Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hee Jong Lim"'
Autor:
Sae-Bom Yoon, Hyowon Hong, Hee-Jong Lim, Ji Hye Choi, Yoon Pyo Choi, Seong Wook Seo, Hyuk Woo Lee, Chong Hak Chae, Woo-Kyu Park, Hyun Young Kim, Daeyoung Jeong, Tran Quang De, Chang-Seon Myung, Heeyeong Cho
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 3, Pp 1093-1109 (2023)
Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal enzyme in the Toll-like receptor (TLR)/MYD88 dependent signaling pathway, which is highly activated in rheumatoid arthritis tissues and activated B cell-like diffuse large B-cell lymphom
Externí odkaz:
https://doaj.org/article/06e3ac574c0849ed8c4b61044cdc2a36
Autor:
Eun-Jin Han, Hyun Young Kim, Naeun Lee, Nam-Hoon Kim, Seung-Ah Yoo, H. Moo Kwon, Dae-Myung Jue, Yune-Jung Park, Chul-Soo Cho, Tran Quang De, Dae Young Jeong, Hee-Jong Lim, Woo Kyu Park, Ge Hyeong Lee, Heeyeong Cho, Wan-Uk Kim
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 261-273 (2017)
Nuclear factor of activated T cells 5 (NFAT5) has been implicated in the pathogenesis of various human diseases, including cancer and arthritis. However, therapeutic agents inhibiting NFAT5 activity are currently unavailable. To discover NFAT5 inhibi
Externí odkaz:
https://doaj.org/article/36a508b094274a66858f7b599d964bb6
Autor:
Nam-Hoon Kim, Yune-Jung Park, Tran Quang De, Dae-Myung Jue, Naeun Lee, H. Moo Kwon, Ge Hyeong Lee, Eun-Jin Han, Hyun Young Kim, Dae Young Jeong, Wan-Uk Kim, Chul-Soo Cho, Seung-Ah Yoo, Hee-Jong Lim, Woo Kyu Park, Heeyeong Cho
Publikováno v:
EBioMedicine, Vol 18, Iss C, Pp 261-273 (2017)
EBioMedicine
EBIOMEDICINE(18)
EBioMedicine
EBIOMEDICINE(18)
Nuclear factor of activated T cells 5 (NFAT5) has been implicated in the pathogenesis of various human diseases, including cancer and arthritis. However, therapeutic agents inhibiting NFAT5 activity are currently unavailable. To discover NFAT5 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d09edda84c986f41ef69417004af2a
http://www.sciencedirect.com/science/article/pii/S2352396417301342
http://www.sciencedirect.com/science/article/pii/S2352396417301342
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:51-54
Synthesis, SAR study and BACE1 inhibitory activity of (3S,4S)-4-aminopyrrolidine-3-ol derivatives (2) were described. The compound 7c exhibited more inhibition activity than 11a (IC50: 0.05μM vs 0.12μM, respectively), but the latter was more effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bc4e439432dcdbd2db40bb567c0d7c
https://doi.org/10.1016/j.bmcl.2015.11.033
https://doi.org/10.1016/j.bmcl.2015.11.033
Publikováno v:
Synthetic Communications. 44:1876-1880
2-Aminoimidazolidin-4-ones have been synthesized by using di-2-pyridyl thiocarbonate (DPT), taking the thioureas tethered to amides as the starting materials. Both the primary amides and secondary amides have been subjected to this cyclization method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d348e75358175ea1692b7c1109a6997f
https://doi.org/10.1080/00397911.2013.827724
https://doi.org/10.1080/00397911.2013.827724
Autor:
Ah Reum Han, Hee Jong Lim, Eun Kyoung Seo, Song Wha Chae, Jeong Yeon Rhie, Jung Hyun Park, Hwa Jeong Lee
Publikováno v:
Journal of Natural Products. 76:2277-2281
The expression of P-glycoprotein (P-gp), an ATP-dependent efflux transporter, is closely associated with the failure of chemotherapy and drug absorption. Two synthesized optically active phenylbutenoid dimers, 3S-(3,4-dimethoxyphenyl)-4R-{(E)-3,4-dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::377f7e230b000e32273691367f6c7c6f
https://doi.org/10.1021/np4004917
https://doi.org/10.1021/np4004917
Publikováno v:
Bulletin of the Korean Chemical Society. 34:2829-2832
E-mail: yink@pcu.ac.krReceived May 30, 2013, Accepted June 25, 2013Key Words : Phenylpyrazole, PI3 kinase gamma, In vitro assay, SAR, Inhibitory activityPhosphatidylinositol-3-kinase gamma (PI3Kγ), with itscatalytic subunit P110γ and regulatory sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e20924d57f055e8bb8aa6aab7343a5e7
https://doi.org/10.5012/bkcs.2013.34.9.2829
https://doi.org/10.5012/bkcs.2013.34.9.2829
Publikováno v:
European Journal of Organic Chemistry. 2012:2542-2548
Intramolecular cyclization of thioureas or ureas tethered to amides afforded 2-iminohydantoins and 2-amino-1H-imidazol-4(5H)-ones in very high yields (87–100 %) regardless of the substituent (alkyls or aryls). This reaction proceeds through carbodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4326504c6c251f09e2450f607ed56f86
https://doi.org/10.1002/ejoc.201200025
https://doi.org/10.1002/ejoc.201200025
Autor:
Dongwoo Shin, Ji-Hee Suh, Bum Tae Kim, Jun Seob Kim, Sung-Koo Kim, Da-Hyeong Cho, Tae-Jun Yang, Paul Heo, Hee-Jong Lim, Ki-Sing Lee, Dae-Hyuk Kweon
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:5380-5383
We show that 3-[4-(4-methoxyphenyl)piperazin-1-yl]piperidin-4-yl biphenyl-4-carboxylate (C10), screened out of a chemical library, selectively kills bacterial persisters that tolerate antibiotic treatment but does not affect normal antibiotic-sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52e55f476bf215bee4db2f8d1de3aece
https://doi.org/10.1128/aac.00708-11
https://doi.org/10.1128/aac.00708-11
Autor:
Jeonghyun Chu, Dong Hoon Suh, Hee-Jong Lim, Ah Reum Han, Eun Kyoung Seo, Song Wha Chae, Gehyung Lee, Hwa Jeong Lee
Publikováno v:
Journal of Natural Products. 74:1817-1821
The total synthesis of optically active phenylbutenoid dimers 1, 3, and ent-3 is described. The key step to access optically active cyclohexene rings was achieved by Diels-Alder reaction of chiral acryloyloxazolinone 9 and phenylbetadiene 10.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31afcbc9f7ff8757e44198f28468e633
https://doi.org/10.1021/np100942e
https://doi.org/10.1021/np100942e