Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Heidi Baum"'
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175653 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0173580.].
Externí odkaz:
https://doaj.org/article/0ac21232914248498cf20003ab58201b
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173580 (2017)
Plant-pathogenic Xanthomonas bacteria inject transcription activator-like effector proteins (TALEs) into host cells to specifically induce transcription of plant genes and enhance susceptibility. Although the DNA-binding mode is well-understood it is
Externí odkaz:
https://doaj.org/article/c52a30a4494348ab97c8492812e7ca2c
Autor:
Heidi Baum, Vasundhara Kain, Maureen Kachman, Kevin A. Ingle, Ganesh V. Halade, Martin E. Young, Gobinath Shanmugam, Namakkal S. Rajasekaran
Maintaining a balance of ω-6 and ω-3 fatty acids is essential for cardiac health. Current ω-6 and ω-3 fatty acids in the American diet have shifted from the ideal ratio of 2:1 to almost 20:1; while there is a body of evidence that suggests the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbaa455be1c312d73eee0ae187388a8
https://europepmc.org/articles/PMC5867649/
https://europepmc.org/articles/PMC5867649/
Autor:
Ron Sarver, Christopher Whitehead, Heidi Baum, James Hicks, Richard Gowan, Brian Sanchez, Xiao Kang Lu, Susan E. Bove, Joseph A. Cornicelli, Howard Miller, Sandra Lightle, Aurash B Shahripour, Katherine Welch, Craig Banotai, Jayvardhan Pandit, Mark S. Plummer, Timothy Braden, David Beidler, Adam Ogden, Skalitzky Donald James, Annise Paige Goodman, Howard Roark, Nalini Sadagopan, Charles J. Stankovic, Cindy Spessard, Xi Qiang Shen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3438-3442
We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of PDE4 inhibitors, while simultaneously minimizing PDE4 activity. These newly designed PDE2 inhibitors bind to the PDE2 enzyme in a cGMP-like mode in co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128c0eb423facb1ebd01be1c3f41f3b1
https://doi.org/10.1016/j.bmcl.2013.03.072
https://doi.org/10.1016/j.bmcl.2013.03.072
Autor:
Skalitzky Donald James, Craig Banotai, Jayvardhan Pandit, Adam Ogden, James Hicks, Annise Paige Goodman, Xiao Kang Lu, Howard Miller, Howard Roark, Susan E. Bove, Sandra Lightle, Aurash B Shahripour, Timothy Braden, Mark S. Plummer, Katherine Welch, Charles J. Stankovic, Ron Sarver, Joseph A. Cornicelli, Christopher Whitehead, Brian Sanchez, Nalini Sadagopan, Heidi Baum, Richard Gowan, David Beidler, Xi Qiang Shen, Cindy Spessard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3443-3447
Selective phosphodiesterase 2 (PDE2) inhibitors are shown to have efficacy in a rat model of osteoarthritis (OA) pain. We identified potent, selective PDE2 inhibitors by optimizing residual PDE2 activity in a series of phosphodiesterase 4 (PDE4) inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a8df19422ac729711863e191ea116e
https://doi.org/10.1016/j.bmcl.2013.03.082
https://doi.org/10.1016/j.bmcl.2013.03.082
Autor:
Xinmin Gan, Laurence Philippe, Brian Sanchez, Karen M. Yates, Ziqiang Wang, Arun K. Agrawal, Pil H. Lee, Cho Ming Loi, Zhen Lou, Haile Tecle, Jo Ann Dumin, Sheila Guppy, Frank Riley, Joan K. Brieland, Christopher James Deur, Sally Przybranowski, Brian Samas, Amy Mae Bunker, Mark Morris, Michael William Wilson, John Richard Booth, Joseph A. Cornicelli, Susan E. Bove, Cleo J. C. Connolly, Gregg Kamilar, Kenneth S. Kilgore, Barry C. Finzel, Heidi Baum, Kathryn A. Welch
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:4599-4603
It has been hypothesized that peripherally restricted NMDA receptor antagonists may be effective analgesics for osteoarthritis pain. A class of novel quinoxalinedione atropisomers, first discovered for an NMDA receptor antagonist program for the trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf8a8aa89569f777c79f4224db99ed
https://doi.org/10.1016/j.bmcl.2007.05.083
https://doi.org/10.1016/j.bmcl.2007.05.083
Autor:
Rene Geissler, Nancy Funk, Jan van Lunzen, Jan Chemnitz, Martina Behrens, Sven-Erik Behrens, Ilona Hauber, Heidi Baum, Ivonne Renner, Helga Hofmann-Sieber, Annekatrin Richter, Jens Boch, Joachim Hauber
Publikováno v:
Virology. 486
The major obstacle to cure infections with human immunodeficiency virus (HIV-1) is integrated proviral genomes, which are not eliminated by antiretroviral therapies (ART). Treatment approaches with latency-reversing agents (LRAs) aim at inducing prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b31461908abb3ae035d2bfb9e1b0fc9
https://pubmed.ncbi.nlm.nih.gov/26474371
https://pubmed.ncbi.nlm.nih.gov/26474371
Autor:
Thomas M. Amrein, Peter Frey, Roberto Meier, Heidi Baumann, Miriam Tanner, Klaus F. Gassenmeier
Publikováno v:
CHIMIA, Vol 68, Iss 10 (2014)
Prenyl ethyl ether (PEE) was previously described as the cause for a solvent-like off-note in ground hazelnuts, but its origin remained unclear. Investigations were carried out by analytical groups of Coop and Givaudan over four years to elucidate th
Externí odkaz:
https://doaj.org/article/709677423b42479b987187d12785daeb