Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Heidi E Hamm"'
Autor:
Ryan P. Ceddia, Zack Zurawski, Analisa Thompson Gray, Feyisayo Adegboye, Ainsley McDonald-Boyer, Fubiao Shi, Dianxin Liu, Jose Maldonado, Jiesi Feng, Yulong Li, Simon Alford, Julio E. Ayala, Owen P. McGuinness, Sheila Collins, Heidi E. Hamm
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Negative regulation of exocytosis from secretory cells is accomplished through inhibitory signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms: decreased calcium entry and direct interaction of Gβγ with soluble N-ethylmaleimide–sen
Externí odkaz:
https://doaj.org/article/a5ee21a0d0b84d4e9b842e9bacb8ba19
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The nucleus accumbens (NAc) guides reward-related motivated behavior implicated in pathological behavioral states, including addiction and depression. These behaviors depend on the precise neuromodulatory actions of Gi/o-coupled G-protein-coupled rec
Externí odkaz:
https://doaj.org/article/e89aa25bf4924d6aaa513aa36223badc
Autor:
Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Paolo Bisegna, Daniele Andreucci, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2023)
Retinal rods evolved to be able to detect single photons. Despite their exquisite sensitivity, rods operate over many log units of light intensity. Several processes inside photoreceptor cells make this incredible light adaptation possible. Here, we
Externí odkaz:
https://doaj.org/article/5e6823c4d31b43a888fb036601b0ea7d
Autor:
Polina Geva, Giovanni Caruso, Colin Klaus, Heidi E. Hamm, Vsevolod V. Gurevich, Emmanuele DiBenedetto, Clint L. Makino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Accurate photon counting requires that rods generate highly amplified, reproducible single photon responses (SPRs). The SPR is generated within the rod outer segment (ROS), a multilayered structure built from membranous disks that house rhodopsin. Ph
Externí odkaz:
https://doaj.org/article/fe3df3c0174a40f28486ece3f8b606c3
Autor:
Colin Klaus, Giovanni Caruso, Vsevolod V. Gurevich, Heidi E. Hamm, Clint L. Makino, Emmanuele DiBenedetto
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
In daylight, cone photoreceptors in the retina are responsible for the bulk of visual perception, yet compared to rods, far less is known quantitatively about their biochemistry. This is partly because it is hard to isolate and purify cone proteins.
Externí odkaz:
https://doaj.org/article/a17d3d185c0b4bea99d37b1564483c72
Autor:
Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Publikováno v:
Platelets, Vol 30, Iss 1, Pp 126-135 (2019)
Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused
Externí odkaz:
https://doaj.org/article/6960b5c705204591a63ac3d50fe5f52c
Autor:
Giovanni Caruso, Colin J Klaus, Heidi E Hamm, Vsevolod V Gurevich, Clint L Makino, Emmanuele DiBenedetto
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0240527 (2020)
Retinal rods function as accurate photon counters to provide for vision under very dim light. To do so, rods must generate highly amplified, reproducible responses to single photons, yet outer segment architecture and randomness in the location of rh
Externí odkaz:
https://doaj.org/article/42242aa57dab4417a79264ac9ffdcd96
Autor:
Alyssa D. Lokits, Julia Koehler Leman, Kristina E. Kitko, Nathan S. Alexander, Heidi E. Hamm, Jens Meiler
Publikováno v:
AIMS Biophysics, Vol 2, Iss 4, Pp 630-648 (2015)
Cell signaling is a fundamental process for all living organisms. G protein-coupled receptors (GPCRs) are a large and diverse group of transmembrane receptors which convert extracellular signals into intracellular responses primarily via coupling to
Externí odkaz:
https://doaj.org/article/e9d9688d99ea48a5a3a032bc8232b8db
Autor:
Peter Schmidt, Brian J. Bender, Anette Kaiser, Khushboo Gulati, Holger A. Scheidt, Heidi E. Hamm, Jens Meiler, Annette G. Beck-Sickinger, Daniel Huster
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2018)
Prerequisite for structural studies on G protein-coupled receptors is the preparation of highly concentrated, stable, and biologically active receptor samples in milligram amounts of protein. Here, we present an improved protocol for Escherichia coli
Externí odkaz:
https://doaj.org/article/42d6f94ad3484c93916a544075ea711c
While the ability of G protein βγ subunits (Gβγ) to bind to and functionally inhibit the neuronal SNARE proteins Stx1A, SNAP25, and synaptobrevin in the presence of the calcium sensor synaptotagmin I is well documented, these three SNARE proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9690f0f44ec6eb354b3aeea89b0054ec
https://doi.org/10.1101/2022.05.30.494040
https://doi.org/10.1101/2022.05.30.494040
