Výsledky vyhledávání - "Heemst, D. van"

Assessment of the bi-directional relationship between blood mitochondrial DNA copy number and type 2 diabetes mellitus

Autor: Wang, W.Y., Luo, J., Dijk, K.W. van, Hagg, S., Grassmann, F., Hart, L.M. 't, Heemst, D. van, Noordam, R.

Publikováno v: Diabetologia, 65, 1676-1686. SPRINGER

Aims/hypothesis Mitochondrial dysfunction, which can be approximated by blood mitochondrial DNA copy number (mtDNA-CN), has been implicated in the pathogenesis of type 2 diabetes mellitus. Thus far, however, insights from prospective cohort studies a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26510fba84bb47bc88ce9ea35ddeb72
https://hdl.handle.net/1887/3562831

Zobrazit plný text záznamu

Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism:A pooled analysis of two randomized controlled trials

Publikováno v: Lyko, C, Blum, M R, Abolhassani, N, Stuber, M J, Del Giovane, C, Feller, M, Moutzouri, E, Oberle, J, Jungo, K T, Collet, T-H, den Elzen, W P J, Poortvliet, R K E, Du Puy, R S, Dekkers, O M, Trompet, S, Jukema, J W, Aujesky, D, Quinn, T, Westendorp, R, Kearney, P M, Gussekloo, J, Van Heemst, D, Mooijaart, S P, Bauer, D C & Rodondi, N 2022, ' Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism : A pooled analysis of two randomized controlled trials ', Journal of Internal Medicine, vol. 292, no. 6, pp. 892-903 . https://doi.org/10.1111/joim.13544
Journal of Internal Medicine. WILEY
Journal of Internal Medicine
Lyko, Christina; Blum, Manuel R; Abolhassani, Nazanin; Stuber, Mirah J; Del Giovane, Cinzia; Feller, Martin; Moutzouri, Elisavet; Oberle, Jolanda; Jungo, Katharina T; Collet, Tinh-Hai; den Elzen, Wendy P J; Poortvliet, Rosalinde K E; Du Puy, Robert S; Dekkers, Olaf M; Trompet, Stella; Jukema, J Wouter; Aujesky, Drahomir; Quinn, Terry; Westendorp, Rudi; Kearney, Patricia M; ... (2022). Thyroid antibodies and levothyroxine effects in subclinical hypothyroidism: A pooled analysis of two randomized controlled trials. Journal of internal medicine, 292(6), pp. 892-903. Wiley 10.1111/joim.13544
Journal of internal medicine, 292(6), 892-903. Wiley-Blackwell
Journal of internal medicine, vol 292, iss 6

BACKGROUND Antithyroid antibodies increase the likelihood of developing overt hypothyroidism, but their clinical utility remains unclear. No large randomized controlled trial (RCT) has assessed whether older adults with subclinical hypothyroidism (SH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8cb511f7c195491958785950682d19
https://curis.ku.dk/portal/da/publications/thyroid-antibodies-and-levothyroxine-effects-in-subclinical-hypothyroidism(8fc056fc-b28c-48c4-a6a8-5f93f42a0b3b).html

Zobrazit plný text záznamu

Systemic inflammatory markers in relation to cognitive function and measures of brain atrophy: a Mendelian randomization study

Autor: Luo, J., Cessie, S. le, Blauw, G.J., Franceschi, C., Noordam, R., Heemst, D. van

Publikováno v: Geroscience, 44(4), 2259-2270. SPRINGER

Observational studies have implied associations between multiple cytokines and cognitive decline, anti-inflammatory drugs however did not yield any protective effects on cognitive decline. We aimed to assess the associations of systemic inflammation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c282d45af5f2bf0ad72fdfd9ab6422
https://pubmed.ncbi.nlm.nih.gov/35689786

Zobrazit plný text záznamu

Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression

Autor: Plaat, D. van der, Vonk, J.M., Terzikhan, N., Jong, K. de, Vries, M. de, Bastide-van Gemert, S. la, Diemen, C.C. van, Lahousse, L., Brusselle, G., Nedeljkovic, I., Amin, N., Kromhout, H., Vermeulen, R.C.H., Postma, D.S., Duijn, C.M. van, Boezen, H.M., Heijmans, B.T., Hoen, P.A.C.T., Meurs, J. van, Isaacs, A., Jansen, R., Franke, L., Boomsma, D.I., Pool, R., Dongen, J. van, Hottenga, J.J., Greevenbroek, M.M.J. van, Stehouwer, C.D.A., Kallen, C.J.H. van der, Schalkwijk, C.G., Wijmenga, C., Zhernakova, S., Tigchelaar, E.E., Slagboom, P.E., Beekman, M., Deelen, J., Heemst, D. van, Veldink, J.H., Berg, L.H. van den, Hofman, B.A., Uitterlinden, A.G., Jhamai, P.M., Verbiest, M., Suchiman, H.E.D., Verkerk, M., Breggen, R. van der, Rooij, J. van, Lakenberg, N., Mei, H., Iterson, M. van, Galen, M. van, Bot, J., Zhernakova, D.V., Hof, P.V., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M.J., Dijk, F. van, Arindrarto, W., Kielbasa, S.M., Swertz, M.A., Zwet, E.W. van, Hoen, P.B. 't, BIOS Consortium

Publikováno v: Human Molecular Genetics, 28(15), 2477. Oxford University Press
Human Molecular Genetics, 28(15), 2477-2485. Oxford University Press
Human Molecular Genetics
BIOS Consortium, Boomsma, D, Pool, R, van Dongen, J & Hottenga, J J 2019, ' Occupational exposure to gases/fumes and mineral dust affect DNA methylation levels of genes regulating expression ', Human molecular genetics, vol. 28, no. 15, pp. 2477-2485 . https://doi.org/10.1093/hmg/ddz067
Human Molecular Genetics, 28(15), 2477-2485
HUMAN MOLECULAR GENETICS
Human molecular genetics, 28(15), 2477-2485. Oxford University Press

Many workers are daily exposed to occupational agents like gases/fumes, mineral dust or biological dust, which could induce adverse health effects. Epigenetic mechanisms, such as DNA methylation, have been suggested to play a role. We therefore aimed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fcc6f6bac2bc4b27048a8dd8450bd4
https://cris.maastrichtuniversity.nl/en/publications/6a1f41cf-27f5-46f8-9d70-91af32912200

Zobrazit plný text záznamu

Genome-wide association study of circulating interleukin 6 levels identifies novel loci

Autor: Ahluwalia, T.S., Prins, B.P., Abdollahi, M., Armstrong, N.J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J.C., Mitchell, B.D., Geus, E. de, Delgado, G.E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J.P., Lu, C., Marioni, R.E., McLachlan, S., Milaneschi, Y., Nolte, I.M., Petrelis, A.M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppala, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C.M., Benjamin, E.J., Casas, J.P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M.F., Grallert, H., Hammarstedt, A., Harris, S.E., Homuth, G., Hottenga, J.J., Jalkanen, S., Jamshidi, Y., Jawahar, M.C., Jess, T., Kivimaki, M., Kleber, M.E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellstrom, D., Mooijaart, S.P., Muller-Nurasyid, M., Penninx, B., Revez, J.A., Rossing, P., Raikkonen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., St Pourcain, B., Timpson, N.J., Trollor, J., Dongen, J. van, Heemst, D. van, Visvikis-Siest, S., Vollenweider, P., Volker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R.W., Arnett, D.K., Baune, B.T., Boomsma, D.I., Chang, Y.P.C., Deary, I.J., Deloukas, P., Eriksson, J.G., Evans, D.M., Ferreira, M.A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S.E., Jukema, J.W., Koenig, W., Kumari, M., Kutalik, Z., Lawlor, D.A., Lehtimaki, T., Marz, W., Mather, K.A., Naitza, S., Nauck, M., Ohlsson, C., Price, J.F., Raitakari, O., Rice, K., Sachdev, P.S., Slagboom, E., Sorensen, T.I.A., Spector, T., Stacey, D., Stathopoulou, M.G., Tanaka, T., Wannamethee, S.G., Whincup, P., Rotter, J.I., Dehghan, A., Boerwinkle, E., Psaty, B.M., Snieder, H., Alizadeh, B.Z., CHARGE Inflammation Working Grp

Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease patho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10693::419097ac80cd2bb6100b73d0f2eefc60
https://hdl.handle.net/1887/3214139

Zobrazit plný text záznamu

Genome-wide association study of the postprandial triglyceride response yields common genetic variation in LIPC (hepatic lipase)

Autor: Ibi, D., Noordam, R., Klinken, J.B. van, Li-Gao, R.F., Mutsert, R. de, Trompet, S., Christen, T., Blauw, L.L., Heemst, D. van, Mook-Kanamori, D.O., Rosendaal, F.R., Jukema, J.W., Dolle, M.E.T., Rensen, P.C.N., Dijk, K.W. van

Background: The increase in serum triglyceride (TG) concentrations in response to a meal is considered a risk factor for cardiovascular disease. We aimed to elucidate the genetics of the postprandial TG response through genome-wide association studie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10693::db7d46a2e1bb3b5a424e6705c76249d9
https://hdl.handle.net/1887/3182376

Zobrazit plný text záznamu

A characterization of cis- and trans-heritability of RNA-Seq-based gene expression

Autor: Ouwens, K.G., Jansen, R., Nivard, M.G., Dongen, J. van, Frieser, M.J., Hottenga, J.J., Arindrarto, W., Claringbould, A., Iterson, M. van, Mei, H.L., Franke, L., Heijmans, B.T., Hoen, P.A.C. 't, Meurs, J. van, Brooks, A.I., Penninx, B.W.J.H., Boomsma, D.I., Isaacs, A., Pool, R., Greevenbroek, M.M.J. van, Stehouwer, C.D.A., Kallen, C.J.H. van der, Schalkwijk, C.G., Wijmenga, C., Zhernakova, S., Tigchelaar, E.F., Slagboom, P.E., Beekman, M., Deelen, J., Heemst, D. van, Veldink, J.H., Berg, L.H. van den, Duijn, C.M. van, Hofman, B.A., Uitterlinden, A.G., Jhamai, P.M., Verbiest, M., Suchiman, H.E.D., Verkerk, M., Breggen, R. van der, Rooij, J. van, Lakenberg, N., Galen, M. van, Bot, J., Zhernakova, D.V., van't Hof, P., Deelen, P., Nooren, I., Moed, M., Vermaat, M., Luijk, R., Bonder, M.J., Dijk, F. van, Kielbasa, S.M., Swertz, M.A., Zwet, E.W. van, Hoen, P.B. 't, BIOS Consortium

Publikováno v: Ouwens, K G, Jansen, R, Nivard, M G, van Dongen, J, Frieser, M J, Hottenga, J-J, Arindrarto, W, Claringbould, A, van Iterson, M, Mei, H, Franke, L, Heijmans, B T, A. C. ’t Hoen, P, van Meurs, J, Brooks, A I, Boomsma, D I, Penninx, B W J H & BIOS Consortium 2020, ' A characterization of cis-and trans-heritability of RNA-Seq-based gene expression ', European Journal of Human Genetics, vol. 28, no. 2, pp. 253-263 . https://doi.org/10.1038/s41431-019-0511-5
European Journal of Human Genetics, 28(2), 253-263. Nature Publishing Group
Ouwens, K G, Jansen, R, Nivard, M G, van Dongen, J, Hottenga, J-J, Penninx, B W J H, Boomsma, D I & BIOS Consortium 2020, ' A characterization of cis-and trans-heritability of RNA-Seq-based gene expression ', European Journal of Human Genetics, vol. 28, no. 2, pp. 253-263 . https://doi.org/10.1038/s41431-019-0511-5
European Journal of Human Genetics, 28, 253-263
Eur J Hum Genet
European Journal of Human Genetics, 28, 2, pp. 253-263
European Journal of Human Genetics, 28(2), 253-263. NATURE PUBLISHING GROUP

Insights into individual differences in gene expression and its heritability (h2) can help in understanding pathways from DNA to phenotype. We estimated the heritability of gene expression of 52,844 genes measured in whole blood in the largest twin R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b724edc5b8ecf280bc310da19b2529ee
https://research.vumc.nl/en/publications/029df33c-d648-47cb-b258-60c60eed93d1

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání