Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Heesoo, Uhm"'
Autor:
Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Rho is a general transcription termination factor in bacteria. Here, Song et al. use single-molecule fluorescence assays to provide evidence that Rho-mediated transcription termination can occur via three kinetically different routes.
Externí odkaz:
https://doaj.org/article/b45db227dfd84b589754abd6da700e27
Autor:
Soochul Shin, Yoonseok Jung, Heesoo Uhm, Minseok Song, Soomin Son, Jiyoung Goo, Cherlhyun Jeong, Ji-Joon Song, V. Narry Kim, Sungchul Hohng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
MicroRNAs are potentially powerful biomarkers, though clinical use requires rapid and reliable profiling. Here the authors report amplification-free multicolour single-molecule imaging with single base mismatch sensitivity.
Externí odkaz:
https://doaj.org/article/a1f97de236b54183ad3bf6dbebd4a004
Autor:
Wooyoung Kang, Kook Sun Ha, Heesoo Uhm, Kyuhyong Park, Ja Yil Lee, Sungchul Hohng, Changwon Kang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Bacterial transcription is terminated when RNA polymerases encounter terminator sequences. Using a single-molecule fluorescence assay, here the authors show that the release of transcript RNA precedes RNA polymerase dissociation and that the remainin
Externí odkaz:
https://doaj.org/article/d97e30411e7f425eab5086b9c09f7d1c
Autor:
Nam-Kyung Yu, Heesoo Uhm, Jaehoon Shim, Jun-Hyeok Choi, Sangsu Bae, Todd Charlton Sacktor, Sungchul Hohng, Bong-Kiun Kaang
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-7 (2017)
Abstract Protein kinase M zeta (PKMζ), a constitutively active, atypical protein kinase C isoform, maintains a high level of expression in the brain after the induction of learning and long-term potentiation (LTP). Further, its overexpression enhanc
Externí odkaz:
https://doaj.org/article/e2138c1ae7394b2b94a81239fe67ae46
Autor:
Eunho Song, Heesoo Uhm, Seungha Hwang, Palinda R. Munasingha, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Publikováno v:
Biophysical Journal. 122:150a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7974dcc99de5ff8eda195eafdd7e659
https://doi.org/10.1016/j.bpj.2022.11.1008
https://doi.org/10.1016/j.bpj.2022.11.1008
Autor:
Eunho Song, Heesoo Uhm, Palinda Ruvan Munasingha, Seungha Hwang, Yeon-Soo Seo, Jin Young Kang, Changwon Kang, Sungchul Hohng
Publikováno v:
Nature communications. 13(1)
Rho is a general transcription termination factor in bacteria, but many aspects of its mechanism of action are unclear. Diverse models have been proposed for the initial interaction between the RNA polymerase (RNAP) and Rho (catch-up and stand-by pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee4c0ae9d43ad31e7f6c8ca845ed909
https://pubmed.ncbi.nlm.nih.gov/35351884
https://pubmed.ncbi.nlm.nih.gov/35351884
Autor:
Heesoo Uhm, Ji-Joon Song, Cherlhyun Jeong, Jiyoung Goo, Soomin Son, V. Narry Kim, Yoonseok Jung, Sungchul Hohng, Soochul Shin, Minseok Song
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
MicroRNAs (miRNAs) are short (19–24 nt) non-coding RNAs that suppress the expression of protein coding genes at the post-transcriptional level. Differential expression profiles of miRNAs across a range of diseases have emerged as powerful biomarker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84369d3732f93eecee200b20424d4735
http://europepmc.org/articles/PMC7699633
http://europepmc.org/articles/PMC7699633
Publikováno v:
Nucleic Acids Research
The RNA polymerase (RNAP) clamp, a mobile structural element conserved in RNAP from all domains of life, has been proposed to play critical roles at different stages of transcription. In previous work, we demonstrated using single-molecule Förster r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d22cec49f309bda9feb2acff171745
https://doi.org/10.1101/2020.10.06.327965
https://doi.org/10.1101/2020.10.06.327965
Autor:
Kyuhyong Park, Kook Sun Ha, Wooyoung Kang, Heesoo Uhm, Ja Yil Lee, Changwon Kang, Sungchul Hohng
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc29f441dba6bf985278fad6916a21d
http://europepmc.org/articles/PMC6978380
http://europepmc.org/articles/PMC6978380
Autor:
Heesoo, Uhm, Sungchul, Hohng
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2106
Cotranscriptional RNA folding plays important roles in gene regulation steps such as splicing, transcription termination, and translation initiation. Progression of our understanding of cotranscriptional RNA folding mechanisms is still retarded by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b30421dbaac2f30d7e1c36fedb41440f
https://pubmed.ncbi.nlm.nih.gov/31889264
https://pubmed.ncbi.nlm.nih.gov/31889264