Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Heehong Hwang"'
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Pathologic α-synuclein (α-syn) spreads from cell-to-cell, in part, through binding to the lymphocyte-activation gene 3 (Lag3). Here we report that amyloid β precursor-like protein 1 (Aplp1) interacts with Lag3 that facilitates the binding
Externí odkaz:
https://doaj.org/article/a51c0a5470e944f6b5b546f3fa48e34f
Autor:
Xiaobo Mao, Hao Gu, Donghoon Kim, Yasuyoshi Kimura, Ning Wang, Enquan Xu, Ramhari Kumbhar, Xiaotian Ming, Haibo Wang, Chan Chen, Shengnan Zhang, Chunyu Jia, Yuqing Liu, Hetao Bian, Senthilkumar S. Karuppagounder, Fatih Akkentli, Qi Chen, Longgang Jia, Heehong Hwang, Su Hyun Lee, Xiyu Ke, Michael Chang, Amanda Li, Jun Yang, Cyrus Rastegar, Manjari Sriparna, Preston Ge, Saurav Brahmachari, Sangjune Kim, Shu Zhang, Yasushi Shimoda, Martina Saar, Haiqing Liu, Sin Ho Kweon, Mingyao Ying, Creg J. Workman, Dario A. A. Vignali, Ulrike C. Muller, Cong Liu, Han Seok Ko, Valina L. Dawson, Ted M. Dawson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/59a521d03e984273bb3d708b36d570e9
Autor:
Donghoon Kim, Heehong Hwang, Seulah Choi, Sang Ho Kwon, Suhyun Lee, Jae Hong Park, SangMin Kim, Han Seok Ko
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Heterozygous mutations in glucocerebrosidase 1 (GBA1) are a major genetic risk factor for Parkinson’s disease and Dementia with Lewy bodies. Mutations in GBA1 leads to GBA1 enzyme deficiency, and GBA1-associated parkinsonism has an earlier
Externí odkaz:
https://doaj.org/article/894ee81733374e69a93f6fd626222b7f
Autor:
Seulah Choi, Donghoon Kim, Tae-In Kam, Seungpil Yun, Sangjune Kim, Hyejin Park, Heehong Hwang, Olga Pletnikova, Juan C Troncoso, Valina L Dawson, Ted M Dawson, Han Seok Ko
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143854 (2015)
Glucocerebrosidase (GCase) functions as a lysosomal enzyme and its mutations are known to be related to many neurodegenerative diseases, including Gaucher's disease (GD), Parkinson's disease (PD), and Dementia with Lewy Bodies (DLB). However, there i
Externí odkaz:
https://doaj.org/article/51fa112d70ee463591d8203cbdcdd344
Publikováno v:
Molecular Pain
Although microglia activation plays an important role in the development of nerve injury-induced neuropathic pain, the molecular mechanisms of spinal cord microglia activation in nerve injury are not completely understood. Recently, two injured senso
Autor:
Boomin Choi, Junyoung Oh, Seungmin Baik, Yelina Manandhar, Min Soh, Kwangsoo Shin, Sagang Koo, Taeghwan Hyeon, Sung Joong Lee, Dokyoon Kim, Sang Ihn Han, Hyek Jin Kwon, Heehong Hwang, Giho Ko
Publikováno v:
Nanoscale. 11:19437-19447
Neuropathic pain is a chronic and pathological pain caused by injury or dysfunction in the nervous system. Pro-inflammatory microglial activation with aberrant reactive oxygen species (ROS) generation in the spinal cord plays a critical role in the d
Autor:
Seung-Hwan Kwon, Wei Yan, Min Seong Kim, Kwangsoo Kim, Senthilkumar S. Karuppagounder, Ted M. Dawson, Dong-Hoon Kim, Heehong Hwang, Sangjune Kim, Xiaobo Mao, Valina L. Dawson, Bo Am Seo, Je Min Yoo, Sang Ho Kwon, Seulah Choi, Sung Ung Kang, Javier Redding-Ochoa, Saebom Lee, Shi Xun Ma, Bong Gu Kang, Sin Ho Kweon, Olga Pletnikova, Tae In Kam, Juan C. Troncoso, Hu Wang, Hyejin Park, Gabsang Lee, Yong-Shi Li, Sheng-Han Kuo, Han Seok Ko
Publikováno v:
Neuron
Summary Impairment in glucocerebrosidase (GCase) is strongly associated with the development of Parkinson’s disease (PD), yet the regulators responsible for its impairment remain elusive. In this paper, we identify the E3 ligase Thyroid Hormone Rec
Autor:
Seokmin Shin, Yong Joo Park, Je Min Yoo, Young-Ho Lee, Byung Hee Hong, Seung Pil Yun, Seulah Choi, Suhyun Lee, Junghee Lee, Saebom Lee, Han Seok Ko, Seung R. Paik, Misaki Kinoshita, Sung Joong Lee, Seulki Lee, MinJun Lee, Dong-Hoon Kim, Sangjune Kim, Heehong Hwang, Seung-Hwan Kwon, Myung Jin Park, Sang Ho Kwon
While the emerging evidence indicates that the pathogenesis of Parkinson's disease (PD) is strongly correlated to the accumulation of alpha-synuclein ({\alpha}-syn) aggregates, there has been no clinical success in anti-aggregation agents for the dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e3cb685c6b877f2a03269fdca103c08
https://europepmc.org/articles/PMC6351226/
https://europepmc.org/articles/PMC6351226/
Autor:
Suhyun Lee, Jae Hong Park, Dong-Hoon Kim, Sang Ho Kwon, Han Seok Ko, Heehong Hwang, SangMin Kim, Seulah Choi
Publikováno v:
Acta Neuropathologica Communications
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Heterozygous mutations in glucocerebrosidase 1 (GBA1) are a major genetic risk factor for Parkinson’s disease and Dementia with Lewy bodies. Mutations in GBA1 leads to GBA1 enzyme deficiency, and GBA1-associated parkinsonism has an earlier age of o
Publikováno v:
IBRO Reports. 6:S370