Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Hee-Don Chae"'
Autor:
Jelena Levi, Caroline Guglielmetti, Timothy J. Henrich, John C. Yoon, Prafulla C. Gokhale, David A. Reardon, Juliet Packiasamy, Lyna Huynh, Hilda Cabrera, Marisa Ruzevich, Joseph Blecha, Michael J. Peluso, Tony L. Huynh, Sung-Min An, Mark Dornan, Anthony P. Belanger, Quang-Dé Nguyen, Youngho Seo, Hong Song, Myriam M. Chaumeil, Henry F. VanBrocklin, Hee-Don Chae
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Brown and brown-like adipose tissues have attracted significant attention for their role in metabolism and therapeutic potential in diabetes and obesity. Despite compelling evidence of an interplay between adipocytes and lymphocytes, the inv
Externí odkaz:
https://doaj.org/article/c7333532b2a4485eb5562ae7a4f52c49
Autor:
Hee-Don Chae, Jelena Levi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Macrophages play a multifaceted role in maintaining tissue homeostasis, fighting infections, and regulating cold-induced thermogenesis. The brown adipose tissue (BAT) is crucial for maintaining body temperature during cold exposure. Cold stress trigg
Externí odkaz:
https://doaj.org/article/ac29f2cced944a5ba84245cc0b1445c2
Autor:
Kaiming Zhang, Naoki Horikoshi, Shanshan Li, Alexander S. Powers, Mikhail A. Hameedi, Grigore D. Pintilie, Hee-Don Chae, Yousuf A. Khan, Carl-Mikael Suomivuori, Ron O. Dror, Kathleen M. Sakamoto, Wah Chiu, Soichi Wakatsuki
Publikováno v:
ACS Central Science, Vol 8, Iss 2, Pp 214-222 (2022)
Externí odkaz:
https://doaj.org/article/65bfa553069248ed93809a76bca79c14
Autor:
Minyoung Youn, Haigen Huang, Cheng Chen, Sharon Kam, Mark C. Wilkes, Hee-Don Chae, Kunju J. Sridhar, Peter L. Greenberg, Bertil Glader, Anupama Narla, Shuo Lin, Kathleen M. Sakamoto
Publikováno v:
Blood Advances, Vol 3, Iss 18, Pp 2751-2763 (2019)
The del(5q) myelodysplastic syndrome (MDS) is a distinct subtype of MDS, associated with deletion of the ribosomal protein S14 (RPS14) gene that results in macrocytic anemia. This study sought to identify novel targets for the treatment of patients w
Externí odkaz:
https://doaj.org/article/f293d06ad8ca4576845be250edd62e69
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13970 (2010)
RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T
Externí odkaz:
https://doaj.org/article/b3a7cade93ee4d1b8322ff8db4555e69
Autor:
Michael L. Cleary, Michael C. Bassik, Kathleen M. Sakamoto, Xiangshu Xiao, Justus Duyster, Gunnar Cario, Martin Schrappe, Hee-Don Chae, Michael C. Wei, Li Zhu, Stephen Hon Kit Wong, Johan Jeong, Ziming Weng, Edwin E. Jeng, David W. Morgens, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Dasatinib is a multi-tyrosine kinase inhibitor approved for treatment of Ph+ acute lymphoblastic leukemia (ALL), but its efficacy is limited by resistance. Recent preclinical studies suggest that dasatinib may be a candidate therapy in additional ALL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a5a232d54f4cb298df8b6f2391088a
https://doi.org/10.1158/0008-5472.c.6510546.v1
https://doi.org/10.1158/0008-5472.c.6510546.v1
Autor:
Michael L. Cleary, Michael C. Bassik, Kathleen M. Sakamoto, Xiangshu Xiao, Justus Duyster, Gunnar Cario, Martin Schrappe, Hee-Don Chae, Michael C. Wei, Li Zhu, Stephen Hon Kit Wong, Johan Jeong, Ziming Weng, Edwin E. Jeng, David W. Morgens, Kyuho Han, Chiou-Hong Lin, Jesús Duque-Afonso
Unbiased shRNA library screening and global transcriptome analyses reveal mechanisms that modulate dasatinib sensitivity and suggest therapeutic strategies to improve outcome of patients with acute lymphoblastic leukemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07fd1c5d294edc7195dfdda333c4730d
https://doi.org/10.1158/0008-5472.22420047.v1
https://doi.org/10.1158/0008-5472.22420047.v1
Autor:
Mark C Wilkes, Hee-Don Chae, Vanessa Scanlon, Alma-Martina Cepika, Ethan P Wentworth, Mallika Saxena, Ascia Eskin, Zugen Chen, Bert Glader, Maria Grazia Roncarolo, Stanley F Nelson, Kathleen M Sakamoto
Publikováno v:
Stem Cells.
Diamond Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with severe anemia, congenital malformations, and an increased risk of developing cancer. The chromatin-binding special AT-rich sequence-binding protein-1 (SATB1) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc7fc5431bbd9fb9b54755b5e3946710
https://doi.org/10.1093/stmcls/sxad025
https://doi.org/10.1093/stmcls/sxad025
Autor:
Kailen Mark, Marilee Robbins, Anna Gamble, Hee-Don Chae, Michael Bassik, Kyuho Han, Kathleen M. Sakamoto
Publikováno v:
Blood. 140:8870-8871
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05e1de38f61bb17f70d0b78a5dcd9e13
https://doi.org/10.1182/blood-2022-167429
https://doi.org/10.1182/blood-2022-167429