Výsledky vyhledávání - "Heide Christine Patterson"

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

Autor: Stephanie K. Dougan, Hidde L. Ploegh, Nai-Jia Huang, Angelina M. Bilate, Hojun Li, Djenet Bousbaine, Harvey F. Lodish, Novalia Pishesha, Takeshi Maruyama, Marsha C. Wibowo, Heide Christine Patterson, Zeyang Li, Rhogerry Deshycka

Publikováno v: Proceedings of the National Academy of Sciences. 114:3157-3162

Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that act prophylactically or the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd9835f9ba614785364672d28ca5cf7
https://doi.org/10.1073/pnas.1701746114

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Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas lpr mouse

Autor: Heide Christine Patterson, George C. Tsokos, Katalin Kis-Toth, Duc Hung Pham, To-Ha Thai, Denise A. Kaminski

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 110(50), 20194-20199. NATL ACAD SCIENCES

MicroRNA-155 (miR-155) regulates antibody responses and subsequent B-cell effector functions to exogenous antigens. However, the role of miR-155 in systemic autoimmunity is not known. Using the death receptor deficient (Fas(lpr)) lupus-prone mouse, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0ceeb995f1f0a6b9a684fa573b436c
https://doi.org/10.1073/pnas.1317632110

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Correction for Patterson et al., A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 113(14)

Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) govern cellular homeostasis by inducing signaling. H2O2 modulates the activity of phosphatases and many other signaling molecules through oxidation of critical cysteine residues, which le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f569b1ccac5159e8d193a428943dee19
https://pubmed.ncbi.nlm.nih.gov/26438848

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Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number

Autor: Daniel E. Bauer, Jennifer C. Eng, Heide Christine Patterson, Vijay G. Sankaran, Ryan A. Metcalf, Yasodha Natkunam, Ewa Sicinska, Piotr Sicinski, Eric S. Lander, Harvey F. Lodish, Jian Xu, Leif S. Ludwig, Stuart H. Orkin

Publikováno v: Genes and Development

Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d80cbfac30bca05f52e789e0933d27
https://doi.org/10.1101/gad.197020.112

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Cytoplasmic Igα Serine/Threonines Fine-Tune Igα Tyrosine Phosphorylation and Limit Bone Marrow Plasma Cell Formation

Autor: Donghai Wang, Manfred Kraus, Jane Seagal, Joel M. Henderson, To-Ha Thai, Aliakbar Shahsafaei, Klaus Rajewsky, Kevin L. Otipoby, Heide Christine Patterson

Publikováno v: The Journal of Immunology. 187:2853-2858

Igα serine 191 and 197 and threonine 203, which are located in proximity of the Igα ITAM, dampen Igα ITAM tyrosine phosphorylation. In this study, we show that mice with targeted mutations of Igα S191, 197, and T203 displayed elevated serum IgG2c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd7c9bed4f9f6d4f4d0555cd9539207
https://doi.org/10.4049/jimmunol.1101143

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A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates hydrogen peroxide signaling

Publikováno v: Proceedings of the National Academy of Sciences. 112

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c989a88c9e8fafb49a5bb5fbcf799607
https://doi.org/10.1073/pnas.1517932112

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The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Igα Cytoplasmic Domain

Autor: Manfred Kraus, Hidde L. Ploegh, You-Me Kim, Heide Christine Patterson, Klaus Rajewsky

Publikováno v: Immunity. 25(1):55-65

In addition to the tyrosines of the Igalpha and beta immunoreceptor tyrosine-based activation motifs (ITAMs), the evolutionarily conserved Igalpha non-ITAM tyrosine 204 becomes phosphorylated upon antigen recognition by the B cell receptor (BCR). Her

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29751fab167f9aacddd9cdbe111e02e1

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Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation

Autor: Maki Murata-Hori, Dirk Görlich, Sandra Martinez-Morilla, Katharina Paulsen, Jiahai Shi, Karly Burke, Amalia Avila-Figueroa, Harvey F. Lodish, Srividhya Venkatesan, Shilpa M. Hattangadi, Junxia Wang, Heide Christine Patterson

Publikováno v: Blood

Global nuclear condensation, culminating in enucleation during terminal erythropoiesis, is poorly understood. Proteomic examination of extruded erythroid nuclei from fetal liver revealed a striking depletion of most nuclear proteins, suggesting that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e28a50d3de6d08ce602921d6a257b47
https://europepmc.org/articles/PMC4168348/

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Protein kinase inhibitors in the treatment of inflammatory and autoimmune diseases

Autor: Robert J. B. Nibbs, Stefan Siebert, Heide Christine Patterson, Iain B. McInnes

Summary Protein kinases mediate protein phosphorylation, which is a fundamental component of cell signalling, with crucial roles in most signal transduction cascades: from controlling cell growth and proliferation to the initiation and regulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e66b20c954cb80279707b32b9e189d1
https://europepmc.org/articles/PMC3958149/

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MicroRNAs are required for the feature maintenance and differentiation of brown adipocytes

Autor: Jean-Paul Kovalik, Vera J. Goh, Hyejin Kim, Lei Sun, Ryan Alexander, Mirko Trajkovski, Harvey F. Lodish, Dan Xu, David L. Silver, Long N. Nguyen, Minxia Gu, Xiaoran Chai, Sujoy Ghosh, Kinyui Alice Lo, Heide Christine Patterson, Cher X. Huang, Hyunjii Cho

Publikováno v: Diabetes, Vol. 63, No 12 (2014) pp. 4045-4056
Diabetes

Brown adipose tissue (BAT) is specialized to burn lipids for heat generation as a natural defense against cold and obesity. Previous studies established microRNAs (miRNAs) as essential regulators of brown adipocyte differentiation, but whether miRNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2483135e7e9ea0cd4e2da763147153
https://archive-ouverte.unige.ch/unige:156964

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