Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Hee-Sae Park"'
Autor:
Cho-Long Kim, Su-Bin Lim, Sue-Hee Choi, Dong Hyun Kim, Ye Eun Sim, Eun-Hye Jo, Keeeun Kim, Keesook Lee, Hee-Sae Park, Su Bin Lim, Li-Jung Kang, Han-Sol Jeong, Youngsoo Lee, Carsten G. Hansen, Jung-Soon Mo
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The Hippo pathway’s main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP’s phosphorylation by core upstream components of the Hippo pathway, such as mammalian Ste20 kina
Externí odkaz:
https://doaj.org/article/34d72262de544b49bea4480b357ee804
Autor:
Seul Gi Lee, Jongbeom Chae, Seon Min Woo, Seung Un Seo, Ha-Jeong Kim, Sang-Yeob Kim, David D. Schlaepfer, In-San Kim, Hee-Sae Park, Taeg Kyu Kwon, Ju-Ock Nam
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 3, Pp 520-531 (2023)
Fat metabolism: protecting against obesity-related metabolic disorders Studying a protein called TGFBI, which regulates adipose expansion, may help the development of new approaches to protect against obesity and related metabolic disorders such as t
Externí odkaz:
https://doaj.org/article/553128a2c59e4034b9f3735a4d3e3a37
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244553 (2020)
Leydig cells represent the steroidogenic lineage of mammalian testis, which produces testosterone. Genetic evidence indicates the requirement of Notch signaling in maintaining a balance between differentiated Leydig cells and their progenitors during
Externí odkaz:
https://doaj.org/article/b60fe9a2b79740708bd015aba55001f3
Autor:
Taejeong Ha, Kyeong Hwan Moon, Le Dai, Jun Hatakeyama, Keejung Yoon, Hee-Sae Park, Young-Yoon Kong, Kenji Shimamura, Jin Woo Kim
Publikováno v:
Cell Reports, Vol 19, Iss 2, Pp 351-363 (2017)
Summary: Notch signaling in neural progenitor cell is triggered by ligands expressed in adjacent cells. To identify the sources of active Notch ligands in the mouse retina, we negatively regulated Notch ligand activity in various neighbors of retinal
Externí odkaz:
https://doaj.org/article/3639000f42a04fbe8f6b1290c72c94c5
Autor:
Jung-Soon Mo, Ji-Hye Yoon, Ji-Ae Hong, Mi-Yeon Kim, Eun-Jung Ann, Ji-Seon Ahn, Su-Man Kim, Hyeong-Jin Baek, Florian Lang, Eui-Ju Choi, Hee-Sae Park
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37111 (2012)
The gamma-secretase complex is involved in the intramembranous proteolysis of a variety of substrates, including the amyloid precursor protein and the Notch receptor. Nicastrin (NCT) is an essential component of the gamma-secretase complex and functi
Externí odkaz:
https://doaj.org/article/f0e44069278641f68803c0c9b434e454
Publikováno v:
BMB Reports. 56:265-274
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ddf0886cc9392323a907e2cacdd4667
https://doi.org/10.5483/bmbrep.2023-0037
https://doi.org/10.5483/bmbrep.2023-0037
Autor:
Hee-Sae Park, Keesook Lee, Adolfo A. Ferrando, Cheol Yong Choi, Ji Shin Lee, Kyung-Hee Chun, Dong Wook Choi, Hyeok-Gu Kang, Hyun-Woo Lee, Hye-Jin Lee, Eun-Hye Jo, Ji-Seon Ahn, Ji-Hye Yoon, Mi-Yeon Kim, Eun-Jung Ann
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c3eb75a03e51c66ae87702bb66b4e6
https://doi.org/10.1158/0008-5472.22411076.v1
https://doi.org/10.1158/0008-5472.22411076.v1
Autor:
Hee-Sae Park, Keesook Lee, Adolfo A. Ferrando, Cheol Yong Choi, Ji Shin Lee, Kyung-Hee Chun, Dong Wook Choi, Hyeok-Gu Kang, Hyun-Woo Lee, Hye-Jin Lee, Eun-Hye Jo, Ji-Seon Ahn, Ji-Hye Yoon, Mi-Yeon Kim, Eun-Jung Ann
Supplementary Figure 1: ADR suppresses Notch1 signaling. Supplementary Figure 2: ADR inhibits the transcriptional activity of Notch1 by inducing HIPK2. Supplementary Figure 3: HIPK2 regulates the Notch1-IC protein stability through proteasomal degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac027f72d8a7059dd4bfb83cd7b67d0d
https://doi.org/10.1158/0008-5472.22411067.v1
https://doi.org/10.1158/0008-5472.22411067.v1
Autor:
Hee-Sae Park, Keesook Lee, Adolfo A. Ferrando, Cheol Yong Choi, Ji Shin Lee, Kyung-Hee Chun, Dong Wook Choi, Hyeok-Gu Kang, Hyun-Woo Lee, Hye-Jin Lee, Eun-Hye Jo, Ji-Seon Ahn, Ji-Hye Yoon, Mi-Yeon Kim, Eun-Jung Ann
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4bfd9b8154f67ab51c51e444a5b8071
https://doi.org/10.1158/0008-5472.22411073
https://doi.org/10.1158/0008-5472.22411073
Autor:
Hee-Sae Park, Keesook Lee, Adolfo A. Ferrando, Cheol Yong Choi, Ji Shin Lee, Kyung-Hee Chun, Dong Wook Choi, Hyeok-Gu Kang, Hyun-Woo Lee, Hye-Jin Lee, Eun-Hye Jo, Ji-Seon Ahn, Ji-Hye Yoon, Mi-Yeon Kim, Eun-Jung Ann
Supplementary Table S1: Immunohistochemical staining of Notch1-IC and HIPK2 in serial tissue arrays of 61 breast cancer samples. Supplementary Table S2: Semi-Quantitative analysis of Notch1-IC, phosphorylated Notch1-IC T2512, HIPK2, and Fbw7 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106b6b1748815c888b1cf061459b7456
https://doi.org/10.1158/0008-5472.22411064
https://doi.org/10.1158/0008-5472.22411064