Výsledky vyhledávání - "Heddwen L Brooks"

Akademický článek

Menopause causes metabolic and cognitive impairments in a chronic cerebral hypoperfusion model of vascular contributions to cognitive impairment and dementia

Autor: Olivia J. Gannon, Janvie S. Naik, David Riccio, Febronia M. Mansour, Charly Abi-Ghanem, Abigail E. Salinero, Richard D. Kelly, Heddwen L. Brooks, Kristen L. Zuloaga

Publikováno v: Biology of Sex Differences, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract Background The vast majority of women with dementia are post-menopausal. Despite clinical relevance, menopause is underrepresented in rodent models of dementia. Before menopause, women are less likely than men to experience strokes, obesity,

Externí odkaz: https://doaj.org/article/5ab8287ee17e4496b9e92897d352f872

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Akademický článek

CD4+ T Cell‐Specific Proteomic Pathways Identified in Progression of Hypertension Across Postmenopausal Transition

Autor: Joshua A. Uhlorn, Nathaniel A. Husband, Melissa J. Romero‐Aleshire, Caitlin Moffett, Merry L. Lindsey, Paul R. Langlais, Heddwen L. Brooks

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 2 (2021)

Background Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell‐dependent immune activation and development of angiotensin II (Ang II) hyperten

Externí odkaz: https://doaj.org/article/3520492ab945449d81eb77f9ec718cd2

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Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice

Autor: Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 323:H845-H860

Cerebral parenchymal arterioles from menopause mice showed increased myogenic tone. We identified an impairment in smooth muscle cell BKCa channel activity, without a reduction in endothelium-dependent dilation or nitric oxide production. Microvascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2731dbf0c5f8b8226f3b9d49617bf25
https://doi.org/10.1152/ajpheart.00276.2022

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Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension

Autor: Megan A. Sylvester, Dennis P. Pollow, Caitlin Moffett, Wendy Nunez, Jennifer L. Uhrlaub, Janko Nikolich-Zugich, Heddwen L. Brooks

Publikováno v: Am J Physiol Renal Physiol

Premenopausal females are protected from angiotensin II (ANG II)-induced hypertension following the adoptive transfer of T cells from normotensive donors. For the present study, we hypothesized that the transfer of hypertensive T cells (HT) or spleno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb69abf604b0d22d5ecceebc23e59b44
https://pubmed.ncbi.nlm.nih.gov/35001661

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Using 4-vinylcyclohexene diepoxide as a model of menopause for cardiovascular disease

Autor: Jessica N Sanchez, Danielle K. Cannon, Hao Chen, Yulia Lipovka, Dennis P Pollow, Eleni Constantopoulos, Jessica A. Regan, John P. Konhilas, Rinku Skaria, Laurel A. McKee, Marissa A. Lopez-Pier, Heddwen L. Brooks

Publikováno v: Am J Physiol Heart Circ Physiol

There is a sharp rise in cardiovascular disease (CVD) risk and progression with the onset of menopause. The 4-vinylcyclohexene diepoxide (VCD) model of menopause recapitulates the natural, physiological transition through perimenopause to menopause.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf946530994ca83af4f7be95c1ef8ed
https://doi.org/10.1152/ajpheart.00555.2019

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