Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Antitumor T-cell Function.

Autor: Chakraborty P; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Parikh RY; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Choi S; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Tran D; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Gooz M; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina., Hedley ZT; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Kim DS; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Pytel D; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.; Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland., Kang I; Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Nadig SN; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Beeson GC; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina., Ball L; Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston, South Carolina., Mehrotra M; Department of Pathology & Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina., Wang H; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Berto S; Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina., Palanisamy V; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Li H; Department of Public Health, Medical University of South Carolina, Charleston, South Carolina., Chatterjee S; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina., Rodriguez PC; Department of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida., Maldonado EN; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, South Carolina., Diehl JA; Department of Biochemistry, Case Western University, Cleveland, Ohio., Gangaraju VK; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina., Mehrotra S; Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.; Department of Microbiology & Immunology, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.

Publikováno v: Cancer research [Cancer Res] 2022 May 16; Vol. 82 (10), pp. 1969-1990.