Výsledky vyhledávání - "Heidi, Trusheim"

Akademický článek

Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines

Autor: Heidi Peck, Karen L. Laurie, Steve Rockman, Vivian Leung, Hilda Lau, Sally Soppe, Cleve Rynehart, Chantal Baas, Heidi Trusheim, Ian G. Barr

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)

Abstract Influenza vaccines are utilised to combat seasonal and pandemic influenza. The key to influenza vaccination currently is the availability of candidate vaccine viruses (CVVs). Ideally, CVVs reflect the antigenic characteristics of the circula

Externí odkaz: https://doaj.org/article/b461dbcec784444e92483c2eea786e20

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Comparison of suspension MDCK cells, adherent MDCK cells, and LLC‐MK2 cells for selective isolation of influenza viruses to be used as vaccine seeds

Autor: Bernhard Roth, Takato Odagiri, Norio Yamamoto, Masato Tashiro, Heidi Trusheim, Teruko Ogane, Katsumi Mizuta, Hitoshi Takahashi, Asumi Hirata-Saito, Yuichi Harada

Publikováno v: Influenza and Other Respiratory Viruses

Background: Cell-based influenza vaccines can solve the problem of the frequent occurrence of egg adaptation-associated antigenic changes observed in egg-based vaccines Seed viruses for cell-based vaccines can be prepared from clinical specimens by c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95aa436e6410933141b1ea641163c69
https://doi.org/10.1111/irv.12694

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Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus

Autor: Asumi Hirata-Saito, Kazuya Nakamura, Nami Konomi, Itsuki Hamamoto, Hideki Asanuma, Takato Odagiri, Norio Yamamoto, Yuichi Harada, Katsumi Mizuta, Roth Bernhard, Hitoshi Takahashi, Yasushi Konomi, Teruko Ogane, Masato Tashiro, Heidi Trusheim

Publikováno v: Vaccine. 37:6526-6534

Suspension Madin-Darby canine kidney (MDCK) cells (MDCK-N), adherent MDCK cells (MDCK-C), and adherent rhesus monkey kidney LLC-MK2 cells (LLC-MK2D) were systematically evaluated for the preparation of influenza vaccine seed viruses for humans on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359a5019c29efa8854df85d8a4ebb2b8
https://doi.org/10.1016/j.vaccine.2019.08.064

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Cell culture-derived influenza vaccines in the severe 2017–2018 epidemic season: a step towards improved influenza vaccine effectiveness

Autor: John W. McCauley, Takato Odagiri, Ian G. Barr, Jacqueline M. Katz, David E. Wentworth, Theodore Tsai, Ruben O. Donis, Heidi Trusheim

Publikováno v: npj Vaccines, Vol 3, Iss 1, Pp 1-5 (2018)
NPJ Vaccines

The 2017–2018 seasonal influenza epidemics were severe in the US and Australia where the A(H3N2) subtype viruses predominated. Although circulating A(H3N2) viruses did not differ antigenically from that recommended by the WHO for vaccine production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe5207092edb9fc49a26cad82364211
https://doi.org/10.1038/s41541-018-0079-z

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Current challenges in implementing cell-derived influenza vaccines: Implications for production and regulation, July 2007, NIBSC, Potters Bar, UK

Publikováno v: Vaccine. 27:2907-2913

A meeting was held at NIBSC, UK in July 2007 to discuss the implications of progress in the use of cell culture systems for the manufacture of vaccines against influenza. Issues discussed included the effect of using eggs and different cell types in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28db1556cdfef76b9e1544f53f60da62
https://doi.org/10.1016/j.vaccine.2009.02.064

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A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding

Autor: Boran Altincicek, Sandip M. Kanse, Aya Shibamiya, Michael Niepmann, Klaus T. Preissner, Heidi Trusheim, Dietmar Linder, Eleni Tzima

Publikováno v: Biochemical Journal. 394:687-692

FSAP (Factor VII-activating protease) is a novel plasma-derived serine protease that regulates haemostasis as well as vascular cell proliferation. FSAP undergoes autoactivation in the presence of polyanionic macromolecules such as heparin and RNA. Co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b73bf3d08d530d8d9bb098a19fea3d05
https://doi.org/10.1042/bj20051563

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Integrative Mitogenic Role of Protein Kinase B/Akt in β-Cells

Autor: Katja Trümper, Andrea Trümper, Rudolf Arnold, Heidi Trusheim, Dieter Hörsch, B. Göke

Publikováno v: Annals of the New York Academy of Sciences. 921:242-250

Protein kinase B/Akt (PKB/Akt) is activated by phosphatidylinositol 3-kinase (PI 3-K) and is a central mediator of cellular proliferation and protection against apoptosis. Insulin, insulin-like growth factor (IGF-1), and glucagon-like peptide-1 (GLP-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7a4259da15a1eb8518e2f7be2fdb4dd
https://doi.org/10.1111/j.1749-6632.2000.tb06972.x

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Altered Signaling and Cell Cycle Regulation in Embryonal Stem Cells with a Disruption of the Gene for Phosphoinositide 3-Kinase Regulatory Subunit p85α

Autor: Lewis C. Cantley, Heidi Trusheim, David A. Fruman, Dieter Hörsch, Kohjiro Ueki, Katja Trümper, Daniel Hallmann, C. Ronald Kahn

Publikováno v: Journal of Biological Chemistry. 278:5099-5108

The p85alpha regulatory subunit of class I(A) phosphoinositide 3-kinases (PI3K) is derived from the Pik3r1 gene, which also yields alternatively spliced variants p50alpha and p55alpha. It has been proposed that excess monomeric p85 competes with func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3828c280b0145e5baa108a377868a13d
https://doi.org/10.1074/jbc.m208451200

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DUG is a novel homologue of translation initiation factor 4G that binds eIF4A

Autor: Anja Knolle, Ruaidhrí J. Carmody, Alexandra Göke, Burkhard Göke, Rüdiger Göke, Youhai H. Chen, Harald Schmidt, Andreas Wilmen, Heidi Trusheim

Publikováno v: Biochemical and Biophysical Research Communications. 297:78-82

To elucidate the molecular mechanisms of cell death, we have cloned a new gene, designated death-upregulated gene (DUG), from rat insulinoma cells. DUG is constitutively expressed at very low levels in normal cells but is dramatically upregulated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f352185c7c79cb5d77271c2df695af2
https://doi.org/10.1016/s0006-291x(02)02129-0

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Gene Expression of the Human Glucagon-Like Peptide-1 Receptor Is Regulated by Sp1 and Sp31

Autor: Brigitte Lankat-Buttgereit, Inka Wildhage, Heidi Trusheim, Burkhard Göke

Publikováno v: Endocrinology. 140:624-631

The human glucagon-like peptide-1 (GLP-1) receptor mediates the insulinotropic effects of the incretin hormone GLP-1. It is expressed in a cell- and tissue-specific manner. Recently, we cloned the 5'-region of the GLP-1 receptor gene and found that t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e052f95a4e9254dff4365469f3e22468
https://doi.org/10.1210/endo.140.2.6512

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