Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Heekwang Park"'
Autor:
Bumki Kim, Seongrim Byeon, Hendrik Luesch, Heekwang Park, Patrick E. Serrano, Soyoung Ryu, Qi-Yin Chen, Yanxia Liu, Jason C. Kwan, Sabrina L. Zeller, Lilibeth A. Salvador, Jiyong Hong
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3728-3731
Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor. The majority of largazole analogues to date have modified the thiazole-thiazoline and the warhead moiety. In order to elucidate class I-specific structure-activity relation
Autor:
Bumki Kim, Jiyong Hong, Lilibeth A. Salvador, Yanxia Liu, Sabrina L. Zeller, Fatma H. Al-Awadhi, Qi-Yin Chen, Hendrik Luesch, Heekwang Park
Publikováno v:
ACS Medicinal Chemistry Letters. 5:905-910
Largazole is a potent and class I-selective histone deacetylase (HDAC) inhibitor purified from marine cyanobacteria and was demonstrated to possess antitumor activity. Largazole employs a unique prodrug strategy, via a thioester moiety, to liberate t
Autor:
Pengyu Ren, Yue Shi, Shreya Mitra, Kiyoun Lee, Chun Chia Tseng, Jiney Jose, Kevin N. Dalby, Chunli Yan, Juliana M. Taliaferro, Tamer S. Kaoud, Heekwang Park, Jiyong Hong
Publikováno v:
ACS Chemical Biology. 7:1873-1883
Recently, in a virtual screening strategy to identify new compounds targeting the D-recruitment site (DRS) of the c-Jun N-terminal kinases (JNKs), we identified the natural product (-)-zuonin A. Here we report the asymmetric synthesis of (-)-zuonin A
Publikováno v:
Organic Letters. 13:3742-3745
An efficient formal synthesis of SCH 351448 was accomplished through the tandem cross-metathesis (CM)/oxa-Michael, the 1,4-syn aldol, the tandem oxidation/oxa-Michael, and the Suzuki coupling reaction.
Autor:
Chunli Yan, Jiyong Hong, Rachel M. Sammons, Tamer S. Kaoud, Shreya Mitra, Ashwini K. Devkota, Chun Chia Tseng, Yue Shi, Juliana M. Taliaferro, Jiney Jose, Heekwang Park, Kevin N. Dalby, Pengyu Ren, Maidina Tuohetahuntila, Jihyun Park
Publikováno v:
ACS medicinal chemistry letters. 3(9)
The JNK-JIP1 interaction represents an attractive target for the selective inhibition of JNK-mediated signaling. We report a virtual screening (VS) workflow, based on a combination of three-dimensional shape and electrostatic similarity to discover n
Publikováno v:
Organic letters. 13(21)
The total synthesis of psymberin was achieved employing a readily available chiral epoxide to prepare two of the three subunits in the natural product. The key reaction was a highly stereoselective organocatalytic oxa-conjugate addition reaction of
Publikováno v:
Organic Letters; Nov2011, Vol. 13 Issue 21, p5816-5819, 4p