Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Heechul Jun"'
Autor:
Tsukasa Funane, Heechul Jun, Stephanie Sutoko, Takaomi C. Saido, Akihiko Kandori, Kei M. Igarashi
Publikováno v:
Frontiers in Systems Neuroscience, Vol 16 (2022)
Clinical evidence suggests that the entorhinal cortex is a primary brain area triggering memory impairments in Alzheimer’s disease (AD), but the underlying brain circuit mechanisms remain largely unclear. In healthy brains, sharp-wave ripples (SWRs
Externí odkaz:
https://doaj.org/article/ef436e5f053a451fa91ad306caf0549d
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100759- (2021)
Summary: Hippocampal place cells and entorhinal grid cells exhibit distinct spike patterns in different environments called “remapping,” and we have recently shown that remapping of place cells becomes disrupted in a mouse model of Alzheimer's di
Externí odkaz:
https://doaj.org/article/c7d383df77af4f3685e69b69fad4338f
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
Adult neurogenesis, the process of generating new neurons from neural stem cells, plays significant roles in synaptic plasticity, memory, and mood regulation. In the mammalian brain, it continues to occur well into adulthood in discrete regions, name
Externí odkaz:
https://doaj.org/article/ae561a4c28b34ceda353906f46bd7dc2
Autor:
Kaori Shiraiwa, Sandra Yungblut, Shogo Soma, Tatsuki Nakagawa, Heechul Jun, Koshi Murata, Meiko Hagihara, Rodrigo Romo, Ananya Dasgupta, Jasmine Chavez, Tomoaki Nakazono, Jason Y. Lee, Jiayun L. Xie, Kei M. Igarashi
Publikováno v:
Nature
Mounting evidence shows that dopamine in the striatum is critically involved in reward-based reinforcement learning1,2. However, it remains unclear how dopamine reward signals influence the entorhinal–hippocampal circuit, another brain network that
Publikováno v:
Curr Opin Neurobiol
Learning leads to a neuronal representation of acquired knowledge. This idea of knowledge representation was traditionally developed as a “cognitive map” of spatial memory represented in the hippocampus. The framework of cognitive mapping has bee
Publikováno v:
IEEE Access, Vol 12, Pp 120612-120623 (2024)
Multiobjective evolutionary algorithms are highly effective in solving multiobjective optimization problems (MOPs). The selection strategy, involving mating and environmental selection, is crucial in shaping these algorithms. However, when applied to
Externí odkaz:
https://doaj.org/article/645e5a042a2a467aa792125aaafb01f0
Publikováno v:
IEEE Access, Vol 12, Pp 49275-49290 (2024)
In recent decades, multi-objective evolutionary algorithms (MOEAs) have been evaluated on artificial test problems with unrealistic characteristics, leading to uncertain conclusions about their efficacy in real-world applications. To address this iss
Externí odkaz:
https://doaj.org/article/0ae8b832d1a243bbb72f6307cbee8a22
Publikováno v:
Neuron. 107(6)
Patients with Alzheimer's disease (AD) suffer from spatial memory impairment and wandering behavior, but the brain circuit mechanisms causing such symptoms remain largely unclear. In healthy brains, spatially tuned hippocampal place cells and entorhi
Patients with Alzheimer’s disease (AD) frequently suffer from spatial memory impairment and wandering behavior, but brain circuits causing such symptoms remain largely unclear. In healthy brains, spatially-tuned hippocampal place cells and entorhin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c786118d400bdba20d723ff0f762a02f
Publikováno v:
Neuroscience Research. 129:40-46
Gamma oscillations that occur within the entorhinal cortex-hippocampal circuitry play important roles in the formation and retrieval of memory in healthy brains. Recent studies report that gamma oscillations are impaired in the entorhinal-hippocampal