Zobrazeno 1 - 10
of 308
pro vyhledávání: '"Hee-Yeon Cho"'
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 4, Pp 1497-1512 (2022)
Mesenchymal stem cells (MSCs) have been widely applied to the regeneration of damaged tissue and the modulation of immune response. The purity of MSC preparation and the delivery of MSCs to a target region are critical factors for success in therapeu
Externí odkaz:
https://doaj.org/article/59253debba534a46abfd3b23e3f2f2c7
Autor:
Radu O Minea, Tuan Cao Duc, Stephen D Swenson, Hee-Yeon Cho, Mickey Huang, Hannah Hartman, Florence M Hofman, Axel H Schönthal, Thomas C Chen
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
The prognosis for patients with glioblastoma (GB) remains grim. Concurrent temozolomide (TMZ) radiation-the cornerstone of glioma control-extends the overall median survival of GB patients by only a few months over radiotherapy alone. While these sur
Externí odkaz:
https://doaj.org/article/06b1342876a949aa97d7626567027847
Autor:
Taeyoung Koo, Sung Wook Park, Dong Hyun Jo, Daesik Kim, Jin Hyoung Kim, Hee-Yeon Cho, Jeungeun Kim, Jeong Hun Kim, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
The CRISPR endonuclease LbCpf1 is reported to have greater efficiency and specificity than Cas9. Here, the authors use LbCpf1 to target the angiogenesis-related genes VEGF and HIF1a, and show that delivery of the nuclease using AAV9 is effective in m
Externí odkaz:
https://doaj.org/article/25757b2b16cb4f498da30b72b2a47f63
Autor:
Eunji Kim, Taeyoung Koo, Sung Wook Park, Daesik Kim, Kyoungmi Kim, Hee-Yeon Cho, Dong Woo Song, Kyu Jun Lee, Min Hee Jung, Seokjoong Kim, Jin Hyoung Kim, Jeong Hun Kim, Jin-Soo Kim
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The amount of genetic material that can be packaged in AAV vectors used for genome editing is limited. Here the authors show that the smallest known Cas9 orthologue, cjCas9, can be packaged in a single AAV vector along with sgRNA and a marker gene, a
Externí odkaz:
https://doaj.org/article/979620e5b6d94aa09d84d0a42e5ed2a6
Autor:
Thomas C. Chen, Nymph Chan, Shirin Labib, Jiali Yu, Hee-Yeon Cho, Florence M. Hofman, Axel H. Schönthal
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 1, p 277 (2018)
Despite the introduction of new therapies for multiple myeloma (MM), many patients are still dying from this disease and novel treatments are urgently needed. We have designed a novel hybrid molecule, called NEO214, that was generated by covalent con
Externí odkaz:
https://doaj.org/article/8d56f9ad78e24b72a1a1309037d3abc2
Autor:
Yun-Sik Choi, Boyoung Lee, Hee-Yeon Cho, Iza B. Reyes, Xin-An Pu, Takaomi C. Saido, Kari R. Hoyt, Karl Obrietan
Publikováno v:
Neurobiology of Disease, Vol 36, Iss 2, Pp 259-268 (2009)
Evidence of dysregulation of the CREB/CRE transcriptional pathway in animal models of Huntington's disease (HD) suggests that strategies designed to augment CRE-mediated transcription may be of therapeutic value. Here, we investigated the consequence
Externí odkaz:
https://doaj.org/article/b3db19af17c74350bddacfb28c78c3a7
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 13, p 6877 (2022)
In patients with type 1 diabetes (T1D), compromised pancreatic β-cell functions are compensated through daily insulin injections or the transplantation of pancreatic tissue or islet cells. However, both approaches are associated with specific challe
Externí odkaz:
https://doaj.org/article/2052e1ee9be64480975bfd1e076fb58b
Autor:
Weijun Wang, Haiping He, Shan Zeng, Hee-Yeon Cho, Radu O. Minea, Steven D. Swenson, Long Zheng, Alan L. Epstein, Apostolos Stathopoulos, Ligang Chen, Axel H. Schönthal, Thomas C. Chen
Publikováno v:
Journal of Neurosurgery. :1-9
OBJECTIVE Immune checkpoint-inhibitory therapeutic antibodies have shown striking activity against several types of cancers but are less effective against brain-localized malignancies, in part due to the protective effect of the blood-brain barrier (
Autor:
Hea Min Jang, Hee Sun Baek, Jung-Eun Kim, Ju Young Kim, Yeon Hee Lee, Hee Yeon Cho, Yon Ho Choe, Ben Kang, Byung-Ho Choe, Bong Seok Choi, Min Hyun Cho
Publikováno v:
Korean Journal of Pediatrics, Vol 61, Iss 10, Pp 327-331 (2018)
Purpose The incidence of inflammatory bowel disease (IBD) is rapidly increasing, and several reports have described the renal complications of IBD. We sought to evaluate the clinical manifestations of renal complications in children with IBD in order
Externí odkaz:
https://doaj.org/article/ad04cbf159814016bd1132f868688cfc
Autor:
Thomas C. Chen, Florence M. Hofman, Axel H. Schönthal, Nagore I. Marín-Ramos, Mengting Ou, Rochelle A. Fayngor, Stephen D. Swenson, Weijun Wang, Thu Zan Thein, Hee-Yeon Cho
Human astrocytes produce TRAIL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716e3cd8913f65a783ccf58f33c2b19f
https://doi.org/10.1158/1535-7163.22510404.v1
https://doi.org/10.1158/1535-7163.22510404.v1