Výsledky vyhledávání

Discovery of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing a 4-oxo-pyridazinone moiety as potential c-Met kinase inhibitors

Autor: Xin Sun, Zunhua Yang, Qian Zhang, Xiaobo Liu, Pengwu Zheng, Binliang Zhang, Wufu Zhu, Shan Xu, Hehua Xiong

Publikováno v: New Journal of Chemistry. 44:9053-9063

Two series of [1,2,4]triazolo[4,3-a]pyrazine derivatives bearing 4-oxo-pyridazinone moieties (compounds 21a–l and 22a–l) were designed and their IC50 values were evaluated against three cancer cell lines (A549, MCF-7 and HeLa) and c-Met kinase. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1e1e7e0277573dfa8f617d6a97b0e87b
https://doi.org/10.1039/d0nj00575d

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Design, synthesis and biological evaluation of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment

Autor: Qidong Tang, Hehua Xiong, Yongli Duan, Han Zhang, Qian Zhang, Pengwu Zheng, Jianqing Zhang

Publikováno v: Bioorganicmedicinal chemistry letters. 30(9)

A series of 4-(pyridin-4-yloxy)benzamide derivatives bearing a 5-methylpyridazin-3(2H)-one fragment were designed, synthesized, and evaluated for their biological activity. Most compounds showed effective inhibitory activity against cancer cell lines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cad907a771090cb3dc563e217cd62c8
https://pubmed.ncbi.nlm.nih.gov/32173195

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Synthesis and antiproliferative activity of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 1,8-naphthyridin-2-one moiety

Autor: Zhen Xiao, Ping Gong, Duan Yongli, Qidong Tang, Linxiao Wang, Yinhua Xiong, Pengwu Zheng, Wufu Zhu, Shunmin Huang, Yueyue Xiao, Hehua Xiong, Ting Chen

Publikováno v: European Journal of Medicinal Chemistry. 158:201-213

A series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 1,8-naphthyridin-2-one moiety were designed, synthesized and evaluated for their biological activities. The target compounds exhibited moderate to high antiproliferative activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5cf925aefc2a536b514793988085d2
https://doi.org/10.1016/j.ejmech.2018.08.066

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Discovery of novel 2-substituted-4-phenoxypyridine derivatives as potential antitumor agents

Autor: Bingbing Zhao, Caolin Wang, Duan Yongli, Shifan Cai, Pengwu Zheng, Linxiao Wang, Yiqing Peng, Hehua Xiong, Shan Xu, Ping Wang, Qidong Tang, Rong Luo

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 28:254-259

A series of 2-substituted-4-phenoxypyridine derivatives were designed, synthesized, and evaluated for their antiproliferative activity against 4 cancer cell lines (A549, HT-29, H460, and U87MG) in vitro. Most compounds showed moderate to excellent po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68cc46fbf2c6d5e0216766bf23fd959
https://doi.org/10.1016/j.bmcl.2017.12.063

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Design, synthesis, antiproliferative activity and docking studies of quinazoline derivatives bearing oxazole or imidazole as potential EGFR inhibitors

Autor: Manli Zhang, Bingliang Zhang, Hehua Xiong, Zhen Xiao, Jiayi Hu, Bingbing Zhao, Caolin Wang, Ouyang Yiqiang, Pengwu Zheng, Wufu Zhu, Yanli Gao, Shan Xu

Publikováno v: New Journal of Chemistry. 42:17203-17215

Six series of quinazoline derivatives bearing oxazole or imidazole (8a–f, 9a–f, 10a–d, 11a–f, 12a–d and 13a–i) were designed, synthesized and their IC50 values evaluated against three cancer cell lines (A549, MCF-7 and PC-3). Most of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6bbaabbd4c2da7b7e1bc4de30aa41cfe
https://doi.org/10.1039/c8nj03594f

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Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety as potential antitumor inhibitor

Autor: Pengwu Zheng, Ting Chen, Qidong Tang, Shunmin Huang, Jianqing Zhang, Huimin Liu, Hehua Xiong, Yongli Duan

Publikováno v: Bioorganicmedicinal chemistry letters. 30(2)

A series of pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety were designed, synthesized and evaluated for the anti-proliferative on three cancer cell lines (A549, HepG2 and MCF-7) in vitro. Most of the compounds showed moderate to hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf3b1c4466bb452da3edb907d166de9
https://pubmed.ncbi.nlm.nih.gov/31836443

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Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment

Autor: Yongli Duan, Pengqin Chen, Jianqing Zhang, Yao Zeng, Hehua Xiong, Guang Liang, Di Wu, Qidong Tang, Hongmin Li

Publikováno v: European Journal of Medicinal Chemistry. 215:113273

In this study, a series of pyrrolo [2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment were synthesized and their biological activity were tested. Most of the target compounds displayed moderate to excellent activity against one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd75926228a88af0ff3b86ead16752dc
https://doi.org/10.1016/j.ejmech.2021.113273

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Design, synthesis and biological evaluation of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives as potential antitumor agents

Autor: Jianqing Zhang, Hehua Xiong, Qidong Tang, Dongxue Fu, Feiyi Yang, Ting Chen, Jie He, Pengwu Zheng

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 33:127740

Cancer is a major cause of death worldwide. Small molecule inhibitors have become a major therapeutic treatment for cancer. In this study, a series of novel 4-(pyrrolo[2,3-d]pyrimidine-4-yloxy)benzamide derivatives were designed, synthesized and eval

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d700e40b889dfa13b24b47e84b63ddc
https://doi.org/10.1016/j.bmcl.2020.127740

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