Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells

Autor: Collins Hilary M, Abdelghany Magdy K, Messmer Marie, Yue Baigong, Deeves Sian E, Kindle Karin B, Mantelingu Kempegowda, Aslam Akhmed, Winkler G Sebastiaan, Kundu Tapas K, Heery David M

Publikováno v: BMC Cancer, Vol 13, Iss 1, p 37 (2013)

Abstract Background Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade and poor survival in br

Externí odkaz: https://doaj.org/article/99ad2d622528444c94d5485050018ba5

Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer

Autor: Monteiro, Patrícia F., Gulfam, Muhammad, Monteiro, Cíntia J., Travanut, Alessandra, Abelha, Thais Fedatto, Pearce, Amanda K., Jerôme, Christine, Grabowska, Anna M., Clarke, Philip A., Collins, Hilary M., Heery, David M., Gershkovich, Pavel, Alexander, Cameron

Publikováno v: In Journal of Controlled Release 10 July 2020 323:549-564

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Autor: Vitale, Ilio, Pietrocola, Federico, Guilbaud, Emma, Aaronson, Stuart A, Abrams, John M, Adam, Dieter, Agostini, Massimiliano, Agostinis, Patrizia, Alnemri, Emad S, Altucci, Lucia, Amelio, Ivano, Andrews, David W, Aqeilan, Rami I, Arama, Eli, Baehrecke, Eric H, Balachandran, Siddharth, Bano, Daniele, Barlev, Nickolai A, Bartek, Jiri, Bazan, Nicolas G, Becker, Christoph, Bernassola, Francesca, Bertrand, Mathieu J M, Bianchi, Marco E, Blagosklonny, Mikhail V, Blander, J Magarian, Blandino, Giovanni, Blomgren, Klas, Borner, Christoph, Bortner, Carl D, Bove, Pierluigi, Boya, Patricia, Brenner, Catherine, Broz, Petr, Brunner, Thomas, Damgaard, Rune Busk, Calin, George A, Campanella, Michelangelo, Candi, Eleonora, Carbone, Michele, Carmona-Gutierrez, Didac, Cecconi, Francesco, Chan, Francis K-M, Chen, Guo-Qiang, Chen, Quan, Chen, Youhai H, Cheng, Emily H, Chipuk, Jerry E, Cidlowski, John A, Ciechanover, Aaron, Ciliberto, Gennaro, Conrad, Marcus, Cubillos-Ruiz, Juan R, Czabotar, Peter E, D'Angiolella, Vincenzo, Daugaard, Mads, Dawson, Ted M, Dawson, Valina L, De Maria, Ruggero, De Strooper, Bart, Debatin, Klaus-Michael, Deberardinis, Ralph J, Degterev, Alexei, Del Sal, Giannino, Deshmukh, Mohanish, Di Virgilio, Francesco, Diederich, Marc, Dixon, Scott J, Dynlacht, Brian D, El-Deiry, Wafik S, Elrod, John W, Engeland, Kurt, Fimia, Gian Maria, Galassi, Claudia, Ganini, Carlo, Garcia-Saez, Ana J, Garg, Abhishek D, Garrido, Carmen, Gavathiotis, Evripidis, Gerlic, Motti, Ghosh, Sourav, Green, Douglas R, Greene, Lloyd A, Gronemeyer, Hinrich, Häcker, Georg, Hajnóczky, György, Hardwick, J Marie, Haupt, Ygal, He, Sudan, Heery, David M, Hengartner, Michael O, Hetz, Claudio, Hildeman, David A, Ichijo, Hidenori, Inoue, Satoshi, Jäättelä, Marja, Janic, Ana, Joseph, Bertrand, Jost, Philipp J, Kanneganti, Thirumala-Devi, Karin, Michael, Kashkar, Hamid, Kaufmann, Thomas, Kelly, Gemma L, Kepp, Oliver, Kimchi, Adi, Kitsis, Richard N, Klionsky, Daniel J, Kluck, Ruth, Krysko, Dmitri V, Kulms, Dagmar, Kumar, Sharad, Lavandero, Sergio, Lavrik, Inna N, Lemasters, John J, Liccardi, Gianmaria, Linkermann, Andreas, Lipton, Stuart A, Lockshin, Richard A, López-Otín, Carlos, Luedde, Tom, MacFarlane, Marion, Madeo, Frank, Malorni, Walter, Manic, Gwenola, Mantovani, Roberto, Marchi, Saverio, Marine, Jean-Christophe, Martin, Seamus J, Martinou, Jean-Claude, Mastroberardino, Pier G, Medema, Jan Paul, Mehlen, Patrick, Meier, Pascal, Melino, Gerry, Melino, Sonia, Miao, Edward A, Moll, Ute M, Muñoz-Pinedo, Cristina, Murphy, Daniel J, Niklison-Chirou, Maria Victoria, Novelli, Flavia, Núñez, Gabriel, Oberst, Andrew, Ofengeim, Dimitry, Opferman, Joseph T, Oren, Moshe, Pagano, Michele, Panaretakis, Theocharis, Pasparakis, Manolis, Penninger, Josef M, Pentimalli, Francesca, Pereira, David M, Pervaiz, Shazib, Peter, Marcus E, Pinton, Paolo, Porta, Giovanni, Prehn, Jochen H M, Puthalakath, Hamsa, Rabinovich, Gabriel A, Rajalingam, Krishnaraj, Ravichandran, Kodi S, Rehm, Markus, Ricci, Jean-Ehrland, Rizzuto, Rosario, Robinson, Nirmal, Rodrigues, Cecilia M P, Rotblat, Barak, Rothlin, Carla V, Rubinsztein, David C, Rudel, Thomas, Rufini, Alessandro, Ryan, Kevin M, Sarosiek, Kristopher A, Sawa, Akira, Sayan, Emre, Schroder, Kate, Scorrano, Luca, Sesti, Federico, Shao, Feng, Shi, Yufang, Sica, Giuseppe S, Silke, John, Simon, Hans-Uwe, Sistigu, Antonella, Stephanou, Anastasis, Stockwell, Brent R, Strapazzon, Flavie, Strasser, Andreas, Sun, Liming, Sun, Erwei, Sun, Qiang, Szabadkai, Gyorgy, Tait, Stephen W G, Tang, Daolin, Tavernarakis, Nektarios, Troy, Carol M, Turk, Boris, Urbano, Nicoletta, Vandenabeele, Peter, Vanden Berghe, Tom, Vander Heiden, Matthew G, Vanderluit, Jacqueline L, Verkhratsky, Alexei, Villunger, Andreas, von Karstedt, Silvia, Voss, Anne K, Vousden, Karen H, Vucic, Domagoj, Vuri, Daniela, Wagner, Erwin F, Walczak, Henning, Wallach, David, Wang, Ruoning, Wang, Ying, Weber, Achim, Wood, Will, Yamazaki, Takahiro, Yang, Huang-Tian, Zakeri, Zahra, Zawacka-Pankau, Joanna E, Zhang, Lin, Zhang, Haibing, Zhivotovsky, Boris, Zhou, Wenzhao, Piacentini, Mauro, Kroemer, Guido, Galluzzi, Lorenzo

Publikováno v: Vitale, I, Pietrocola, F, Guilbaud, E, Aaronson, S A, Abrams, J M, Adam, D, Agostini, M, Agostinis, P, Alnemri, E S, Altucci, L, Amelio, I, Andrews, D W, Aqeilan, R I, Arama, E, Baehrecke, E H, Balachandran, S, Bano, D, Barlev, N A, Bartek, J, Bazan, N G, Becker, C, Bernassola, F, Bertrand, M J M, Bianchi, M E, Blagosklonny, M V, Blander, J M, Blandino, G, Blomgren, K, Borner, C, Bortner, C D, Bove, P, Boya, P, Brenner, C, Broz, P, Brunner, T, Damgaard, R B, Calin, G A, Campanella, M, Candi, E, Carbone, M, Carmona-Gutierrez, D, Cecconi, F, Chan, F K M, Chen, G Q, Chen, Q, Chen, Y H, Cheng, E H, Chipuk, J E, Cidlowski, J A, Ciechanover, A, Ciliberto, G, Conrad, M, Cubillos-Ruiz, J R, Czabotar, P E, D’Angiolella, V, Daugaard, M, Dawson, T M, Dawson, V L, De Maria, R, De Strooper, B, Debatin, K M, Deberardinis, R J, Degterev, A, Del Sal, G, Deshmukh, M, Di Virgilio, F, Diederich, M, Dixon, S J, Dynlacht, B D, El-Deiry, W S, Elrod, J W, Engeland, K, Fimia, G M, Galassi, C, Ganini, C, Garcia-Saez, A J, Garg, A D, Garrido, C, Gavathiotis, E, Gerlic, M, Ghosh, S, Green, D R, Greene, L A, Gronemeyer, H, Häcker, G, Hajnóczky, G, Hardwick, J M, Haupt, Y, He, S, Heery, D M, Hengartner, M O, Hetz, C, Hildeman, D A, Ichijo, H, Inoue, S, Jäättelä, M, Janic, A, Joseph, B, Jost, P J, Kanneganti, T D, Karin, M, Kashkar, H, Kaufmann, T, Kelly, G L, Kepp, O, Kimchi, A, Kitsis, R N, Klionsky, D J, Kluck, R, Krysko, D V, Kulms, D, Kumar, S, Lavandero, S, Lavrik, I N, Lemasters, J J, Liccardi, G, Linkermann, A, Lipton, S A, Lockshin, R A, López-Otín, C, Luedde, T, MacFarlane, M, Madeo, F, Malorni, W, Manic, G, Mantovani, R, Marchi, S, Marine, J C, Martin, S J, Martinou, J C, Mastroberardino, P G, Medema, J P, Mehlen, P, Meier, P, Melino, G, Melino, S, Miao, E A, Moll, U M, Muñoz-Pinedo, C, Murphy, D J, Niklison-Chirou, M V, Novelli, F, Núñez, G, Oberst, A, Ofengeim, D, Opferman, J T, Oren, M, Pagano, M, Panaretakis, T, Pasparakis, M, Penninger, J M, Pentimalli, F, Pereira, D M, Pervaiz, S, Peter, M E, Pinton, P, Porta, G, Prehn, J H M, Puthalakath, H, Rabinovich, G A, Rajalingam, K, Ravichandran, K S, Rehm, M, Ricci, J E, Rizzuto, R, Robinson, N, Rodrigues, C M P, Rotblat, B, Rothlin, C V, Rubinsztein, D C, Rudel, T, Rufini, A, Ryan, K M, Sarosiek, K A, Sawa, A, Sayan, E, Schroder, K, Scorrano, L, Sesti, F, Shao, F, Shi, Y, Sica, G S, Silke, J, Simon, H U, Sistigu, A, Stephanou, A, Stockwell, B R, Strapazzon, F, Strasser, A, Sun, L, Sun, E, Sun, Q, Szabadkai, G, Tait, S W G, Tang, D, Tavernarakis, N, Troy, C M, Turk, B, Urbano, N, Vandenabeele, P, Vanden Berghe, T, Vander Heiden, M G, Vanderluit, J L, Verkhratsky, A, Villunger, A, von Karstedt, S, Voss, A K, Vousden, K H, Vucic, D, Vuri, D, Wagner, E F, Walczak, H, Wallach, D, Wang, R, Wang, Y, Weber, A, Wood, W, Yamazaki, T, Yang, H T, Zakeri, Z, Zawacka-Pankau, J E, Zhang, L, Zhang, H, Zhivotovsky, B, Zhou, W, Piacentini, M, Kroemer, G & Galluzzi, L 2023, ' Apoptotic cell death in disease—Current understanding of the NCCD 2023 ', Cell Death and Differentiation, vol. 30, no. 5, pp. 1097-1154 . https://doi.org/10.1038/s41418-023-01153-w
Cell death and differentiation 30(5), 1097-1154 (2023). doi:10.1038/s41418-023-01153-w

58 p.-5 fig.-7 box.
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2b742266215ffe65e96dc332753aba
https://orbit.dtu.dk/en/publications/0f60f683-cf55-4ff1-9d52-631620c6ad87

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PIP5K1? is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer

Autor: Wang, Tianyan, Sarwar, Martuza, Whitchurch, Jonathan B., Collins, Hilary M., Green, Tami, Semenas, Julius, Ali, Amjad, Roberts, Christopher J., Morris, Ryan D., Hubert, Madlen, Chen, Sa, El-Schich, Zahra, Wingren, Anette G., Lundmark, Richard, Mongan, Nigel P., Gunhaga, Lena, Heery, David M., Persson, Jenny L.

PIP5K1? has emerged as a promising drug target for the treatment of castration-resistant prostate cancer (CRPC), as it acts upstream of the PI3K/AKT signaling pathway to promote prostate cancer (PCa) growth, survival and invasion. However, little is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::aec80678e4e9c78f89b5b0a56bffd437