Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Hee-Chul Ahn"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116459- (2024)
Ubiquitin-specific protease (USP), an enzyme catalyzing protein deubiquitination, is involved in biological processes related to metabolic disorders and cancer proliferation. We focused on constructing predictive models tailored to unveil compounds b
Externí odkaz:
https://doaj.org/article/cf4d82f73e0643c9b1fdbc09f690ff0f
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1440-1457 (2020)
The activation of c-Jun N-terminal kinases (JNKs) plays an important role in physiological processes including neuronal function, immune activity, and development, and thus, JNKs have been a therapeutic target for various diseases such as neurodegene
Externí odkaz:
https://doaj.org/article/43e7cb1b698640da9d3a4027d3c6fbfa
Publikováno v:
Plants, Vol 11, Iss 24, p 3585 (2022)
Non-alcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease with limited treatment options. The widely distributed plant Aloe vera has shown protective effects against NASH in animals, yet the precise mechanism remains unknown. I
Externí odkaz:
https://doaj.org/article/b559c77e3ffc491bbee51790993bf7b0
Autor:
Ngoc Minh Nguyen, Men Thi Hoai Duong, Bich Phuong Bui, Phuong Linh Nguyen, Xiaozhen Chen, Jungsook Cho, Hee-Chul Ahn
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10590 (2022)
Our structure-based virtual screening of the FDA-approved drug library has revealed that sonidegib, a smoothened antagonist clinically used to treat basal cell carcinoma, is a potential c-Jun N-terminal kinase 3 (JNK3) inhibitor. This study investiga
Externí odkaz:
https://doaj.org/article/5669b7f8c1fb42c8b26fa106e980b59a
Autor:
Men Thi Hoai Duong, Hee-Chul Ahn
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1900 (2022)
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are related to cell proliferation, gene expression, and cell death. JNK isoform 3 (JNK3) is an important therapeutic target in varieties of path
Externí odkaz:
https://doaj.org/article/1910567bcefd4ec58c74645a482252f4
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1175 (2022)
Malate dehydrogenase (MDH), which catalyzes a reversible conversion of L-malate to oxaloacetate, plays essential roles in common metabolic processes, such as the tricarboxylic acid cycle, the oxaloacetate–malate shuttle, and the glyoxylate cycle. M
Externí odkaz:
https://doaj.org/article/8e39df3009fd4d299cce8670b42d4063
Publikováno v:
FEBS Open Bio, Vol 9, Iss 10, Pp 1713-1725 (2019)
Transcriptional regulator proteins are closely involved in essential survival strategies in bacteria. AcrR is a one‐component allosteric repressor of the genes associated with lipid transport and antibiotic resistance. When fatty acid ligands bind
Externí odkaz:
https://doaj.org/article/0bc95aa3dd404d97948eb4f5e1ee19d6
Autor:
Phuong Linh Nguyen, Bich Phuong Bui, Men Thi Hoai Duong, Kyeong Lee, Hee-Chul Ahn, Jungsook Cho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 9061 (2021)
The c-Jun N-terminal kinases (JNKs) are implicated in many neuropathological conditions, including neurodegenerative diseases. To explore potential JNK3 inhibitors from the U.S. Food and Drug Administration-approved drug library, we performed structu
Externí odkaz:
https://doaj.org/article/4429aa46ffaf42b6be83eb8467fced3b
Autor:
Kevin G. Hicks, Ahmad A. Cluntun, Heidi L. Schubert, Sean R. Hackett, Jordan A. Berg, Paul G. Leonard, Mariana A. Ajalla Aleixo, Youjia Zhou, Alex J. Bott, Sonia R. Salvatore, Fei Chang, Aubrie Blevins, Paige Barta, Samantha Tilley, Aaron Leifer, Andrea Guzman, Ajak Arok, Sarah Fogarty, Jacob M. Winter, Hee-Chul Ahn, Karen N. Allen, Samuel Block, Iara A. Cardoso, Jianping Ding, Ingrid Dreveny, William C. Gasper, Quinn Ho, Atsushi Matsuura, Michael J. Palladino, Sabin Prajapati, Pengkai Sun, Kai Tittmann, Dean R. Tolan, Judith Unterlass, Andrew P. VanDemark, Matthew G. Vander Heiden, Bradley A. Webb, Cai-Hong Yun, Pengkai Zhao, Bei Wang, Francisco J. Schopfer, Christopher P. Hill, Maria Cristina Nonato, Florian L. Muller, James E. Cox, Jared Rutter
Publikováno v:
Science
Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry int
Autor:
Ngoc Minh Nguyen, Men Thi Hoai Duong, Phuong Linh Nguyen, Bich Phuong Bui, Hee-Chul Ahn, Jungsook Cho
Publikováno v:
Biomoleculestherapeutics. 30(5)
Efonidipine, a calcium channel blocker, is widely used for the treatment of hypertension and cardiovascular diseases. In our preliminary study using structure-based virtual screening, efonidipine was identified as a potential inhibitor of c-Jun N-ter