Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Autor: Raffaele Simeoli, Karli Montague, Hefin R. Jones, Laura Castaldi, David Chambers, Jayne H. Kelleher, Valentina Vacca, Thomas Pitcher, John Grist, Hadil Al-Ahdal, Liang-Fong Wong, Mauro Perretti, Johnathan Lai, Peter Mouritzen, Paul Heppenstall, Marzia Malcangio

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Exosomes are known to contain microRNAs (miRs). Here the authors show that dorsal root ganglion neurons release exosomes containing miR-21-5p, which contributes to inflammatory cell recruitment following peripheral nerve injury.

Externí odkaz: https://doaj.org/article/985f58856e554adfb658898c61646afe

Giant Circumflex Artery Aneurysm With a Coronary Sinus Fistula

Autor: Hefin R. Jones, David Wallbridge, Christopher M.R. Satur, Mark Gunning, Richard Libertini

Publikováno v: The Annals of Thoracic Surgery. 106:e223-e225

Giant coronary artery aneurysms are extremely rare entities, and the authors are aware of only 13 case reports of such aneurysms of the circumflex artery. This case report is provided to add evidence of the natural history and pathophysiology and des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05c3ff5a5b507c90d30155fa984dd79
https://doi.org/10.1016/j.athoracsur.2018.04.038

Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma

Autor: Valentina Vacca, Peter Mouritzen, John Grist, Laura Castaldi, Marzia Malcangio, Mauro Perretti, Paul A. Heppenstall, Hefin R. Jones, Johnathan Lai, Thomas Pitcher, Hadil Al-Ahdal, Jayne H. Kelleher, Raffaele Simeoli, Karli Montague, David J. Chambers, Liang-Fong Wong

Publikováno v: Nature Communications
Simeoli, R, Montague, K, Jones, H R, Castaldi, L, Chambers, D, Kelleher, J H, Vacca, V, Pitcher, T, Grist, J, Al-Ahdal, H, Wong, L-F, Perretti, M, Lai, J, Mouritzen, P, Heppenstall, P & Malcangio, M 2017, ' Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma ', Nature Communications, vol. 8, 1778 . https://doi.org/10.1038/s41467-017-01841-5
Simeoli, R, Montague, K, Jones, H R, Castaldi, L, Chambers, D, Kelleher, J H, Vacca, V, Pitcher, T, Grist, J, Al-Ahdal, H, Wong, L-F, Perretti, M, Lai, J, Mouritzen, P, Heppenstall, P & Malcangio, M 2017, ' Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma ', Nature Communications, vol. 8, no. 1, pp. 1778 . https://doi.org/10.1038/s41467-017-01841-5
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)

Following peripheral axon injury, dysregulation of non-coding microRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons. Here we show that DRG neuron cell bodies release extracellular vesicles, including exosomes containing miRs, upon acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90a7f8a51045615e2c81361993ac398
http://hdl.handle.net/20.500.11767/87764

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis

Autor: Patricia R. Souza, Francesco Dell'Accio, Elisa Corsiero, Alessandra Nerviani, Mauro Perretti, Lucy V. Norling, Sarah E. Headland, Lily Yeh Jan, Sonia Maria Oliani, Hefin R. Jones, Andrew Kim, Cristiane Damas Gil, Costantino Pitzalis

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

Made available in DSpace on 2018-12-11T17:00:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-11-25 Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51aca8d1e837d142575b3f07b70b3747
https://europepmc.org/articles/PMC6034622/

Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

Autor: Mauro Perretti, Gabrielle Fredman, Asma Nusrat, Nazila Kamaly, Hikaru Nishio, Ronen Sumagin, Hefin R. Jones, Ashfaqul Alam, Chris P. M. Reutelingsperger, Charles A. Parkos, Emile Rijcken, Andrew S. Neish, Philipp-Alexander Neumann, Miguel Quiros, Roland Hilgarth, Dennis H. M. Kusters, Omid C. Farokhzad, Ioannis Argyris, Giovanna Leoni

Publikováno v: Journal of Clinical Investigation, 125(3), 1215-1227. American Society for Clinical Investigation

Epithelial restitution is an essential process that is required to repair barrier function at mucosal surfaces following injury. Prolonged breaches in epithelial barrier function result in inflammation and further damage; therefore, a better understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ade1e76962c4788efc82d9aa901516e
https://cris.maastrichtuniversity.nl/en/publications/c9c2ae0f-b0e4-43ba-9342-1ecde09135bd