Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Heidelinde Fiegl"'
Autor:
Simon Schnaiter, Esther Schamschula, Juliane Laschtowiczka, Heidelinde Fiegl, Johannes Zschocke, Alain Zeimet, Katharina Wimmer, Daniel Reimer
Publikováno v:
Cancers, Vol 16, Iss 11, p 2129 (2024)
Background: Homologous recombination deficiency (HRD) has evolved into a major diagnostic marker in high-grade ovarian cancer (HGOC), predicting the response to poly (adenosine diphosphate-ribose) polymerase inhibitors (PARPi) and also platinum-based
Externí odkaz:
https://doaj.org/article/8fb44c7ed9cf47859f312b7396c8ac66
Autor:
Gerlinde Karbon, Manuel D. Haschka, Hubert Hackl, Claudia Soratroi, Lourdes Rocamora-Reverte, Walther Parson, Heidelinde Fiegl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Abstract Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mi
Externí odkaz:
https://doaj.org/article/be72c07d709a45b1826c65c6dd5e8661
Autor:
Gudrun Ratzinger, Simone Mitteregger, Barbara Wolf, Regina Berger, Bernhard Zelger, Georg Weinlich, Peter Fritsch, Georg Goebel, Heidelinde Fiegl
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 7, Pp 11984-11995 (2014)
In this retrospective pilot study, the DNA-methylation status of genes that have been demonstrated to be involved in melanoma carcinogenesis was analyzed in order to identify novel biomarkers for the risk assessment of melanoma patients. We analyzed
Externí odkaz:
https://doaj.org/article/7248b668c10b410094e64beef5f1e742
Autor:
Verena Wieser, Susanne Sprung, Irina Tsibulak, Johannes Haybaeck, Hubert Hackl, Heidelinde Fiegl, Christian Marth, Alain Gustave Zeimet
Publikováno v:
Cancers, Vol 11, Iss 6, p 791 (2019)
Ovarian cancer (OC) is a gynaecological malignancy with poor clinical outcome and limited treatment options. The receptor activator of nuclear factor-κB (RANK) pathway, activated by RANK ligand (RANKL), critically controls bone metabolism, tumourige
Externí odkaz:
https://doaj.org/article/d6e42c7ca75a46ff88e50a0255e7f35d
Autor:
Catherine Dold, Carles Rodriguez Urbiola, Guido Wollmann, Lisa Egerer, Alexander Muik, Lydia Bellmann, Heidelinde Fiegl, Christian Marth, Janine Kimpel, Dorothee von Laer
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
Previously, we described an oncolytic vesicular stomatitis virus variant pseudotyped with the nonneurotropic glycoprotein of the lymphocytic choriomeningitis virus, VSV-GP, which was highly effective in glioblastoma. Here, we tested its potency for t
Externí odkaz:
https://doaj.org/article/0a9e213944ea46c5ae1bc62dac155728
Autor:
Mariana E De Araujo, Gertraud Erhart, Katharina Buck, Elisabeth Müller-Holzner, Michael Hubalek, Heidelinde Fiegl, Daniele Campa, Federico Canzian, Ursula Eilber, Jenny Chang-Claude, Stefan Coassin, Margot Haun, Lyudmyla Kedenko, Bernhard Paulweber, Roland Reitsamer, Irmgard Himmel, Dieter Flesch-Janys, Claudia Lamina, Florian Kronenberg, Lukas A Huber, Anita Kloss-Brandstätter
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53768 (2013)
BACKGROUND: The late endosomal LAMTOR complex serves as a convergence point for both the RAF/MEK/ERK and the PI3K/AKT/mTOR pathways. Interestingly, both of these signalling cascades play a significant role in the aetiology of breast cancer. Our aim w
Externí odkaz:
https://doaj.org/article/e772d3dec6e045798589b1addc854ea0
Autor:
Verena Wieser, Irina Tsibulak, Daniel Uwe Reimer, Alain Gustave Zeimet, Heidelinde Fiegl, Hubert Hackl, Christian Marth
Publikováno v:
Gynecologic Oncology. 170:290-299
Autor:
Max Holzknecht, Lena Guerrero‐Navarro, Michele Petit, Eva Albertini, Elisabeth Damisch, Anna Simonini, Fernando Schmitt, Walther Parson, Heidelinde Fiegl, Alexander Weiss, Pidder Jansen‐Duerr
Publikováno v:
FEBS Letters. 596:2781-2794
The mitochondrial enzyme fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) was identified to be upregulated in breast cancer tissues. Here, we show that FAHD1 is indispensable for the survival of BT-20 cells, representing the basal br
Autor:
Heidelinde Fiegl, Alexandar Tzankov, Christian Ploner, Stephan Geley, Waldemar Chmelewskij, Anna Frenzel, Verena Labi, Andreas Villunger
Publikováno v:
Blood. 115(5)
Oncogenic c-Myc is known to balance excessive proliferation by apoptosis that can be triggered by p53-dependent and p53-independent signaling networks. Here, we provide evidence that the BH3-only proapoptotic Bcl-2 family members Bcl-2 modifying fact