Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter.

Autor: Beekman M; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands., Schutte BAM; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands., Akker EBVD; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.; The Delft Bioinformatics Lab, Delft University of Technology, Delft, 2628CD, The Netherlands., Noordam R; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Dibbets-Schneider P; Department of Radiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., de Geus-Oei LF; Department of Radiology, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Deelen J; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.; Max Planck Institute for Biology of Ageing, Cologne, D-50931, Germany., Rest OV; Divison of Human Nutrition and Health, Wageningen University & Research, Wageningen, 6700EV, The Netherlands., Heemst DV; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2333ZA, The Netherlands., Feskens EJM; Divison of Human Nutrition and Health, Wageningen University & Research, Wageningen, 6700EV, The Netherlands., Slagboom PE; Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, 2333ZC, The Netherlands.

Publikováno v: Molecular nutrition & food research [Mol Nutr Food Res] 2020 May; Vol. 64 (10), pp. e1900818. Date of Electronic Publication: 2020 Apr 23.

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.

Autor: Jiang X; Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.; Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels vagen 13, Stockholm, 17177, Sweden., O'Reilly PF; Department of Social Genetic & Developmental Psychiatry, King's College London, Institute of Psychiatry, De Crespigny Park, London, SE5 8AF, UK., Aschard H; Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA.; Centre de Bioinformatique, Biostatistique et Biologie Intégrative (C3BI), Institut Pasteur, Paris, 75724, France., Hsu YH; Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA.; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, 02142, USA., Richards JB; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, 3755 Côte Ste-Catherine Road, Suite H-413 Montréal, Québec, H3T 1E2, Canada., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.; Framingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA, 01702, USA., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine Stanford, Stanford, CA, 94305, USA.; Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden., Karasik D; Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA., Pilz S; Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria., Berry D; Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK., Kestenbaum B; Kidney Research Institute, Division of Nephrology, 325 Ninth Avenue, Seattle, WA, 98104, USA., Zheng J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Sofianopoulou E; Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Streeten EA; Genetics and Personalized Medicine Program, University of Maryland School of Medicine, Howard Hall Room 567, Baltimore, MD, 21201, USA., Albanes D; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA., Lutsey PL; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA., Yao L; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA., Tang W; Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, 1300S 2nd Street, Suite 300, Minneapolis, MN, 55454, USA., Econs MJ; Department of Medicine, Indiana University, Endocrinology, 1120W Michigan Street, Indianapolis, IN, 46202-5124, USA., Wallaschofski H; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17489, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 13316, Berlin, Germany., Völzke H; DZHK (German Centre for Cardiovascular Research), Partner Site, Greifswald, 13316, Berlin, Germany.; Institut für Community Medicine, SHIP/Klinisch-Epidemiologische Forschung, Universitätsmedizin Greifswald, Walther-Rathenau-Str. 48, 17475, Greifswald, Germany., Zhou A; Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, 5001, SA, Australia., Power C; Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK., McCarthy MI; Oxford Centre for Diabetes Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK.; Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LJ, UK., Michos ED; Division of Cardiology, Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, MD, 21287, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, 77030, USA., Weinstein SJ; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA., Freedman ND; Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA., Huang WY; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 9609 Medical Center Drive, Bethesda, MD, 20892, USA., Van Schoor NM; Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, De Boelelaan 1089a, 1081 HV, Amsterdam, The Netherlands., van der Velde N; Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.; AMC, Internal Medicine, Geriatrics Department, PO Box 22700, 1100 DE, Amsterdam, The Netherlands., Groot LCPGM; Department of Human Nutrition, Wageningen University, PO-box 17, 6700 AA, Wageningen, The Netherlands., Enneman A; Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA.; Framingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA, 01702, USA., Booth SL; Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA., Vasan RS; Framingham Heart Study, 73 Mt. Wayte Avenue, Framingham, MA, 01702, USA., Liu CT; Department of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Crosstown Center. 801 Massachusetts Avenue 3rd Floor, Boston, MA, 02118, USA., Ripatti S; Statistical and Translational Genetics, University of Helsinki, Tukholmankatu 8, Building, Biomedicum, Helsinki 2U, Finland., Ohlsson C; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Vita Stråket 11, Gothenburg, 41345, Sweden., Vandenput L; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Vita Stråket 11, Gothenburg, 41345, Sweden., Lorentzon M; Department of Geriatric Medicine, University of Gothenburg and Sahlgrenska University Hospital, Mölndal, 43180, Sweden., Eriksson JG; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, P.O. Box 20, Tukholmankatu, 8 B 00014, Finland.; Folkhälsan Research Center, University of Helsinki, Helsinki, PO Box 2000014, Finland., Shea MK; Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA, 02111, USA., Houston DK; Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA., Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157, USA., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA., Lohman KK; Department of Biostatistical Sciences, Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA., Ferrucci L; Longitudinal Studies Section, Intramural Research Program of the National Institute on Aging, NIH, Baltimore, MD, 21225, USA., Peacock M; Department of Medicine, Indiana University, Endocrinology, 1120W Michigan Street, Indianapolis, IN, 46202-5124, USA., Gieger C; German Research Center for Environmental Health, Molecular Epidemiology, AME, Ingolstädter Landstr 1, D-85764, Neuherberg, Germany., Beekman M; Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands., Slagboom E; Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands., Deelen J; Molecular Epidemiology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Str. 9b, D-50931, Köln (Cologne), Germany., Heemst DV; Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Kleber ME; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer1, 68167, Mannheim, Germany., März W; Vth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer1, 68167, Mannheim, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Graz, Austria.; SYNLAB Holding Deutschland GmbH, Gubener Straße 39, 86156, Augsburg, Germany., de Boer IH; Division of Nephrology and Kidney Research Institute, University of Washington, 325 ninth Avenue, Washington, DC, 98104, USA., Wood AC; USDA/ARS Children's Nutrition Research Center, 1100 Bates Avenue, Houston, TX, 77071, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, 90502, USA., Rich SS; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA.; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, 22908, USA., Robinson-Cohen C; Division of Nephrology, Department of Medicine, Vanderbilt University Medical Center, 1161 21st Ave S., Nashville, TN, 37232, USA., den Heijer M; Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Jarvelin MR; Epidemiology and Biostatistics School of Public Health, Imperial College London, 156 Norfolk Place, St. Mary's Campus, London, UK W2 1PG, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Biocenter Oulu, University of Oulu, P.O. Box 5000, Aapistie 5A, FI-90014, Finland.; Unit of Primary Care, Oulu University Hospital, Kajaanintie 50, P.O. Box 20, FI-90220 Oulu, 90029 OYS, Finland., Cavadino A; Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK.; Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK., Joshi PK; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK., Wilson JF; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, the University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Hayward C; MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, the University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Lind L; Department of Medical Sciences, Uppsala University, 751 85, Uppsala, Sweden., Michaëlsson K; Department of Surgical Sciences, Uppsala University, Dag Hammarskjöldsv 14 B, Uppsala Science Park, 751 85, Uppsala, Sweden., Trompet S; Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.; Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands., Zillikens MC; Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Uitterlinden AG; Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.; Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Rivadeneira F; Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands.; Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Broer L; Erasmus MC Department of Internal Medicine, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Zgaga L; Department of Public Health and Primary Care, Institute of Population Health, Trinity College Dublin, University of Dublin, Dublin 24, D02 PN40, Ireland., Campbell H; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Theodoratou E; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK.; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Farrington SM; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Timofeeva M; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Dunlop MG; Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, EH4 2XU, UK., Valdes AM; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London, SE1 7EH, UK.; School of Medicine, University of Nottingham, City Hospital, Hucknall Rd, Nottingham, NG5 1PB, UK., Tikkanen E; FIMM-Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, P.O. Box 20, FI-00014, Finland., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.; Department of Clinical Chemistry, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland., Kähönen M; Department of Clinical Physiology, Tampere University Hospital, Tampere, 33521, Finland.; Department of Clinical Physiology, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, 33014, Finland., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20014, Finland., Mikkilä V; Science Adviser at Academy of Finland, Hakaniemenranta 6, PO Box 131, FI-00531, Helsinki, Finland., Ikram MA; Erasmus MC Department of Epidemiology, Postbus 2040, 3000CA, Rotterdam, The Netherlands., Sattar N; BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, University Avenue, Glasgow, G12 8QQ, UK., Jukema JW; Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, Netherlands.; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Forouhi NG; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK., Gundersen TE; Vitas AS, Gaustadaleen 21, N-0349, Oslo, Norway., Khaw KT; Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Butterworth AS; Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK., Danesh J; Department of Public Health & Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, CB10 1SA, UK., Spector T; The Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Campus, Westminster Bridge Road, London, SE1 7EH, UK., Wang TJ; Division of Cardiovascular Medicine, Vanderbilt Heart and Vascular Institute, 2220 Pierce Avenue 383 Preston Research Building, Nashville, TN, 37232-6300, USA., Hyppönen E; Population, Policy and Practice, University College London, Great Ormond Street, Institute of Child Health, London, WC1E 6BT, UK. elina.hypponen@unisa.edu.au.; Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, 5001, SA, Australia. elina.hypponen@unisa.edu.au., Kraft P; Program in Genetic Epidemiology and Statistical Genetics. Department of Epidemiology, Harvard T.H.Chan School of Public Health, 677 Huntington Avenue, Boston, 02115, MA, USA., Kiel DP; Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA. kiel@hsl.harvard.edu.; Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, 02115, USA. kiel@hsl.harvard.edu.; Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, MA, 02142, USA. kiel@hsl.harvard.edu.

Publikováno v: Nature communications [Nat Commun] 2018 Jan 17; Vol. 9 (1), pp. 260. Date of Electronic Publication: 2018 Jan 17.

Effects of intranasal insulin application on the hypothalamic BOLD response to glucose ingestion.

Autor: Opstal AMV; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands. a.m.van_opstal@lumc.nl., Akintola AA; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands., Elst MV; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands., Westendorp RG; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands.; Department of Public Health and Centre for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark., Pijl H; Department of Internal Medicine, Section Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands., Heemst DV; Department of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands., Grond JV; Department of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.

Publikováno v: Scientific reports [Sci Rep] 2017 Oct 17; Vol. 7 (1), pp. 13327. Date of Electronic Publication: 2017 Oct 17.