Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hedi Sinijärv"'
Publikováno v:
Biophysical Chemistry. 228:17-24
Dissociation of the complex of a ligand and a protein usually follows the kinetic profile of the first order process and the rate of dissociation is not affected by the presence of competitive ligands. We discovered that dissociation of the complex b
Publikováno v:
Analytical biochemistry. 531
High demand for inhibitors regulating the activity of protein kinases has stimulated the quest for high throughput and reliable compound screening assays. Here we introduce a method applying a non-metal photoluminescent probe ARC-Lum(Fluo) for determ
Autor:
Hedi Sinijärv, Sergiy Kostenko, Ugo Moens, Asko Uri, Angela Vaasa, Erki Enkvist, Marie Kriisa
Publikováno v:
ChemBioChem. 16:312-319
Bisubstrate inhibitors of protein kinases associate simultaneously with two substrate-binding sites of the kinase and thus potentially possess better inhibitory potency and selectivity than inhibitors binding to only the conserved ATP-site of the kin
Autor:
Jürgen Vahter, Siiri Saaver, Barbara Guerra, Asko Uri, Darja Lavogina, Hedi Sinijärv, Erki Enkvist, Olaf-Georg Issinger, Gerda Raidaru, Kaido Viht
Publikováno v:
Viht, K, Saaver, S, Vahter, J, Enkvist, E, Lavogina, D, Sinijarv, H, Raidaru, G, Guerra, B, Issinger, O-G & Uri, A 2015, ' Acetoxymethyl ester of tetrabromobenzimidazole-peptoid conjugate for inhibition of protein kinase CK2 in living cells ', Bioconjugate Chemistry, vol. 26, no. 12, pp. 2324-2335 . https://doi.org/10.1021/acs.bioconjchem.5b00383
CK2 is a ubiquitous serine/threonine protein kinase, which has the potential to catalyze the generation of a large proportion of the human phosphoproteome. Due to its role in numerous cellular functions and general anti-apoptotic activity, CK2 is an
Autor:
Aleksandr Frorip, Mai Rosenberg, Aleksander Y. Zemchenkov, Artur Kuznetsov, Hedi Sinijärv, Georgi A Konoplev, Alar Sünter, Aleksandr M Vasilevsky, Roman Gerasimchuk
Publikováno v:
Nephrology Dialysis Transplantation. 31:i500-i501