Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Hedwig S"'
Autor:
Talitha C. F. Spanjersberg, Loes A. Oosterhoff, Hedwig S. Kruitwagen, Noortje A. M. van den Dungen, Johannes C. M. Vernooij, Folkert W. Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G. van Steenbeek
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed. We analyzed transcriptomes from cultured endothelial cells and vascular smoot
Externí odkaz:
https://doaj.org/article/084d9af137ee4c1b8e300e79be3a0038
Autor:
Maya W. Haaker, Hedwig S. Kruitwagen, Arie B. Vaandrager, Martin Houweling, Louis C. Penning, Martijn R. Molenaar, Monique E. vanWolferen, Loes A. Oosterhoff, Bart Spee, J. Bernd Helms
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 34, Iss 1, Pp 132-138 (2020)
Abstract Background Hepatic lipidosis is increasing in incidence in the Western world, with cats being particularly sensitive. When cats stop eating and start utilizing their fat reserves, free fatty acids (FFAs) increase in blood, causing an accumul
Externí odkaz:
https://doaj.org/article/9e1ab320d6b74ca9bb639a32d61656eb
Autor:
Kiona S. de Nies, Hedwig S. Kruitwagen, Giora van Straten, Leonie W. L. van Bruggen, Joris H. Robben, Baukje A. Schotanus, Ies Akkerdaas, Anne Kummeling
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-8 (2019)
Abstract Background Vascular access port (VAP) systems are widely used in human medicine to provide long-term venous access. However, in veterinary medicine the use of VAP systems is not common practice and publications on their potential application
Externí odkaz:
https://doaj.org/article/1a711196372b477697ee532aa0708273
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Ingrid G.W.H. Vernooij, Ingrid M. Schrall, Monique E. van Wolferen, Farah Bannink, Camille Roesch, Lisa van Uden, Martijn R. Molenaar, J. Bernd Helms, Guy C.M. Grinwis, Monique M.A. Verstegen, Luc J.W. van der Laan, Meritxell Huch, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 822-830 (2017)
Summary: Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the p
Externí odkaz:
https://doaj.org/article/1b75311bbf3843328b88a26d9590e37a
Autor:
Loes A. Oosterhoff, Hedwig S. Kruitwagen, Monique E. van Wolferen, Bas W.M. van Balkom, Michal Mokry, Nico Lansu, Noortje A.M. van den Dungen, Louis C. Penning, Talitha C.F. Spanjersberg, Johannes W. de Graaf, Tomas Veenendaal, Flin Zomerdijk, Joost O. Fledderus, Bart Spee, Frank G. van Steenbeek
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Vasculature performs a critical function in tissue homeostasis, supply of oxygen and nutrients, and the removal of metabolic waste products. Vascular problems are implicated in a large variety of pathologies and accurate in vitro models resembling na
Externí odkaz:
https://doaj.org/article/d3bcd76059fd4137b465861aad4ad624
Autor:
Nina Kramer, Barbara Pratscher, Andre M. C. Meneses, Waltraud Tschulenk, Ingrid Walter, Alexander Swoboda, Hedwig S. Kruitwagen, Kerstin Schneeberger, Louis C. Penning, Bart Spee, Matthias Kieslinger, Sabine Brandt, Iwan A. Burgener
Publikováno v:
Cells, Vol 9, Iss 4, p 822 (2020)
Functional intestinal disorders constitute major, potentially lethal health problems in humans. Consequently, research focuses on elucidating the underlying pathobiological mechanisms and establishing therapeutic strategies. In this context, intestin
Externí odkaz:
https://doaj.org/article/e2c51234984b4abeac4ab23a854b1524
Autor:
Hedwig S. Kruitwagen, Loes A. Oosterhoff, Monique E. van Wolferen, Chen Chen, Sathidpak Nantasanti Assawarachan, Kerstin Schneeberger, Anne Kummeling, Giora van Straten, Ies C. Akkerdaas, Christel R. Vinke, Frank G. van Steenbeek, Leonie W.L. van Bruggen, Jeannette Wolfswinkel, Guy C.M. Grinwis, Sabine A. Fuchs, Helmuth Gehart, Niels Geijsen, Robert G. Vries, Hans Clevers, Jan Rothuizen, Baukje A. Schotanus, Louis C. Penning, Bart Spee
Publikováno v:
Cells, Vol 9, Iss 2, p 410 (2020)
The shortage of liver organ donors is increasing and the need for viable alternatives is urgent. Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with liver transplantation. Unfortunately, hepatocytes cannot be expand
Externí odkaz:
https://doaj.org/article/c674d01025924804a5b649c947eca488
Autor:
Sathidpak Nantasanti, Bart Spee, Hedwig S. Kruitwagen, Chen Chen, Niels Geijsen, Loes A. Oosterhoff, Monique E. van Wolferen, Nicolas Pelaez, Hille Fieten, Richard W. Wubbolts, Guy C. Grinwis, Jefferson Chan, Meritxell Huch, Robert R.G. Vries, Hans Clevers, Alain de Bruin, Jan Rothuizen, Louis C. Penning, Baukje A. Schotanus
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 895-907 (2015)
The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a relevant large animal model is essential but not yet established.
Externí odkaz:
https://doaj.org/article/1abf448ce02c4f37b5e21cdc6b0ded40
Autor:
Lindsay Van den Bossche, Vivien A C Schoonenberg, Iwan A Burgener, Louis C Penning, Ingrid M Schrall, Hedwig S Kruitwagen, Monique E van Wolferen, Guy C M Grinwis, Anne Kummeling, Jan Rothuizen, Jeroen F van Velzen, Nikolas Stathonikos, Martijn R Molenaar, Bernd J Helms, Jos F H M Brouwers, Bart Spee, Frank G van Steenbeek
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186491 (2017)
Non-alcoholic fatty liver disease (NAFLD) is a poorly understood multifactorial pandemic disorder. One of the hallmarks of NAFLD, hepatic steatosis, is a common feature in canine congenital portosystemic shunts. The aim of this study was to gain deta
Externí odkaz:
https://doaj.org/article/d24b3c0da950484b9acfde4701c548bc
Autor:
Hedwig S. Kruitwagen, Bart Spee, Hille Fieten, Frank G. van Steenbeek, Baukje A. Schotanus, Louis C. Penning
Publikováno v:
European Medical Journal Hepatology, Vol 2, Iss 1, Pp 48-54 (2014)
Alternatives for liver transplantation in severe liver disease are urgently needed in view of the limited availability of donor livers. The use of embryonic stem cells (ES) or hepatic progenitor cells (HPC) has been investigated in mice models of acu
Externí odkaz:
https://doaj.org/article/262b0b46a50349f095c9fcb7b404828a