Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Heewon Park"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract In complex systems, it’s crucial to uncover latent mechanisms and their context-dependent relationships. This is especially true in medical research, where identifying unknown cancer mechanisms and their impact on phenomena like drug resis
Externí odkaz:
https://doaj.org/article/f3ec428d6dcc4ac9890534c10d6745c1
Autor:
Heewon Park, Satoru Miyano
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0305386 (2024)
Uncovering acquired drug resistance mechanisms has garnered considerable attention as drug resistance leads to treatment failure and death in patients with cancer. Although several bioinformatics studies developed various computational methodologies
Externí odkaz:
https://doaj.org/article/859ff55c83ab48fea4842aad24ccc816
Autor:
Heewon Park, Satoru Miyano
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3302 (2024)
Azacitidine, a DNA methylation inhibitor, is employed for the treatment of acute myeloid leukemia (AML). However, drug resistance remains a major challenge for effective azacitidine chemotherapy, though several studies have attempted to uncover the m
Externí odkaz:
https://doaj.org/article/88282f61a8844d428c163aecdd678aee
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-25 (2022)
Abstract Background Gene regulatory networks have garnered a large amount of attention to understand disease mechanisms caused by complex molecular network interactions. These networks have been applied to predict specific clinical characteristics, e
Externí odkaz:
https://doaj.org/article/4d858e2e25194ff6b370097d8a80f5c3
Autor:
Heewon Park
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12784 (2023)
Understanding complex disease mechanisms requires a comprehensive understanding of the gene regulatory networks, as complex diseases are often characterized by the dysregulation and dysfunction of molecular networks, rather than abnormalities in sing
Externí odkaz:
https://doaj.org/article/71368102b7a54a679daadebd55b77b58
Publikováno v:
PLoS ONE, Vol 18, Iss 8, p e0286044 (2023)
Biological condition-responsive gene network analysis has attracted considerable research attention because of its ability to identify pathways or gene modules involved in the underlying mechanisms of diseases. Although many condition-specific gene n
Externí odkaz:
https://doaj.org/article/2198f2fbb9ad4cb6a0635f2e970c7c1f
Autor:
Moo-Jun Kim, Jae-Wan Jeon, Hae-Ri Kim, Hyerim Park, Suyeon Han, Yunkyeong Hwang, Heewon Park, Kyungho Park, Eu-Jin Lee, Young-Rok Ham, Ki-Ryang Na, Kang-Wook Lee, Dae-Eun Choi
Publikováno v:
Diagnostics, Vol 13, Iss 15, p 2545 (2023)
Patients undergoing dialysis through a permanent catheter often experience infection or malfunction. However, few studies have clarified the predictors of permanent catheter patency survival in patients undergoing hemodialysis. We assessed the relati
Externí odkaz:
https://doaj.org/article/c77a0e2d7ac54268a77691e4090dda98
Publikováno v:
Gels, Vol 9, Iss 4, p 319 (2023)
Colon cancer is a significant health concern. The development of effective drug delivery systems is critical for improving treatment outcomes. In this study, we developed a drug delivery system for colon cancer treatment by embedding 6-mercaptopurine
Externí odkaz:
https://doaj.org/article/64839534e9aa49748e55ec9f00fd7e8b
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0261630 (2022)
In recent years, drug sensitivity prediction has garnered a great deal of attention due to the growing interest in precision medicine. Several computational methods have been developed for drug sensitivity prediction and the identification of related
Externí odkaz:
https://doaj.org/article/eb93b996da8d46aaa24e11c686330c4b
Autor:
Li Yang, Te Liang, Lane M. Pierson, Hongye Wang, Jesse K. Fletcher, Shu Wang, Duran Bao, Lili Zhang, Zhen Huang, Wenshu Zheng, Xiaomei Zhang, Heewon Park, Yuwen Li, James E. Robinson, Amy K. Feehan, Christopher J. Lyon, Jing Cao, Lisa A. Morici, Chenzhong Li, Chad J. Roy, Xiaobo Yu, Tony Hu
Publikováno v:
Research, Vol 2022 (2022)
Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites, but can be laborious. Herein, we employed peptide microarrays to map linear
Externí odkaz:
https://doaj.org/article/3c5565859db147acb09b4f31677d9342