Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hedy Chan"'
Autor:
Erik Gjerstad, James W. Janc, John R. Somoza, Christine Luong, Bradley A. Katz, Erik Verner, Mary E. McGrath, Kyle Mortara, Jie Tang, Hedy Chan, Steven R. Williams, Richard L. Mackman, Wendy B. Young, Paul A. Sprengeler, Joseph D. Ho
Publikováno v:
Journal of Molecular Biology. 344:527-547
A site-directed mutant of the serine protease urokinase-type plasminogen activator (uPA), was produced to assess the contribution of the Ser190 side-chain to the affinity and selectivity of lead uPA inhibitors in the absence of other differences pres
Publikováno v:
Protein Expression and Purification. 12:361-370
Human tissue kallikrein is a serine protease implicated in the pathology of various inflammatory disorders. As one of the two principal enzymes that generate proinflammatory kinin peptides in vivo, tissue kallikrein represents an attractive target fo
Publikováno v:
Journal of Investigative Dermatology. 103(4):569-575
Keratinocyte intercellular adhesion molecule-1 (ICAM-1) is important in mediating retention of T cells within the epidermal compartment. To determine if antisense oligonucleotides designed to hybridize to various ICAM-1 mRNA regions could selectively
Publikováno v:
Journal of Liposome Research. 3:85-102
Antisense oligonucleotides bind to specific mRNA or pre-mRNA sequences through Watson-Crick base pairing, resulting in decreased expression of the targeted protein. The use of cationic lipids to enhance cellular uptake of antisense oligonucleotides i
Publikováno v:
Journal of Biological Chemistry. 266:18162-18171
Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein expressed on the surface of both hemopoietic and nonhemopoietic cells that mediates, in part, the emigration of leukocytes out of the vasculature. Expression of ICAM-1 on the surface of hum
Publikováno v:
Molecular and Cellular Biology. 11:47-54
Autor:
Hedy Chan, Erik Gjerstad, Jun Sampang, Jing Yuan, James W. Janc, Jeri Beltman, Margaret Nguyen, James M. Clark
Publikováno v:
Protein expression and purification. 49(1)
Tryptases are trypsin-like serine proteases whose expression is restricted to cells of hematopoietic origin, notably mast cells. gamma-Tryptase, a recently described member of the family also known as transmembrane tryptase (TMT), is a membrane-bound
Autor:
David Sperandio, Bradley A. Katz, Paul A. Sprengeler, Kyle Mortara, Hedy Chan, Manjiri Ghate, William D. Shrader, Joseph D. Ho, John R. Somoza, Christine Luong, Mary E. McGrath
Publikováno v:
Structure (London, England : 1993). 11(9)
Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component
Autor:
James T. Palmer, Joseph D. Ho, Yana Meltser, Joseph J. Buggy, Kyle Elrod, John R. Somoza, Hedy Chan, Kyle Mortara
Publikováno v:
Acta crystallographica. Section D, Biological crystallography. 58(Pt 12)
Cathepsin F is a cysteine protease believed to be involved in the antigen-presenting process of the class II major histocompatibility complex (MHC-II) in macrophages. It has been expressed, purified and crystallized. A complete data set to a resoluti
Publikováno v:
Protein expression and purification. 15(3)
Tryptase, a serine protease, is the major protein component in mast cells. In an animal model of asthma, tryptase has been established as an important mediator of inflammation and late airway responses induced by antigen challenge. Human tryptase is