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Akademický článek

Administration of recombinant FVIIa (rFVIIa) to concizumab-dosed monkeys is safe, and concizumab does not affect the potency of rFVIIa in hemophilic rabbits.

Autor: Lauritzen B; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Olling J; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Abel KL; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Augustsson C; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Balling K; Clinical Operations, Novo Nordisk A/S, Søborg, Denmark., Bjelke M; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Hegelund AC; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark., Hilden I; Global Drug Discovery, Novo Nordisk A/S, Måløv, Denmark.

Publikováno v: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2019 Mar; Vol. 17 (3), pp. 460-469. Date of Electronic Publication: 2019 Feb 20.

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Akademický článek

Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development.

Autor: Quadrini KJ; Research and Development Department, ICON Laboratory Services, Farmingdale, New York., Hegelund AC; Department of Development Bioanalysis, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Cortes KE; Research and Development Department, ICON Laboratory Services, Farmingdale, New York., Xue C; Research and Development Department, ICON Laboratory Services, Farmingdale, New York., Kennelly SM; Cellular Immunology, ICON Laboratory Services, Leopardstown, Dublin, Ireland., Ji H; Department of PharmacoDynamics, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Högerkorp CM; Department of PharmacoDynamics, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Mc Closkey TW; Research and Development Department, ICON Laboratory Services, Farmingdale, New York.

Publikováno v: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2016 Mar; Vol. 90 (2), pp. 177-90. Date of Electronic Publication: 2015 Sep 17.

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Akademický článek

A weighted method for estimation of receptor occupancy for pharmacodynamic measurements in drug development.

Autor: Sternebring O; Department of Development DMPK, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Alifrangis L; Department of Development DMPK, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Christensen TF; Department of Quantitative Clinical Pharmacology, Novo Nordisk A/S, DK-2860, Soeborg, Denmark., Ji H; Department of Pharmacodynamics, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Hegelund AC; Department of Development Bioanalysis, Novo Nordisk A/S, DK-2760, Maaloev, Denmark., Högerkorp CM; Department of Pharmacodynamics, Novo Nordisk A/S, DK-2760, Maaloev, Denmark.

Publikováno v: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2016 Mar; Vol. 90 (2), pp. 220-9. Date of Electronic Publication: 2015 Aug 31.

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Akademický článek

Surface-expressed insulin receptors as well as IGF-I receptors both contribute to the mitogenic effects of human insulin and its analogues.

Autor: Lundby A; Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark., Bolvig P; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Hegelund AC; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Hansen BF; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Worm J; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Lützen A; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Billestrup N; Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark., Bonnesen C; Diabetes Research Unit, Novo Nordisk A/S, Novo Nordisk Park, 2760, Maaloev, Denmark., Oleksiewicz MB; Centre for Biosecurity and Biopreparedness, Statens Serum Institute, Artillerivej 5, 2300, Copenhagen S, Denmark.

Publikováno v: Journal of applied toxicology : JAT [J Appl Toxicol] 2015 Jul; Vol. 35 (7), pp. 842-50. Date of Electronic Publication: 2014 Nov 21.

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Akademický článek

Systematic evaluation of the metabolic to mitogenic potency ratio for B10-substituted insulin analogues.

Autor: Glendorf T; Diabetes Research Unit, Novo Nordisk A/S, Maaloev, Denmark. tgle@novonordisk.com, Knudsen L, Stidsen CE, Hansen BF, Hegelund AC, Sørensen AR, Nishimura E, Kjeldsen T

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (2), pp. e29198. Date of Electronic Publication: 2012 Feb 22.

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Akademický článek

Molecular characterisation of long-acting insulin analogues in comparison with human insulin, IGF-1 and insulin X10.

Autor: Hansen BF; Diabetes Research Unit, Novo Nordisk A/S, Måløv, Denmark. bfh@novonordisk.com, Glendorf T, Hegelund AC, Lundby A, Lützen A, Slaaby R, Stidsen CE

Publikováno v: PloS one [PLoS One] 2012; Vol. 7 (5), pp. e34274. Date of Electronic Publication: 2012 May 08.

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Akademický článek

Comparison of intracellular signalling by insulin and the hypermitogenic AspB10 analogue in MCF-7 breast adenocarcinoma cells.

Autor: Oleksiewicz MB; Intercell AG, Campus Vienna Biocenter 3, 1030 Vienna, Austria. mboleks@gmail.com, Bonnesen C, Hegelund AC, Lundby A, Holm GM, Jensen MB, Krabbe JS

Publikováno v: Journal of applied toxicology : JAT [J Appl Toxicol] 2011 May; Vol. 31 (4), pp. 329-41. Date of Electronic Publication: 2010 Oct 08.

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Akademický článek

Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin.

Autor: Bonnesen C; Insulin Biology, Novo Nordisk Park C9.S.27, 2760, Maaloev, Denmark. crib@novonordisk.com, Nelander GM, Hansen BF, Jensen P, Krabbe JS, Jensen MB, Hegelund AC, Svendsen JE, Oleksiewicz MB

Publikováno v: Cell biology and toxicology [Cell Biol Toxicol] 2010 Aug; Vol. 26 (4), pp. 293-307. Date of Electronic Publication: 2009 Nov 08.

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Akademický článek

Glucagon-like Peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation.

Autor: Bjerre Knudsen L; Department of Biology and Pharmacology Mgt, Novo Nordisk A/S, Novo Nordisk Park, Maaloev DK-2760, Denmark. lbkn@novonordisk.com, Madsen LW, Andersen S, Almholt K, de Boer AS, Drucker DJ, Gotfredsen C, Egerod FL, Hegelund AC, Jacobsen H, Jacobsen SD, Moses AC, Mølck AM, Nielsen HS, Nowak J, Solberg H, Thi TD, Zdravkovic M, Moerch U

Publikováno v: Endocrinology [Endocrinology] 2010 Apr; Vol. 151 (4), pp. 1473-86. Date of Electronic Publication: 2010 Mar 04.

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