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Akademický článek

The role of TGFBI in mesothelioma and breast cancer: association with tumor suppression

Autor: Li Bingyan, Wen Gengyun, Zhao Yongliang, Tong Jian, Hei Tom K

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 239 (2012)

Abstract Background Transforming growth factor β induced (TGFBI) product, an extracellular matrix (ECM) protein, has been implicated as a putative tumor suppressor in recent studies. Our previous findings revealed that expression of TGFBI gene is do

Externí odkaz: https://doaj.org/article/b62fc3cab0f54f628aaabde2eb7b3548

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Akademický článek

Regulation of early signaling and gene expression in the α-particle and bystander response of IMR-90 human fibroblasts

Autor: Hei Tom K, Ivanov Vladimir N, Ming Lihua, Ghandhi Shanaz A, Amundson Sally A

Publikováno v: BMC Medical Genomics, Vol 3, Iss 1, p 31 (2010)

Abstract Background The existence of a radiation bystander effect, in which non-irradiated cells respond to signals from irradiated cells, is well established. To understand early signaling and gene regulation in bystander cells, we used a bio-inform

Externí odkaz: https://doaj.org/article/48e46ad4f5dc4af3a06777e318b92c6b

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Akademický článek

Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells

Autor: Nohmi Takehiko, Chai Yunfei, Xu An, Hei Tom K

Publikováno v: Particle and Fibre Toxicology, Vol 6, Iss 1, p 3 (2009)

Abstract Background Titanium dioxide (TiO2) nanoparticles and fullerene (C60) are two attractive manufactured nanoparticles with great promise in industrial and medical applications. However, little is known about the genotoxic response of TiO2 nanop

Externí odkaz: https://doaj.org/article/4b387714d9f943a3976ccf40d3bffce0

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Akademický článek

Methylation screening of the TGFBI promoter in human lung and prostate cancer by methylation-specific PCR

Autor: Shao Genze, Shah Jinesh N, Hei Tom K, Zhao Yongliang

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 284 (2008)

Abstract Background Hypermethylation of the TGFBI promoter has been shown to correlate with decreased expression of this gene in human tumor cell lines. In this study, we optimized a methylation-specific polymerase chain reaction (MSP) method and inv

Externí odkaz: https://doaj.org/article/c4aebea25eba4757b9f8c49808966011

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