Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hei Man Fan"'
Autor:
Kypros H. Nicolaides, Caroline Ovadia, Joanna Girling, Marcus Martineau, Catherine Williamson, Argyro Syngelaki, Paul T. Seed, Tharni Vasavan, K. Souretis, Hei Man Fan, Alice Mitchell, John C. Chambers, Jrf Walters
Publikováno v:
BJOG: An International Journal of Obstetrics & Gynaecology. 128:1635-1644
OBJECTIVE To determine the optimal total serum bile acid (TSBA) threshold and sampling time for accurate intrahepatic cholestasis of pregnancy (ICP) diagnosis. DESIGN Case-control, retrospective cohort studies. SETTING Antenatal clinics, clinical res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f9ac8ab3e8fc6a0b8941a70bd78580a
https://doi.org/10.1111/1471-0528.16669
https://doi.org/10.1111/1471-0528.16669
Autor:
Hei Man Fan, Alice L. Mitchell, Elena Bellafante, Saraid McIlvride, Laura I. Primicheru, Mirko Giorgi, Ivano Eberini, Argyro Syngelaki, Anita Lövgren-Sandblom, Peter Jones, David McCance, Nithya Sukumar, Nishanthi Periyathambi, Yonas Weldeselassie, Katharine F. Hunt, Kypros H. Nicolaides, David Andersson, Stuart Bevan, Paul T. Seed, Gavin A. Bewick, James E. Bowe, Franca Fraternali, Ponnusamy Saravanan, Hanns-Ulrich Marschall, Catherine Williamson
Serum progesterone sulfates were evaluated in the etiology of gestational diabetes mellitus (GDM). Serum progesterone sulfates were measured using ultra-performance liquid chromatography–tandem mass spectrometry in four patient cohorts: 1) the Hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e157d696956654f3b925c7fdb3198f6
https://doi.org/10.2337/figshare.18813578.v1
https://doi.org/10.2337/figshare.18813578.v1
Autor:
David R. McCance, Katharine F. Hunt, Franca Fraternali, David Andersson, James E. Bowe, Catherine Williamson, Mirko Giorgi, Stuart Bevan, Alice Mitchell, Hanns-Ulrich Marschall, Ivano Eberini, Hei Man Fan, Peter B. Jones
Publikováno v:
Diabetes. 70
Introduction: Serum progesterone sulfate (P4S) concentrations increase in pregnancy and bind receptors that influence glucose homeostasis. We hypothesized that P4S modulate glucose homeostasis in pregnancy. Methods: Serum P4S were assayed using ultra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bd129cf2e71b14080100e16efbbb70b
https://doi.org/10.2337/db21-941-p
https://doi.org/10.2337/db21-941-p
Autor:
Annika Wahlström, Catherine Williamson, Elena Bellafante, Peter R. Jones, David Shapiro, Eugene Jansen, Vanya Nikolova, Luciano Adorini, Julie A. K. McDonald, Hanns-Ulrich Marschall, Saraid McIlvride, Hei Man Fan, Julian R. Marchesi
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism
McIlvride, S, Nikolova, V, Fan, H M, McDonald, J A K, Wahlström, A, Bellafante, E, Jansen, E, Adorini, L, Shapiro, D, Jones, P, Marchesi, J R, Marschall, H U & Williamson, C 2019, ' Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes ', American Journal of Physiology-Endocrinology and Metabolism, vol. 317, no. 2, pp. E399-E410 . https://doi.org/10.1152/ajpendo.00407.2018
McIlvride, S, Nikolova, V, Fan, H M, McDonald, J A K, Wahlström, A, Bellafante, E, Jansen, E, Adorini, L, Shapiro, D, Jones, P, Marchesi, J R, Marschall, H U & Williamson, C 2019, ' Obeticholic acid ameliorates dyslipidemia but not glucose tolerance in mouse model of gestational diabetes ', American Journal of Physiology-Endocrinology and Metabolism, vol. 317, no. 2, pp. E399-E410 . https://doi.org/10.1152/ajpendo.00407.2018
Metabolism alters markedly with advancing gestation, characterized by progressive insulin resistance, dyslipidemia, and raised serum bile acids. The nuclear receptor farnesoid X receptor (FXR) has an integral role in bile acid homeostasis and modulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391e8696e80e0a8a363bb3dd556e3afc
https://doi.org/10.1152/ajpendo.00407.2018
https://doi.org/10.1152/ajpendo.00407.2018
Publikováno v:
European journal of endocrinology. 184(3)
Bile acids are lipid-solubilising molecules that also regulate metabolic processes. Farnesoid X receptor (FXR) and Takeda G-protein coupled receptor 5 (TGR5) are two bile acid receptors with key metabolic roles. FXR regulates bile acid synthesis in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ffcc17fa72a2beda0154b8fe1df909
https://pubmed.ncbi.nlm.nih.gov/33434155
https://pubmed.ncbi.nlm.nih.gov/33434155
Autor:
Peter M. Jones, Vanya Nikolova, Catherine Williamson, Elena Bellafante, Hanns-Ulrich Marschall, Anita Banerjee, Luiza Borges Manna, Saraid McIlvride, Marcus Martineau, Mavis Machirori, Jenny Chambers, Kevin Murphy, Kristina Schoonjans, Hei Man Fan
Publikováno v:
Bellafante, E, Mcilvride, S, Nikolova, V, Fan, H M, Borges Manna, L, Chambers, J, MacHirori, M, Banerjee, A, Murphy, K, Martineau, M G, Schoonjans, K, Marschall, H-U, Jones, P & Williamson, C 2020, ' Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis ', Scientific Reports .
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20460c6ca2d593d12a2101995ef0c260
https://kclpure.kcl.ac.uk/portal/en/publications/maternal-glucose-homeostasis-is-impaired-in-mouse-models-of-gestational-cholestasis(3e22c11b-198e-4314-8fae-984cc0df980e).html
https://kclpure.kcl.ac.uk/portal/en/publications/maternal-glucose-homeostasis-is-impaired-in-mouse-models-of-gestational-cholestasis(3e22c11b-198e-4314-8fae-984cc0df980e).html
Autor:
Marcus Ståhlman, Julian R.F. Walters, Louise C. D. Clarke, Anastasia Tsakmaki, Julie A. K. McDonald, Catherine Williamson, Alexandros Sklavounos, Caroline Ovadia, Benjamin H. Mullish, Julian R. Marchesi, Alvaro Perdones-Montero, Gavin A. Bewick, Georgia Papacleovoulou, Peter H. Dixon, Hei Man Fan, Hanns-Ulrich Marschall, Annika Wahlström
Publikováno v:
Ovadia, C, Perdones-Montero, A, Fan, H M, Mullish, B H, McDonald, J A K, Papacleovoulou, G, Wahlström, A, Ståhlman, M, Tsakmaki, A, Clarke, L C D, Sklavounos, A, Dixon, P H, Bewick, G A, Walters, J R F, Marschall, H-U, Marchesi, J R & Williamson, C 2020, ' Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy ', Scientific Reports, vol. 10, no. 1, 3895 . https://doi.org/10.1038/s41598-020-60821-w
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic signalling. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f472239b0a4b19b4678ace8bf1c4894
https://kclpure.kcl.ac.uk/en/publications/f39c8578-fe7d-472c-bc93-59044f397cdd
https://kclpure.kcl.ac.uk/en/publications/f39c8578-fe7d-472c-bc93-59044f397cdd
Publikováno v:
European Journal of Endocrinology; Mar2021, Vol. 184 Issue 3, pR69-R83, 15p
Autor:
Elena Bellafante, James E. Bowe, Catherine Williamson, Kate Hunt, Gavin A. Bewick, Caroline Ovadia, Hanns-Ulrich Marschall, Peter R. Jones, Alice Mitchell, David R. McCance, Marcus Martineau, Hei Man Fan
Publikováno v:
Endocrine Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::240c6f00bc85f0bf8fbea8d3a8bfb9c9
https://doi.org/10.1530/endoabs.65.p181
https://doi.org/10.1530/endoabs.65.p181
Autor:
Bellafante, Elena1, McIlvride, Saraid1, Nikolova, Vanya1, Fan, Hei Man1, Manna, Luiza Borges1, Chambers, Jenny1,2, Machirori, Mavis2, Banerjee, Anita3, Murphy, Kevin4, Martineau, Marcus5, Schoonjans, Kristina6, Marschall, Hanns-Ulrich7, Jones, Peter1, Williamson, Catherine1,8 catherine.williamson@kcl.ac.uk
Publikováno v:
Scientific Reports. 7/13/2020, Vol. 10 Issue 1, p1-10. 10p.