The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells.

Autor: Nabih HK; National Research Centre, Medical Biochemistry Department, 33 El-Bohouth St., Dokki, Giza 12622, Egypt., Yücer R; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Mahmoud N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Dawood M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; Department of Molecular Biology, Faculty of Medical Laboratory Science, Al-Neelain University, Khartoum, Sudan., Elbadawi M; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Shahhamzehei N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany., Atia MAM; Molecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center (ARC), Giza 12619, Egypt., AbdelSadik A; Zoology Department, Faculty of Science, Aswan University, 81528 Aswan, Egypt; Molecular Biotechnology Program, Faculty of Advanced Basic Sciences, Galala University, 43552, New Galala, Egypt., Hussien TA; Pharmacognosy Department, Faculty of Pharmacy, Sphinx University, New Assiut City, Assiut 10, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt; School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa., Klauck SM; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), and National Center for Tumor Diseases (NCT), Heidelberg, Germany., Hegazy MF; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany; National Research Centre, Chemistry of Medicinal Plants Department, 33 El-Bohouth St., Dokki, Giza 12622, Egypt. Electronic address: mohegazy@uni-mainz.de., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. Electronic address: efferth@uni-mainz.de.

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2024 Sep 27; Vol. 135, pp. 156023. Date of Electronic Publication: 2024 Sep 27.

Naturally Occurring Plant-Based Anticancerous Candidates as Potential ERK2 Inhibitors: In-Silico Database Mining and Molecular Dynamics Simulations.

Autor: Ibrahim MAA; Minia University, Chemistry Department, Chemistry Department, Faculty of Science,, Minia University, Minia, 61519, Minia, EGYPT., Ali SSM; Minia University, Chemistry Department, Chemistry Department, Faculty of Science,, Minia University, Minia, 61519, Minia, EGYPT., Abdelrahman AHM; Minia University, Chemistry Department, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt, 61519, Minia, EGYPT., Abdeljawaad KAA; Minia University, Chemistry Department, Chemistry Department, Faculty of Science,, Minia University, Minia, 61519, Minia, EGYPT., Sidhom PA; Tanta University, Department of Pharmaceutical Chemistry, Department of Pharmaceutical Chemistry, Faculty of Pharmacy,, Tanta University, 31527, Tanta, EGYPT., Sayed SRM; King Saud University, Department of Botany and Microbiology, Department of Botany and Microbiology, College of Science,, King Saud University,, P.O. Box 2455, 11451, Riyadh, SAUDI ARABIA., El-Tayeb MA; King Saud University, Department of Botany and Microbiology, Department of Botany and Microbiology, College of Science,, King Saud University, P.O. Box 2455, 11451, Riyadh, SAUDI ARABIA., Paré PW; Texas Tech University, Department of Chemistry & Biochemistry, Department of Chemistry & Biochemistry,, Texas Tech University, TX 79409, Lubbock, UNITED STATES., Hegazy MF; Johannes Gutenberg University, Department of Pharmaceutical Biology, Department of Pharmaceutical Biology,, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, GERMANY.

Publikováno v: Chemistry & biodiversity [Chem Biodivers] 2024 Jul 29, pp. e202401238. Date of Electronic Publication: 2024 Jul 29.

Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of Alzheimer's disease.

Autor: Hegazi NM; Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. nm.hegazi@nrc.sci.eg., Mohamed TA; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. tarik.nrc83@yahoo.com., Salama A; Pharmacology Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. berrotec@yahoo.com., Hamed AR; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. tarik.nrc83@yahoo.com., Saad HH; Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. nm.hegazi@nrc.sci.eg.; Department of Pharmaceutical Biology, Pharmaceutical Institute, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany., Saleh IA; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. tarik.nrc83@yahoo.com., Reda EH; Phytochemistry Laboratory, National Organization for Drug Control and Research, Giza 12622, Egypt. dremanhusseinreda@gmail.com., Elsayed AAA; Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. ahmedawad_888@yahoo.com., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt. m.ibrahim@compchem.net.; School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa., Paré PW; Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA. paul.pare@ttu.edu., Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences Chemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany. efferth@uni-mainz.de., Hegazy MF; Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt. tarik.nrc83@yahoo.com.

Publikováno v: Food & function [Food Funct] 2024 Apr 22; Vol. 15 (8), pp. 4354-4364. Date of Electronic Publication: 2024 Apr 22.

epi -Magnolin, a tetrahydrofurofuranoid lignan from the oleo-gum resin of Commiphora wightii , as inhibitor of pancreatic cancer cell proliferation, in-vitro and in-silico study.

Autor: Abd El-Razek MH; Chemistry of Natural Compounds Department, Institute of Pharmaceutical and Drug Industries Research, National Research Centre (NRC), Giza, Egypt., Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt., Al-Karmalawy AA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, 6th of October City, Giza, Egypt., Elrashedy AA; Department of the Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Institute, National Research Centre (NRC), Giza, Egypt., El-Desoky AH; Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), Giza, Egypt., Aboelmagd M; Pharmacognosy Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre (NRC), Giza, Egypt., Mohamed TA; Chemistry of Medicinal Plants Department, Institute of Pharmaceutical and Drug Industries Research, National Research Centre (NRC), Giza, Egypt., Hegazy MF; Chemistry of Medicinal Plants Department, Institute of Pharmaceutical and Drug Industries Research, National Research Centre (NRC), Giza, Egypt.

Publikováno v: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2024 Jan 24, pp. 1-13. Date of Electronic Publication: 2024 Jan 24.

Naturally Occurring Xanthones; Biological Activities, Chemical Profiles and In Silico Drug Discovery.

Autor: El-Seedi HR; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, 212013, China.; Department of Chemistry, Faculty of Science, Menoufia University, 32512, Shebin El-Kom, Egypt.; International Joint Research Laboratory of Intelligent Agriculture and Agri-Products Processing, Jiangsu Education Department, Jiangsu University, Nanjing, 210024, China., Ibrahim HMS; Department of Chemistry, Faculty of Science, Menoufia University, 32512, Shebin El-Kom, Egypt., Yosri N; Chemistry of Natural Products, Research Institute of Medicinal and Aromatic Plants (RIMAP), Beni-Suef University, Beni-Suef, 62514, Egypt., Ibrahim MAA; Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia, 61519, Egypt., Hegazy MF; Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Staudingerweg 5, Mainz, 55128, Germany.; 7Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza, 12622, Egypt., Setzer WN; Department of Chemistry, University of Alabama in Huntsville, Huntsville, 35899, AL, USA.; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, 84043, UT, USA., Guo Z; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China., Zou X; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China., Refaey MS; Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Menoufia 32897, Egypt., Salem SE; Clinical Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt., Musharraf SG; H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan., Saeed A; Chemistry Department, Quaid-i-Azam University, Islamabad, 45320, Pakistan., Salem SE; Faculty of Pharmacy, The British University in Egypt, El Sherouk, Cairo, Egypt., Xu B; Food Science and Technology Program, BNU-HKBU United International College, Zhuhai, 519087, China., Zhao C; College of Marine Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China., Khalifa SAM; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, SE 106 91, Sweden.

Publikováno v: Current medicinal chemistry [Curr Med Chem] 2024; Vol. 31 (1), pp. 62-101.