Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hedieh Barkhordarian"'
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 1, Pp 74-81 (2005)
A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Aβ) from its soluble monomeric form into various aggregated morphologies in the brain. Preventing aggregation of Aβ is being actively pursued as a p
Externí odkaz:
https://doaj.org/article/0d5408e3da704e9aa72ea492ae4b3504
Autor:
Diandra Martinez-Cano, Rashmi Ravichandran, Huong Le, H. Edward Wong, Bharat Jagannathan, Erik J. Liu, William Bailey, Jane Yang, Kelli Matthies, Hedieh Barkhordarian, Bhavana Shah, Nithya Srinivasan, Jun Zhang, Angel Hsu, Jette Wypych, Jennitte Stevens, Deirdre Murphy Piedmonte, Les P. Miranda, Lauren Carter, Michael Murphy, Neil P. King, Neil Soice
Publikováno v:
Process Biochemistry. 129:241-256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cdb05762cb3b98d4e5226e4599710f5
https://doi.org/10.1016/j.procbio.2023.03.014
https://doi.org/10.1016/j.procbio.2023.03.014
Autor:
Pavan Ghattyvenkatakrishna, Xin Zhang, Hedieh Barkhordarian, Joon Huh, Jonathan Lull, Natalia Gomez
Publikováno v:
Journal of Biotechnology. 304:70-77
Secreted recombinant proteins can aggregate during cell culture. We studied a poorly-behaved bispecific scaffold that increasingly aggregated (up to 62% high molecular weight species, HMW) as a function of culture time in a fed-batch and intensified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea56cf0c31be85db38bee3b489a6675
https://doi.org/10.1016/j.jbiotec.2019.08.001
https://doi.org/10.1016/j.jbiotec.2019.08.001
Autor:
Chung-Jr Huang, Li Zhang, Chris Gutierrez, Hedieh Barkhordarian, Ambhaikar Malhar R, Jonathan Lull, Natalia Gomez
Publikováno v:
Biotechnology Progress. 33:490-499
High cell density (HCD) culture increases recombinant protein productivity via higher biomass. Compared to traditional fed-batch cultures, HCD is achieved by increased nutrient availability and removal of undesired metabolic components via regular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2839cb95dedd5b806d5941d879f8c578
https://doi.org/10.1002/btpr.2418
https://doi.org/10.1002/btpr.2418
Autor:
Kristi Daris, Tharmala Tharmalingam, Pheng Yam, Nicole Tejeda, Sam Yaghmour, Fang Lu, Jennitte Stevens, Chetan T. Goudar, Hedieh Barkhordarian, Trent P. Munro
Publikováno v:
Biotechnology Progress
Regulatory guidelines require the sponsors to provide assurance of clonality of the production cell line, and when such evidence is not available, additional studies are typically required to further ensure consistent long-term manufacturing of the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a33d0562eace6e57e2d12e7153fb05e
https://pubmed.ncbi.nlm.nih.gov/29882350
https://pubmed.ncbi.nlm.nih.gov/29882350
Autor:
Natalia, Gomez, Malhar, Ambhaikar, Li, Zhang, Chung-Jr, Huang, Hedieh, Barkhordarian, Jonathan, Lull, Chris, Gutierrez
Publikováno v:
Biotechnology progress. 33(2)
High cell density (HCD) culture increases recombinant protein productivity via higher biomass. Compared to traditional fed-batch cultures, HCD is achieved by increased nutrient availability and removal of undesired metabolic components via regular me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf73ec342bb035da00370fd7feb13557
https://pubmed.ncbi.nlm.nih.gov/27977914
https://pubmed.ncbi.nlm.nih.gov/27977914
Publikováno v:
Journal of Molecular Biology. 368:1132-1144
Protein misfolding and aggregation are pathological aspects of numerous neurodegenerative diseases. Aggregates of alpha-synuclein are major components of the Lewy bodies and Lewy neurites associated with Parkinson's Disease (PD). A natively unfolded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68806b2c98b4c390c6c81e4de1e2048e
https://doi.org/10.1016/j.jmb.2007.02.089
https://doi.org/10.1016/j.jmb.2007.02.089
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 1, Pp 74-81 (2005)
A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Abeta) from its soluble monomeric form into various aggregated morphologies in the brain. Preventing aggregation of Abeta is being actively pursued as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1960ab6d63e7f4eaf60c0fe41069d749
https://doi.org/10.1016/j.nbd.2005.02.003
https://doi.org/10.1016/j.nbd.2005.02.003
Autor:
Dwight Winters, Steve Smith, Mark Berge, Eleanor Le, Zhongqi Zhang, Robert W. Hong, Mark Leo Michaels, Jennifer Liu, Katariina M. Hutterer, Frank Abroson, Ed Belouski, Randy Ira Hecht, Bhavana Shah, Hedieh Barkhordarian
Publikováno v:
Biotechnology and bioengineering. 109(11)
High levels of translational errors, both truncation and misincorporation in an Fc-fusion protein were observed. Here, we demonstrate the impact of several commercially available codon optimization services, and compare to a targeted strategy. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d0922b62029d4aee7d1c2f7f3aea88
https://pubmed.ncbi.nlm.nih.gov/22573571
https://pubmed.ncbi.nlm.nih.gov/22573571
Publikováno v:
Protein engineering, designselection : PEDS. 19(11)
Isolation of antibodies to antigens that are either unstable, exist in multiple morphologies or have very limited availability can be prohibitively difficult. Here we describe a novel technique combining the capabilities of phage display antibody tec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3c76963fb15583c8c7780cf479bfe5
https://pubmed.ncbi.nlm.nih.gov/16984950
https://pubmed.ncbi.nlm.nih.gov/16984950