Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hei-Man Wu"'
Autor:
Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin stud
Externí odkaz:
https://doaj.org/article/2799ba1feac14143b49c5a113c6f2e18
Autor:
Shing Wan Choi, Judit García-González, Yunfeng Ruan, Hei Man Wu, Christian Porras, Jessica Johnson, Bipolar Disorder Working group of the Psychiatric Genomics Consortium, Clive J Hoggart, Paul F O'Reilly
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010624 (2023)
Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and applications. While numerous statistical and machine learning methods have
Externí odkaz:
https://doaj.org/article/fa6cb295ad9744b995c23552d54898cf
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Here we report how four major forms of Alzheimer’s disease (AD) genetic risk—APOE-ε4, APOE-ε2, polygenic risk and familial risk—are associated with 273 traits in ~500,000 individuals in the UK Biobank. The traits cover blood biochemi
Externí odkaz:
https://doaj.org/article/9edb8d581d9146db8c30c535ab5c196b
Autor:
Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/b8f7864507614fd0b460beee417de315
The use of siblings to infer the factors influencing complex traits has been a cornerstone of quantitative genetics. Here we utilise siblings for a novel application: the identification of genetic architecture, specifically that in individuals with e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6b3d7bb571f420dc6b4c60851b3aa7
https://doi.org/10.1101/2023.02.19.529159
https://doi.org/10.1101/2023.02.19.529159
Autor:
Nora I. Strom, Christie L. Burton, Conrad Iyegbe, Talisa Silzer, Lilit Antonyan, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Danielle Cath, Jennifer Crosbie, David Mataix-Cols, Dorret I. Boomsma, Manuel Mattheisen, Sandra M. Meier, Dirk J.A. Smit, Paul D. Arnold
While 1-2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (∼15-40%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To characterize the genetic underpinnings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9c54b882a94b86076c15a3bea67f55d
https://doi.org/10.1101/2022.11.30.22282898
https://doi.org/10.1101/2022.11.30.22282898
Autor:
Nora I. Strom, Dirk J.A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9851d128aa0794943f8f498b2bd1fda2
https://doi.org/10.1101/2022.06.19.22276077
https://doi.org/10.1101/2022.06.19.22276077
Autor:
Cathryn M. Lewis, Richard A. Russell, Paul F. O'Reilly, Hei Man Wu, Jessye Maxwell, Natasha Sharapova, Peter Banthorpe
Publikováno v:
Annals of Actuarial Science. 15:488-503
During the past decade, genetics research has allowed scientists and clinicians to explore the human genome in detail and reveal many thousands of common genetic variants associated with disease. Genetic risk scores, known as polygenic risk scores (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a4c8384f11b099f0110b48e1be408b
https://doi.org/10.1017/s1748499520000226
https://doi.org/10.1017/s1748499520000226
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Here we report how four major forms of Alzheimer’s disease (AD) genetic risk—APOE-ε4, APOE-ε2, polygenic risk and familial risk—are associated with 273 traits in ~500,000 individuals in the UK Biobank. The traits cover blood biochemistry and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68a5928a3cc08dd71aa17191fe2a6b9
https://doi.org/10.1038/s41398-021-01518-0
https://doi.org/10.1038/s41398-021-01518-0
Autor:
Jessica S. Johnson, Paul F. O'Reilly, Judit García-González, Yunfeng Ruan, Shing Wan Choi, Hei Man Wu
Publikováno v:
European Neuropsychopharmacology. 51:e155-e156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5077e97bb118b40c9456a3931b88ad1
https://doi.org/10.1016/j.euroneuro.2021.08.108
https://doi.org/10.1016/j.euroneuro.2021.08.108