Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Heehwa G. Son"'
Autor:
Jong Ho Park, Mahsa Mortaja, Heehwa G. Son, Xutu Zhao, Lauren M. Sloat, Marjan Azin, Jun Wang, Michael R. Collier, Krishna S. Tummala, Anna Mandinova, Nabeel Bardeesy, Yevgeniy R. Semenov, Mari Mino-Kenudson, Shadmehr Demehri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Chronic inflammation is a major cause of cancer worldwide. Interleukin 33 (IL-33) is a critical initiator of cancer-prone chronic inflammation; however, its induction mechanism by environmental causes of chronic inflammation is unknown. Here
Externí odkaz:
https://doaj.org/article/e2b006d3a3b94b3d96580a3db87ec074
Autor:
Luke H. Johnson, Heehwa G. Son, Dat Thinh Ha, John D. Strickley, Joongho Joh, Shadmehr Demehri
Publikováno v:
JID Innovations, Vol 3, Iss 2, Pp 100163- (2023)
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer, with increased incidence in immunosuppressed patients. β-Human papillomavirus has been proposed as a contributor to cSCC risk partly on the basis of increased β-human papill
Externí odkaz:
https://doaj.org/article/9990bd65a89343b0a082d1b0498ad838
Autor:
Hae-Eun H. Park, Wooseon Hwang, Seokjin Ham, Eunah Kim, Ozlem Altintas, Sangsoon Park, Heehwa G. Son, Yujin Lee, Dongyeop Lee, Won Do Heo, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mutations in daf-2/insulin/IGF-1 receptor impair the growth and reproduction of C. elegans but conversely enhance immunity and lifespan. Here, the authors show that a missense mutation in the gene retains the effects on lifespan and immunity and impr
Externí odkaz:
https://doaj.org/article/4be13eaae3814a74aa5a5c7e9ff9e0a6
Publikováno v:
Translational Medicine of Aging, Vol 1, Iss , Pp 24-31 (2017)
RNA helicases are members of a large family of enzymes that function in unwinding RNA duplexes and modulating interactions between RNAs and proteins. RNA helicases participate in numerous cellular processes, including transcription, translation, mRNA
Externí odkaz:
https://doaj.org/article/714ad549a104438f8491de8b804337d3
Autor:
Hoe-Yune Jung, Dongyeop Lee, Hye Guk Ryu, Bo-Hwa Choi, Younghoon Go, Namgyu Lee, Dohyun Lee, Heehwa G. Son, Jongsu Jeon, Seong-Hoon Kim, Jong Hyuk Yoon, Seon-Min Park, Seung-Jae V. Lee, In-Kyu Lee, Kwan Yong Choi, Sung Ho Ryu, Kazunari Nohara, Seung-Hee Yoo, Zheng Chen, Kyong-Tai Kim
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Robust mitochondrial respiration provides energy to support physical performance and physiological well-being, whereas mitochondrial malfunction is associated with various pathologies and reduced longevity. In the current study, we tested wh
Externí odkaz:
https://doaj.org/article/10201d00788242438ead92d92999e6dd
Autor:
Heehwa G. Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A. An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N. Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T. Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevit
Externí odkaz:
https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc7
Autor:
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee
Publikováno v:
F1000Research, Vol 6 (2017)
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditi
Externí odkaz:
https://doaj.org/article/d778e6352493489fae62592a3b9798f3
Autor:
Sangsoon Park, Yoonji Jung, Seon Woo A. An, Heehwa G. Son, Wooseon Hwang, Dongyeop Lee, Murat Artan, Hae-Eun H. Park, Dae-Eun Jeong, Yujin Lee, Seung-Jae V. Lee
Publikováno v:
F1000Research, Vol 6 (2017)
Background: α-arrestins are a family of proteins that are implicated in multiple biological processes, including metabolism and receptor desensitization. Methods: Here, we sought to examine the roles of α-arrestins in the longevity of Caenorhabditi
Externí odkaz:
https://doaj.org/article/0e2ea24daffb419282d20c588166ab9d
Autor:
Tatsuya Hasegawa, Tomonori Oka, Heehwa G. Son, Valeria S. Oliver-García, Marjan Azin, Thomas M. Eisenhaure, David J. Lieb, Nir Hacohen, Shadmehr Demehri
Senescent cell accumulation has been implicated in the pathogenesis of aging-associated diseases including cancer. The mechanism that prevents the accumulation of senescent cells in aging human organs is unclear. Here, we demonstrate that a virus-imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90795758e1b727f52e2d7b48177a6069
https://doi.org/10.1101/2023.03.06.531282
https://doi.org/10.1101/2023.03.06.531282
Autor:
Yujin Lee, Ozlem Altintas, Seokjin Ham, Eunah Kim, Seung-Jae Lee, Won Do Heo, Hae-Eun H. Park, Wooseon Hwang, Dongyeop Lee, Sangsoon Park, Heehwa G. Son
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Insulin/IGF-1 signaling (IIS) regulates various physiological aspects in numerous species. In Caenorhabditis elegans, mutations in the daf-2/insulin/IGF-1 receptor dramatically increase lifespan and immunity, but generally impair motility, growth, an