Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex

Autor: Nikos Pinotsis, Anna Krüger, Nicolas Tomas, Spyros D. Chatziefthymiou, Claudia Litz, Simon Arnold Mortensen, Mamadou Daffé, Hedia Marrakchi, Garabed Antranikian, Matthias Wilmanns

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract The identification and characterization of enzyme function is largely lacking behind the rapidly increasing availability of large numbers of sequences and associated high-resolution structures. This is often hampered by lack of knowledge on

Externí odkaz: https://doaj.org/article/8dd984e6035b406ba13061303ee8359a

Telacebec Interferes with Virulence Lipid Biosynthesis Protein Expression and Sensitizes to Other Antibiotics

Autor: Zhiyu Zhou, Ruddy Wattiez, Patricia Constant, Hedia Marrakchi, Karine Soetaert, Vanessa Mathys, Véronique Fontaine, Sheng Zeng

Publikováno v: Microorganisms, Vol 11, Iss 10, p 2469 (2023)

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a public health issue, particularly due to multi-drug-resistant Mtb. The bacillus is wrapped in a waxy envelope containing lipids acting as essential virulence factors, accounting

Externí odkaz: https://doaj.org/article/884c49f0ab4d4299b93d4b551b4bfbf8

The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria[S]

Autor: Nguyen-Hung Le, Marie Locard-Paulet, Alexandre Stella, Nicolas Tomas, Virginie Molle, Odile Burlet-Schiltz, Mamadou Daffé, Hedia Marrakchi

Publikováno v: Journal of Lipid Research, Vol 61, Iss 8, Pp 1180-1191 (2020)

Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique a

Externí odkaz: https://doaj.org/article/97e6fde4b6f14cd199609b015eeafd89

The protein kinase PknB negatively regulates biosynthesis and trafficking of mycolic acids in mycobacteria[S]

Autor: Virginie Molle, Alexandre Stella, Nicolas Tomas, Mamadou Daffé, Odile Burlet-Schiltz, Marie Locard-Paulet, Hedia Marrakchi, Nguyen-Hung Le

Publikováno v: Journal of Lipid Research, Vol 61, Iss 8, Pp 1180-1191 (2020)
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2020, 61 (8), pp.1180-1191. ⟨10.1194/jlr.RA120000747⟩
J Lipid Res

Mycobacterium tuberculosis is the causative agent of tuberculosis and remains one of the most widespread and deadliest bacterial pathogens in the world. A distinguishing feature of mycobacteria that sets them apart from other bacteria is the unique a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a027b0ee0c25fb5809edbe04ebd132
http://www.sciencedirect.com/science/article/pii/S002222752043487X

Characterization of the mycobacterial acyl-CoA carboxylase holo complexes reveals their functional expansion into amino acid catabolism.

Autor: Matthias T Ehebauer, Michael Zimmermann, Arjen J Jakobi, Elke E Noens, Daniel Laubitz, Bogdan Cichocki, Hedia Marrakchi, Marie-Antoinette Lanéelle, Mamadou Daffé, Carsten Sachse, Andrzej Dziembowski, Uwe Sauer, Matthias Wilmanns

Publikováno v: PLoS Pathogens, Vol 11, Iss 2, p e1004623 (2015)

Biotin-mediated carboxylation of short-chain fatty acid coenzyme A esters is a key step in lipid biosynthesis that is carried out by multienzyme complexes to extend fatty acids by one methylene group. Pathogenic mycobacteria have an unusually high re

Externí odkaz: https://doaj.org/article/9a76312a97654e8193204c9108da9bfa