Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hehui Fang"'
Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Autor:
Juan Jin, Hehui Fang, Fang Yang, Wenfei Ji, Nan Guan, Zijia Sun, Yaqin Shi, Guohua Zhou, Xiaoxiang Guan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 478-488 (2018)
Triple negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that poses a clinical challenge. Thus, new therapy strategies are urgently needed. The selective WEE1 inhibitor, AZD1775, has shown strong anti-proliferative effects
Externí odkaz:
https://doaj.org/article/54d155782bd747e1bd718b167ecda06d
Publikováno v:
Cancer Science. 109:1949-1957
Tyrosine kinase Src is overexpressed and activated in various tumors, including breast cancer, and is supposed to promote cancer formation and development. Src inhibitors have been developed recently and have shown efficacy in breast cancer as a sing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c18fd92f429d1a99d1e0f464ebb8388
https://doi.org/10.1111/cas.13593
https://doi.org/10.1111/cas.13593
Combined Inhibition of ATR and WEE1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Autor:
Guohua Zhou, Xiaoxiang Guan, Wenfei Ji, Zijia Sun, Juan Jin, Hehui Fang, Yaqin Shi, Nan Guan, Fang Yang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 478-488 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Triple negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that poses a clinical challenge. Thus, new therapy strategies are urgently needed. The selective WEE1 inhibitor, AZD1775, has shown strong anti-proliferative effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d152087a55637522cf428eb9b3440d
https://doi.org/10.1016/j.neo.2018.03.003
https://doi.org/10.1016/j.neo.2018.03.003
Publikováno v:
Breast Cancer Research and Treatment. 168:287-297
Cyclin D/cyclin-dependent kinase 4/6 (CDK4/6) complex inhibitors have recently been proven effective when combined with endocrine therapy in clinical trials. However, the clinical benefit from CDK4/6 inhibitor varied from different patients. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83abd6a29c585274c7c4b0a961198fa3
https://doi.org/10.1007/s10549-017-4612-y
https://doi.org/10.1007/s10549-017-4612-y
Endothelial cells promote triple‐negative breast cancer cell metastasis via PAI‐1 and CCL5 signaling
Autor:
Lulu Cao, Qun Zhang, Wenwen Zhang, Yucai Wang, Xiaoxiang Guan, Hehui Fang, Weiwei Chen, Lin Tang, Fang Yang, Qian Sun, Jing Xu, Zijia Sun
Publikováno v:
The FASEB Journal. 32:276-288
Endothelial cells (ECs) in the tumor microenvironment have been reported to play a more active role in solid tumor growth and metastatic dissemination than simply providing the physical structure to form conduits for blood flow; however, the involvem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d24d657e3eeb1ce7c97c01fff535b50b
https://doi.org/10.1096/fj.201700237rr
https://doi.org/10.1096/fj.201700237rr
Publikováno v:
International Journal of Biological Sciences
Triple-negative breast cancer (TNBC) is a tumor subtype with aggressive behavior and poor clinical outcome for lacking effective therapies. Breast cancer stem cells (BCSCs) have been suggested to have tumor-initiating properties, but it remains uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38fab9392e9a18735cc7415b1e9a955
http://europepmc.org/articles/PMC5166497
http://europepmc.org/articles/PMC5166497
Autor:
Wenwen Zhang, Lin Tang, Wenfei Ji, Doudou Huang, Hehui Fang, Fang Yang, Xiaoxiang Guan, Weiwei Chen, Guohua Zhou, Yan Shen, Yaqin Shi, Juan Jin
Androgen receptor (AR) is emerging as a novel prognostic biomarker in triple-negative breast cancer (TNBC), but the underlying mechanisms remain unknown. As accumulating evidence has shown that long non-coding RNAs (lncRNAs) regulate important cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7569b537889396494927a4f5ea6ae5e
https://europepmc.org/articles/PMC6261952/
https://europepmc.org/articles/PMC6261952/
Autor:
Wenwen, Zhang, Jing, Xu, Hehui, Fang, Lin, Tang, Weiwei, Chen, Qian, Sun, Qun, Zhang, Fang, Yang, Zijia, Sun, Lulu, Cao, Yucai, Wang, Xiaoxiang, Guan
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(1)
Endothelial cells (ECs) in the tumor microenvironment have been reported to play a more active role in solid tumor growth and metastatic dissemination than simply providing the physical structure to form conduits for blood flow; however, the involvem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::073f26f03a13d8f83fb590ae9248de75
https://pubmed.ncbi.nlm.nih.gov/28899878
https://pubmed.ncbi.nlm.nih.gov/28899878
Autor:
Yanru Wang, Fang Yang, Hui Xie, Li Quan, Wenwen Zhang, Lulu Cao, Zijia Sun, Hehui Fang, Shui Wang, Yucai Wang, Yan Li, Jan-Åke Gustafsson, Aiyu Zhu, Xiaoxiang Guan, Juan Jin
Publikováno v:
Carcinogenesis. 38(9)
Even with the identical clinicopathological features, the ability for metastasis is vastly different among triple-negative breast cancer (TNBC) patients. Intratumor heterogeneity (ITH), which is common in breast cancer, may be a key mechanism leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa22969e4f33aac604ad7a94c376cb32
https://pubmed.ncbi.nlm.nih.gov/28911002
https://pubmed.ncbi.nlm.nih.gov/28911002
Autor:
Wenwen Zhang, Jing Xu, Hehui Fang, Lin Tang, Weiwei Chen, Qian Sun, Qun Zhang, Fang Yang, Zijia Sun, Lulu Cao, Yucai Wang, Xiaoxiang Guan
Publikováno v:
FASEB Journal; 2018 Supplement, Vol. 32, p276-288, 13p