Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Hee-Jin jung"'
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Jin Kim, Hye Soo Park, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1248 (2024)
2-Mercaptomethylbenzo[d]imidazole (2-MMBI) derivatives were designed and synthesized as tyrosinase (TYR) chelators using 2-mercaptomethylimidazole scaffolds. Seven of the ten 2-MMBI derivatives exhibited stronger inhibition of mushroom TYR activity t
Externí odkaz:
https://doaj.org/article/09e7f6b7bc374893b73f581c8cd94b62
Autor:
Hee Jin Jung, Hyeon Seo Park, Hye Soo Park, Hye Jin Kim, Dahye Yoon, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 29, Iss 17, p 4162 (2024)
Inspired by the potent tyrosinase inhibitory activity of phenolic compounds with a 2-phenylbenzo[d]thiazole scaffold, we explored phenolic compounds 1–15 with 2-phenylbenzo[d]oxazole, which is isosterically related to 2-phenylbenzo[d]thiazole, as n
Externí odkaz:
https://doaj.org/article/95b92502467c43a78d94d637211f1045
Autor:
Hye Jin Kim, Hee Jin Jung, Young Eun Kim, Daeun Jeong, Hyeon Seo Park, Hye Soo Park, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 29, Iss 12, p 2887 (2024)
Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity, benzylidene-3-methyl-2-thioxothiazolidin-4-one (BMTTZD) analogs 1–8 were prepared as potential tyrosinase inhib
Externí odkaz:
https://doaj.org/article/a8658f27ec3a47ee8b42e595485d6097
Autor:
Isoo Youn, Sujin Han, Hee Jin Jung, Sang Gyun Noh, Hae Young Chung, Yean Kyoung Koo, Sunhye Shin, Eun Kyoung Seo
Publikováno v:
Pharmaceuticals, Vol 16, Iss 12, p 1655 (2023)
Perilla frutense var. acuta (Lamiaceae) has been used to treat indigestion, asthma, and allergies in traditional medicine. In this study, luteolin 7-O-diglucuronide (1), apigenin 7-O-diglucuronide (2), and rosmarinic acid (3) were isolated from the l
Externí odkaz:
https://doaj.org/article/fa72c353fea9442386440a4dfa0ee3c3
Autor:
Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, YeJi Hwang, Yeongmu Jeong, Sojeong Hong, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 899-912 (2022)
As part of our continuous search for novel tyrosinase inhibitors, we designed 5,6-dihydroimindazo[2,1-b]thiazol-3(2H)-one (DHIT) derivatives based on the structure of MHY773; a potent tyrosinase inhibitor with a 2-iminothiazolidin-4-one template. Of
Externí odkaz:
https://doaj.org/article/a5e454fd81fe488cbb1512c293b5c205
Autor:
Jieun Lee, Hye Soo Park, Hee Jin Jung, Yu Jung Park, Min Kyung Kang, Hye Jin Kim, Dahye Yoon, Sultan Ullah, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1814 (2023)
Ten 2-mercaptobenzimidazole (2-MBI) analogs were synthesized as potential tyrosinase inhibitors because mercapto-containing compounds can bind to copper ions at the active site of tyrosinase to inhibit enzyme activity. Nine 2-MBI analogs showed sub-m
Externí odkaz:
https://doaj.org/article/18f948aa94fc4854b9bbd821818257a9
Autor:
Dahye Yoon, Min Kyung Kang, Hee Jin Jung, Sultan Ullah, Jieun Lee, Yeongmu Jeong, Sang Gyun Noh, Dongwan Kang, Yujin Park, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Molecules, Vol 28, Iss 8, p 3293 (2023)
(Z)-5-Benzylidene-2-phenylthiazol-4(5H)-one ((Z)-BPT) derivatives were designed by combining the structural characteristics of two tyrosinase inhibitors. The double-bond geometry of trisubstituted alkenes, (Z)-BPTs 1–14, was determined based on the
Externí odkaz:
https://doaj.org/article/83de3ac4d88c40939741c8536066e95e
Autor:
Dae Hyun Kim, Ye Ra Kim, EunJin Bang, Sugyeong Ha, Sang Gyun Noh, Byeong Moo Kim, Seong Ho Jeong, Hee Jin Jung, Ji Young Lee, Hae Young Chung
Publikováno v:
Endocrinology and Metabolism, Vol 36, Iss 1, Pp 171-184 (2021)
Background Protease-activated protein-2 (PAR2) has been reported to regulate hepatic insulin resistance condition in type 2 diabetes mice. However, the mechanism of lipid metabolism through PAR2 in obesity mice have not yet been examined. In liver, F
Externí odkaz:
https://doaj.org/article/0d855c34e9b4421f85ee925a14806f39
Autor:
Inkyu Choi, Yujin Park, Il Young Ryu, Hee Jin Jung, Sultan Ullah, Heejeong Choi, Chaeun Park, Dongwan Kang, Sanggwon Lee, Pusoon Chun, Hae Young Chung, Hyung Ryong Moon
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 37-50 (2021)
The β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold confers tyrosinase inhibitory activity, and in the present study, 16 (Z)-5-(substituted benzylidene)-3-phenyl-2-thioxooxazolidin-4-one analogues containing this scaffold were synthesized. Mushr
Externí odkaz:
https://doaj.org/article/89ae3e87421146fd846ffb9e9870e0f5
Autor:
Hyunyoung Kim, Hwaryeong Lee, Hee Jin Jung, Sang Gyun Noh, Isoo Youn, Hyunkyung Kwak, Yeju Lee, Sang-Jip Nam, Soosung Kang, Hae Young Chung, Eun Kyoung Seo
Publikováno v:
Molecules, Vol 28, Iss 6, p 2602 (2023)
A new bicyclic nonene, tsaokoic acid (1), was isolated from the fruits of Amomum tsao-ko, together with three known compounds (2–4). The structure of 1 was elucidated by analyzing spectroscopic data including 1D and 2D NMR spectra and compounds 2
Externí odkaz:
https://doaj.org/article/10b3823e53854877aafe02b2159f727f