Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Heegyum Moon"'
Autor:
Heegyum Moon, Ha Na Jang, Yongchao Liu, Namjeong Choi, Jagyeong Oh, Jiyeon Ha, Xuexiu Zheng, Haihong Shen
Publikováno v:
Cells, Vol 8, Iss 7, p 696 (2019)
Here we show that the serine/arginine rich splicing factor 2 (SRSF2) promotes cryptic 3′ splice-site (3′AG′) usage during cassette exon exclusion in survival of motor neuron (SMN2) minigenes. Deletion of the 3′AG′ (3′AG′1), its associat
Externí odkaz:
https://doaj.org/article/05f3df84298b42338160bd6a0eb23620
Autor:
Sunghee Cho, Heegyum Moon, Tiing Jen Loh, Hyun Kyung Oh, Hey-Ran Kim, Myung-Geun Shin, D. Joshua Liao, Jianhua Zhou, Xuexiu Zheng, Haihong Shen
Publikováno v:
The Scientific World Journal, Vol 2014 (2014)
Spinal muscular atrophy (SMA) is a human genetic disease which occurs because of the deletion or mutation of SMN1 gene. SMN1 gene encodes the SMN protein which plays a key role in spliceosome assembly. Although human patients contain SMN2, a duplicat
Externí odkaz:
https://doaj.org/article/5569434416a9446aafce03d7631d558f
Autor:
Hyeonho Jeon, Ji Sun Hwang, Soosung Kang, Eunsun Park, Sun Choi, Ki Bum Hong, Hayoung Hwang, Jongmi Park, Heegyum Moon, Sun Joo Lee, Seunghee Han
Publikováno v:
Journal of Medicinal Chemistry. 64:958-979
Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ed7d00233d7114b18f7d0230a0a1d6e
https://doi.org/10.1021/acs.jmedchem.0c01026
https://doi.org/10.1021/acs.jmedchem.0c01026
Autor:
Chulhwan Kwak, Cheolhun Park, Minjeong Ko, Chun Young Im, Heegyum Moon, Young-Hoon Park, So Young Kim, Seungyeon Lee, Myeong-Gyun Kang, Ho Jeong Kwon, Eunmi Hong, Jeong Kon Seo, Hyun-Woo Rhee
Publikováno v:
Cell Chemical Biology. 29:1739-1753.e6
Direct identification of the proteins targeted by small molecules can provide clues for disease diagnosis, prevention, and drug development. Despite concentrated attempts, there are still technical limitations associated with the elucidation of direc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ce35b067f9dbb0a50ba85fad1890e8
https://doi.org/10.1016/j.chembiol.2022.10.001
https://doi.org/10.1016/j.chembiol.2022.10.001
Autor:
Jagyeong Oh, Xuexiu Zheng, Haihong Shen, Namjeong Choi, Heegyum Moon, Ha Na Jang, Yongchao Liu, Hyeon Ho Kim, Jiyeon Ha
Publikováno v:
BMB Reports
The Ron proto-oncogene is a human receptor for macrophage-stimulating protein (MSP). The exclusion of exon 11 in alternative splicing generates ΔRON protein that is constitutively activated. Heterogenous ribonucleaoprotein (hnRNP) C1/C2 is one of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a89e6f2af605d81c30ced99e23d45e32
https://doi.org/10.5483/bmbrep.2019.52.11.080
https://doi.org/10.5483/bmbrep.2019.52.11.080
Autor:
Eunsun, Park, Sun Joo, Lee, Heegyum, Moon, Jongmi, Park, Hyeonho, Jeon, Ji Sun, Hwang, Hayoung, Hwang, Ki Bum, Hong, Seung-Hee, Han, Sun, Choi, Soosung, Kang
Publikováno v:
Journal of medicinal chemistry. 64(2)
Janus kinase 1 (JAK1) plays a key role in most cytokine-mediated inflammatory and autoimmune responses through JAK/STAT signaling; thus, JAK1 inhibition is a promising therapeutic strategy for several diseases. Analysis of the binding modes of curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ebfb5496d50c96d277ce06804bc8110
https://pubmed.ncbi.nlm.nih.gov/33428419
https://pubmed.ncbi.nlm.nih.gov/33428419
Autor:
HEEGYUM MOON1, XUEXIU ZHENG1, TIING JEN LOH1, HA NA JANG1, YONGCHAO LIU1, DA-WOON JUNG1, WILLIAMS, DARREN R.1, HAIHONG SHEN1 haihongshen@gist.ac.kr
Publikováno v:
Oncology Letters. Mar2017, Vol. 13 Issue 3, p1944-1948. 5p.
Autor:
Namjeong Choi, Ha Na Jang, Heegyum Moon, Xuexiu Zheng, Jiyeon Ha, Michael B. Ye, Dong-Eun Kim, Tiing Jen Loh, Jianhua Zhou, Yongchao Liu, Haihong Shen, Sungchan Cho, Sunghee Cho, Jagyeong Oh
Publikováno v:
BMB REPORTS(50): 8
BMB Reports
BMB Reports
SRSF2, a Serine-Arginine rich (SR) protein, is a splicing activator that mediates exon inclusion and exclusion events equally well. Here we show SRSF2 directly suppresses intron splicing to suppress cassette exon inclusion in SMN premRNA. Through a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840c6dc34613434c2e716a793ae673aa
https://doi.org/10.5483/bmbrep.2017.50.8.103
https://doi.org/10.5483/bmbrep.2017.50.8.103
Autor:
Jianhua Zhou, Namjeong Choi, Heegyum Moon, Haihong Shen, Xuexiu Zheng, Tiing Jen Loh, Yongchao Liu, Ha Na Jang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1860:363-373
Selection of 5' splice-sites (5'SS) in alternative splicing plays an important role in gene regulation. Although regulatory mechanisms of heterogeneous nuclear ribonucleoprotein L (hnRNP L), a well-known splicing regulatory protein, have been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d1769087bb4ec4e22580ce68aaada
https://doi.org/10.1016/j.bbagrm.2017.01.010
https://doi.org/10.1016/j.bbagrm.2017.01.010
Autor:
Xuexiu Zheng, Darren R. Williams, Heegyum Moon, Tiing Jen Loh, Yongchao Liu, Ha Na Jang, Da-Woon Jung, Haihong Shen
Publikováno v:
Oncology Letters. 13:1944-1948
The récepteur d'origine nantais (RON) gene is a proto-oncogene that is responsible for encoding the human macrophage-stimulating protein (MSP) 1 receptor. MSP activation induces RON-mediated cell dissociation, migration and matrix invasion. Isoforms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a486e736b680f40a100e7ebd1f48e6d
https://doi.org/10.3892/ol.2017.5627
https://doi.org/10.3892/ol.2017.5627