Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Heenam Stanley Kim"'
Autor:
Da-Eun Cho, Joon-Pyo Hong, Yoongeun Kim, Ju Yeon Sim, Heenam Stanley Kim, Song-rae Kim, Bombi Lee, Hyo-Sung Cho, Ik-Hyun Cho, Sooan Shin, Mijung Yeom, Soon-Kyeong Kwon, In-Seon Lee, Hijoon Park, Kyuseok Kim, Dae-Hyun Hahm
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Psychological stress and intestinal leakage are key factors in atopic dermatitis (AD) recurrence and exacerbation. Here, we demonstrate the mechanism underlying bacterial translocation across intestinal epithelial barrier damaged due to stre
Externí odkaz:
https://doaj.org/article/acd0234d8d35461492bffdcd7b648c23
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT β-Lactamase production facilitates bacterial survival in nature and affects many infection therapies. However, much of its regulation remains unexplored. We used a genetics-based approach to identify a two-component system (TCS) present in
Externí odkaz:
https://doaj.org/article/123c08be02a74610bfc1341d13e6b38a
Autor:
Heenam Stanley Kim
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Coronavirus disease 2019 (COVID-19), which has been declared a pandemic, has exhibited a wide range of severity worldwide. Although this global variation is largely affected by socio-medical situations in each country, there is also high individual-l
Externí odkaz:
https://doaj.org/article/ed2751970d584a8481a0374ab7d48375
Autor:
Thinh-Phat Cao, Hyojeong Yi, Immanuel Dhanasingh, Suparna Ghosh, Jin Myung Choi, Kun Ho Lee, Seol Ryu, Heenam Stanley Kim, Sung Haeng Lee
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Despite class A ESBLs carrying substitutions outside catalytic regions, such as Cys69Tyr or Asn136Asp, have emerged as new clinical threats, the molecular mechanisms underlying their acquired antibiotics-hydrolytic activity remains unclear. We discov
Externí odkaz:
https://doaj.org/article/9a8d7039b8654a458907a0e9ce315499
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004640 (2014)
Expansion or shrinkage of existing tandem repeats (TRs) associated with various biological processes has been actively studied in both prokaryotic and eukaryotic genomes, while their origin and biological implications remain mostly unknown. Here we d
Externí odkaz:
https://doaj.org/article/f05d760cfb9342f2b0e2c425d10a50a9
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37585 (2012)
The continuous evolution of β-lactamases resulting in bacterial resistance to β-lactam antibiotics is a major concern in public health, and yet the underlying molecular basis or the pattern of such evolution is largely unknown. We investigated the
Externí odkaz:
https://doaj.org/article/47190b704b89498294471fc24515f106
Autor:
Han Song, Junghyun Hwang, Hyojeong Yi, Ricky L Ulrich, Yan Yu, William C Nierman, Heenam Stanley Kim
Publikováno v:
PLoS Pathogens, Vol 6, Iss 5, p e1000922 (2010)
The equine-associated obligate pathogen Burkholderia mallei was developed by reductive evolution involving a substantial portion of the genome from Burkholderia pseudomallei, a free-living opportunistic pathogen. With its short history of divergence
Externí odkaz:
https://doaj.org/article/2e4d5d4e5c0545f48e9639968eda1a97
Publikováno v:
Antimicrob Agents Chemother
Highly conserved PenI-type class A β-lactamase in pathogenic members of Burkholderia species can evolve to extended-spectrum β-lactamase (ESBL), which exhibits hydrolytic activity toward third-generation cephalosporins, while losing its activity to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824e67dfcbc0dba5aa1cf4aa9622a1af
https://doi.org/10.1128/aac.02252-19
https://doi.org/10.1128/aac.02252-19
Publikováno v:
Journal of Antimicrobial Chemotherapy. 73:332-338
Objectives Although meropenem is widely used to treat Burkholderia infections, the response of Burkholderia pathogens to this antibiotic is largely unexplored. Methods Burkholderia thailandensis, a model for Burkholderia spp., particularly Burkholder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed24ed786f7d4c03e2e8fd4109ae2841
https://doi.org/10.1093/jac/dkx378
https://doi.org/10.1093/jac/dkx378
Autor:
Hyojeong Yi, Heenam Stanley Kim
Publikováno v:
Trends in Microbiology. 26:735-737
Current research is primarily focused on compositional shifts and alterations in the metabolic status of the gut microbiota to elucidate the damage caused by antibiotics. However, the impact of the stringent response, which is governed by a global ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df69faf6152a6fa17632c75a3d96a34
https://doi.org/10.1016/j.tim.2018.06.003
https://doi.org/10.1016/j.tim.2018.06.003