Orthogonal IMiD-Degron Pairs Induce Selective Protein Degradation in Cells.

Autor: Brennan PJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford; Oxford, UK.; Department of Chemistry & Biochemistry, University of California, Los Angeles; Los Angeles, USA., Saunders RE; GSK, Medicines Research Centre; Stevenage, UK., Spanou M; PerkinElmer; Beaconsfield, UK., Serafini M; Department of Chemistry, Chemistry Research Laboratory, University of Oxford; Oxford, UK., Sun L; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, USA., Heger GP; GSK, Medicines Research Centre; Stevenage, UK., Konopacka A; GSK, Medicines Research Centre; Stevenage, UK., Beveridge RD; Virus Screening Facility, Weatherall Institute of Molecular Medicine, University of Oxford; Oxford, UK., Gordon L; GSK, Medicines Research Centre; Stevenage, UK., Bunally SB; GSK, Medicines Research Centre; Stevenage, UK., Saudemont A; GSK, Medicines Research Centre; Stevenage, UK., Benowitz AB; GSK, Medicines Research Centre; Stevenage, UK., Martinez-Fleites C; GSK, Medicines Research Centre; Stevenage, UK., Queisser MA; GSK, Medicines Research Centre; Stevenage, UK., An H; Chemical Biology Program, Memorial Sloan Kettering Cancer Center; New York, USA., Deane CM; Department of Statistics, University of Oxford; Oxford, UK., Hann MM; GSK, Medicines Research Centre; Stevenage, UK., Brayshaw LL; GSK, Medicines Research Centre; Stevenage, UK., Conway SJ; Department of Chemistry, Chemistry Research Laboratory, University of Oxford; Oxford, UK.; Department of Chemistry & Biochemistry, University of California, Los Angeles; Los Angeles, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 16. Date of Electronic Publication: 2024 Mar 16.