Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Heidi, Dvinge"'
Publikováno v:
RNA. 27:1186-1203
Human pre-mRNA splicing is primarily catalyzed by the major spliceosome, comprising five small nuclear ribonucleoprotein complexes, U1, U2, U4, U5, and U6 snRNPs, each of which contains the corresponding U-rich snRNA. These snRNAs are encoded by larg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27560177e5aa5b4daaf0f8e0fd03d88
https://doi.org/10.1261/rna.078768.121
https://doi.org/10.1261/rna.078768.121
Autor:
Rachel E. Miles, Catherine Cargo, Mohammad Alinoor Rahman, Omar Abdel-Wahab, Adrian R. Krainer, Heidi Dvinge, Hana Cho, Robert K. Bradley, Todd R. Albrecht, Fabio M. R. Amaral, Ross L. Levine, Kiran Batta, Daichi Inoue, Fabrizio Simeoni, Deepti P. Wilks, Alessandro Pastore, Bo Wang, Xiao Jing Zhang, Daniel H. Wiseman, Eric J. Wagner, Stéphane de Botton, Eytan M. Stein, Tim C. P. Somervaille, Jean Baptiste Micol, Virginie Penard-Lacronique, Andrew M. Intlekofer, Stanley Chun-Wei Lee, Akihide Yoshimi, Kuan-Ting Lin
Publikováno v:
Nature
Transcription and pre-mRNA splicing are key steps in the control of gene expression and mutations in genes regulating each of these processes are common in leukaemia1,2. Despite the frequent overlap of mutations affecting epigenetic regulation and sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a760ce60e6920bd71e5318e7e646da
https://doi.org/10.1038/s41586-019-1618-0
https://doi.org/10.1038/s41586-019-1618-0
Autor:
Elias Oxman, Ildiko Kasza, Joshua A. Martin, Katherine A. Senn, Caroline M. Alexander, Heidi Dvinge
Publikováno v:
Mol Cell Biol
The GLUT (SLC2) family of membrane-associated transporters are described as glucose transporters. However, this family is divided into three classes and, though the regulated transporter activity of class I proteins is becoming better understood, cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11b286db412a12c0ddffc82899942e77
https://doi.org/10.1128/mcb.00480-20
https://doi.org/10.1128/mcb.00480-20
Autor:
Robert K. Bradley, Heidi Dvinge, Stephen R. Plymate, Peter S. Nelson, Cynthia C. Sprenger, Takuma Uo
Publikováno v:
Oncogene
The presence of intact ligand-binding domain (LBD) ensures the strict androgen-dependent regulation of androgen receptor (AR): binding of androgen induces structural reorganization of LBD resulting in release of AR from HSP90, suppression of nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d693fa24a3436334c4dad3578ef45c4b
https://doi.org/10.1038/onc.2016.313
https://doi.org/10.1038/onc.2016.313
Autor:
Heidi Dvinge, James Palacino, Robert K. Bradley, Chun-Wei Chen, Xujun Wang, Justin Taylor, Pete Smith, Alessandro Pastore, Jean-Baptiste Micol, Scott A. Armstrong, Benjamin H. Durham, Michael P. Thomas, Eunhee Kim, Camille Lobry, Silvia Buonamici, Stanley Chun-Wei Lee, Young Joon Kim, Young Rock Chung, Omar Abdel-Wahab, Akihide Yoshimi, Andrei V. Krivtsov, Hana Cho
Publikováno v:
Nature Medicine. 22:672-678
Mutations in genes encoding splicing factors (which we refer to as spliceosomal genes) are commonly found in patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). These mutations recurrently affect specific amino acid residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4794e4de1c014d3a79b3c45952b90103
https://doi.org/10.1038/nm.4097
https://doi.org/10.1038/nm.4097
Alternative splicing of pre-mRNAs plays a pivotal role during the establishment and maintenance of human cell types. Characterizing the trans-acting regulatory proteins that control alternative splicing has therefore been the focus of much research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1c8852f35edd7b3329e2c17c7d45c7
Autor:
Heidi Dvinge
Publikováno v:
FEBS letters. 592(17)
Nearly all human multiexon genes are subject to alternative splicing in one or more cell types. The splicing machinery therefore has to select between multiple splice sites in a context-dependent manner, relying on sequence features in cis- and trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b6c237ad70cb3108785dd385179290a
https://pubmed.ncbi.nlm.nih.gov/29856907
https://pubmed.ncbi.nlm.nih.gov/29856907
Autor:
Gerard A. Tarulli, Carlos Caldas, Theresa E. Hickey, Wayne D. Tilley, Dong Gui Hu, Stephen R. Plymate, Ganesh V. Raj, Luke A. Selth, Natalie K. Ryan, Adrienne R. Hanson, Stephen N. Birrell, Peter I. Mackenzie, Scott M. Dehm, Connie M. Irvine, Heidi Dvinge, Marie A. Pickering, Roslin Russell, Robert K. Bradley
Publikováno v:
Oncotarget
// Theresa E. Hickey 1, * , Connie M. Irvine 1, * , Heidi Dvinge 2, 3 , Gerard A. Tarulli 1 , Adrienne R. Hanson 1 , Natalie K. Ryan 1 , Marie A. Pickering 1 , Stephen N. Birrell 1 , Dong Gui Hu 4 , Peter I. Mackenzie 4 , Roslin Russell 5 , Carlos Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6ba8c6e83d8d8df41c6234b2f36ac66
http://europepmc.org/articles/PMC4792588
http://europepmc.org/articles/PMC4792588
Autor:
Yi-Mi Wu, Glenn C. Gaviola, Massimo Loda, Scott A. Tomlins, Raquel Perez-Lopez, Bruce Montgomery, Himisha Beltran, Jeremy C. Durack, Mary-Ellen Taplin, Michael J. Morris, David Smith, Charles L. Sawyers, Arul M. Chinnaiyan, Penny Flohr, Anuradha Gopalan, Howard I. Scher, Christine Brennan, Carrie Sougnez, Scott T. Tagawa, Roberta Ferraldeschi, Rohit Mehra, Stephen P. Balk, Manaswi Gupta, Eliezer M. Van Allen, Philip W. Kantoff, Rosina T. Lis, Evan Y. Yu, Jianjiong Gao, Kenneth J. Pienta, Xuhong Cao, Joaquin Mateo, Johann S. de Bono, Maha Hussain, Olivier Elemento, Stephen B. Solomon, Zafeiris Zafeiriou, Robert J. Lonigro, Wassim Abida, Hyojeong Mulcahy, Jake Vinson, Gerhardt Attard, Andrea Sboner, Nina Tunariu, Javed Siddiqui, Yu Chen, Michaela Bowden, Colin C. Pritchard, Lakshmi P. Kunju, Susana Miranda, Lawrence D. True, Felix Y. Feng, Heather H. Cheng, Kathleen A. Cooney, Peter S. Nelson, Francesca Demichelis, Pankaj Vats, Dan R. Robinson, Brian D. Robinson, Marc H. Schiffman, Mark A. Rubin, Kenneth Eng, Juan Miguel Mosquera, Stephen R. Plymate, Elahe A. Mostaghel, Robert K. Bradley, Alexandros Sigaras, Elisabeth I. Heath, Nikolaus Schultz, Heidi Dvinge, Victor E. Reuter, Dana E. Rathkopf, Levi A. Garraway, David M. Nanus
Publikováno v:
Cell. 161:1215-1228
SummaryToward development of a precision medicine framework for metastatic, castration-resistant prostate cancer (mCRPC), we established a multi-institutional clinical sequencing infrastructure to conduct prospective whole-exome and transcriptome seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295f6e5ec4b1b918591eefcf24e8e7ac
https://doi.org/10.1016/j.cell.2015.05.001
https://doi.org/10.1016/j.cell.2015.05.001
Autor:
Carlos Caldas, Andrew R. Green, Elena Provenzano, Suet-Feung Chin, Eric A. Miska, Yongjun Zhao, Heidi Dvinge, Anna Git, Ian O. Ellis, Andrea Sottoriva, Gulisa Turashvili, Martin Hirst, Christina Curtis, Stefan Gräf, Javier Armisen, Samuel Aparicio, Mali Salmon-Divon
Publikováno v:
Nature. 497:378-382
MicroRNAs (miRNAs) show differential expression across breast cancer subtypes, and have both oncogenic and tumour-suppressive roles. Here we report the miRNA expression profiles of 1,302 breast tumours with matching detailed clinical annotation, long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ae944c664f77b91cff1508fea6b128
https://doi.org/10.1038/nature12108
https://doi.org/10.1038/nature12108