Complement is increased in treatment resistant rectal cancer and modulates radioresistance.

Autor: O'Brien RM; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: obrier30@tcd.ie., Meltzer S; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway. Electronic address: sebastian.meltzer@medisin.uio.no., Buckley CE; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: BUCKLECR@tcd.ie., Heeran AB; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: HEERANA@tcd.ie., Nugent TS; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: nugentti@tcd.ie., Donlon NE; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Department of Surgery, Beacon Hospital, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: DONLONN@tcd.ie., Reynolds JV; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: reynoljv@tcd.ie., Ree AH; Department of Oncology, Akershus University Hospital, 1478 Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: a.h.ree@medisin.uio.no., Redalen KR; Department of Physics, Norwegian University of Science and Technology, 7491 Trondheim, Norway. Electronic address: kathrine.redalen@ntnu.no., Hafeez A; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: adnan.hafeez@beaconhospital.ie., O'Ríordáin DS; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: diarmuid@dorconsultants.com., Hannon RA; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: robert.hannon@beaconhospital.ie., Neary P; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: Paulcneary@msn.com., Kalbassi R; Department of Surgery, Beacon Hospital, Dublin, Ireland. Electronic address: kalbassir@yahoo.com., Mehigan BJ; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: BMehigan@stjames.ie., McCormick PH; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: PMcCormick@stjames.ie., Dunne C; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: caramdunne@gmail.com., Kelly ME; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: KELLYM11@tcd.ie., Larkin JO; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland; Gastrointestinal Medicine and Surgery (GEMS) Directorate, St. James's Hospital, Dublin, Ireland. Electronic address: larkin.dundalk@gmail.com., O'Sullivan J; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: osullij4@tcd.ie., Lysaght J; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin 8, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: jlysaght@tcd.ie., Lynam-Lennon N; Department of Surgery, School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, Ireland; Trinity St. James's Cancer Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland. Electronic address: lynamlen@tcd.ie.

Publikováno v: Cancer letters [Cancer Lett] 2024 Nov 01; Vol. 604, pp. 217253. Date of Electronic Publication: 2024 Sep 14.

Visceral adipose tissue secretome from early and late-stage oesophageal cancer patients differentially affects effector and regulatory T cells.

Autor: Davern M; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Bracken-Clarke D; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Donlon NE; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Sheppard AD; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Connell FO; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Heeran AB; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Majcher K; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Conroy MJ; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Mylod E; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Butler C; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Donohoe C; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Donnell DO; Department of Clinical Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Dublin 8, Ireland., Lowery M; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Bhardwaj A; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Ravi N; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Melo AA; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland., Sullivan JO; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Reynolds JV; Department of Surgery, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, St. James's Hospital, Trinity College Dublin, Dublin, Ireland., Lysaght J; Cancer Immunology and Immunotherapy Group, Department of Surgery, School of Medicine, Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Dublin 8, Ireland. jlysaght@tcd.ie.

Publikováno v: Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2023 Aug; Vol. 149 (9), pp. 6583-6599. Date of Electronic Publication: 2023 Feb 15.

Energy Metabolism, Metabolite, and Inflammatory Profiles in Human Ex Vivo Adipose Tissue Are Influenced by Obesity Status, Metabolic Dysfunction, and Treatment Regimes in Patients with Oesophageal Adenocarcinoma.

Autor: O'Connell F; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Mylod E; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland.; Cancer Immunology and Immunotherapy Group, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Donlon NE; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland.; Cancer Immunology and Immunotherapy Group, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Heeran AB; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Butler C; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Bhardwaj A; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Ramjit S; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Durand M; Department of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Lambe G; Department of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Tansey P; Department of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Welartne I; Department of Radiology, St. James's Hospital, D08 NHY1 Dublin, Ireland., Sheahan KP; Department of Radiology, Beaumont Hospital, D02 YN77 Dublin, Ireland., Yin X; UCD School of Agriculture and Food Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland., Donohoe CL; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Ravi N; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Dunne MR; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland.; School of Chemical & Biopharmaceutical Sciences, Technological University Dublin, Tallaght, D07 EWV4 Dublin, Ireland., Brennan L; UCD School of Agriculture and Food Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland., Reynolds JV; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland., Roche HM; Nutrigenomics Research Group, UCD Conway Institute, School of Public Health, Physiotherapy and Sports Science, University College Dublin, D04 C1P1 Dublin, Ireland.; Institute for Global Food Security, School of Biological Sciences, Queens University Belfast, Belfast BT9 5DL, UK., O'Sullivan J; Department of Surgery, Trinity St. James's Cancer Institute and Trinity Translational Medicine Institute, St. James's Hospital and Trinity College Dublin, D08 W9RT Dublin, Ireland.

Publikováno v: Cancers [Cancers (Basel)] 2023 Mar 09; Vol. 15 (6). Date of Electronic Publication: 2023 Mar 09.

Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction.

Autor: Heeran AB; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., McCready J; Department of Biological and Physical Sciences, Assumption University, Worcester, MA 01609, USA., Dunne MR; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Donlon NE; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Nugent TS; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Bhardwaj A; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Mitchelson KAJ; Nutrigenomics Research Group, School of Public Health, Physiotherapy and Sports Science, UCD Conway Institute, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland., Buckley AM; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Ravi N; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Roche HM; Nutrigenomics Research Group, School of Public Health, Physiotherapy and Sports Science, UCD Conway Institute, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.; Institute for Global Food Security, Queens University Belfast, Belfast BT9 5DL, UK., Reynolds JV; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., Lynam-Lennon N; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland., O'Sullivan J; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, St. James's Hospital, D08 W9RT Dublin, Ireland.

Publikováno v: Metabolites [Metabolites] 2021 Nov 10; Vol. 11 (11). Date of Electronic Publication: 2021 Nov 10.

The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses.

Autor: Heeran AB; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Dunne MR; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Morrissey ME; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Buckley CE; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Clarke N; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Cannon A; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Donlon NE; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Nugent TS; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., Durand M; GEMS, St. James's Hospital, D08 NHY1 Dublin 8, Ireland., Dunne C; GEMS, St. James's Hospital, D08 NHY1 Dublin 8, Ireland., Larkin JO; GEMS, St. James's Hospital, D08 NHY1 Dublin 8, Ireland., Mehigan B; GEMS, St. James's Hospital, D08 NHY1 Dublin 8, Ireland., McCormick P; GEMS, St. James's Hospital, D08 NHY1 Dublin 8, Ireland., Lynam-Lennon N; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland., O'Sullivan J; Trinity St. James's Cancer Institute, Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James's Hospital, D08 W9RT Dublin 8, Ireland.

Publikováno v: Cancers [Cancers (Basel)] 2021 Feb 02; Vol. 13 (3). Date of Electronic Publication: 2021 Feb 02.