. Martinez, Heidi E. Steiner, Christian M. Shaffer, Yukihide Momozawa, Chihiro Inai, Andrei Bombin, Mingjian Shi, Jonathan D. Mosley, Ian Stanaway, Kathleen Selleng, Thomas Thiele, Taisei Mushiroda, Claire Pouplard, Nancy M. Heddle, Michiaki Kubo, Elizabeth J. Phillips, Theodore E. Warkentin, Yves Gruel, Andreas Greinacher, Dan M. Roden
Publikováno v:
Blood. 140(3)
Heparin-induced thrombocytopenia (HIT) is an unpredictable, potentially catastrophic adverse effect resulting from an immune response to platelet factor 4 (PF4)/heparin complexes. We performed a genome-wide association study (GWAS) with positive func
Autor:
Dorothy Quinn, Hayley Knight Patterson, Terri L. Warholak, David E. Nix, Chloe Grace, Patrick Campbell, Cheryl D. Cropp, Marti Larriva, Srujitha Marupuru, Heidi E. Steiner, Walter T. Klimecki, Jason H. Karnes
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 6, Pp 2532-2543 (2021)
Clinical and Translational Science, Vol 14, Iss 6, Pp 2532-2543 (2021)
Personal genomic educational testing (PGET) has been suggested as a strategy to improve student learning for pharmacogenomics (PGx), but no randomized studies have evaluated PGET’s educational benefit. We investigated the effect of PGET on student