Key role of a structural water molecule for the specificity of 14F7—An antitumor antibody targeting the NeuGc GM3 ganglioside

Autor: Ernesto Moreno, Kaare Bjerregaard-Andersen, Fana Abraha, Stefan Oscarson, Ute Krengel, Hedda Johannesen

Publikováno v: Glycobiology

Tumor-associated glycolipids such as NeuGc GM3 are auspicious molecular targets in antineoplastic therapies and vaccine strategies. 14F7 is a monoclonal IgG1 with high clinical potential in cancer immunotherapy as it displays extraordinary specificit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f23c890814c1cb919fd98444f7ee5d
https://doi.org/10.1093/glycob/cwab076

Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture

Autor: Ute Krengel, Helene Mykland Hoås, Gertrudis Rojas, Lene Støkken Høydahl, Daniel Burschowsky, Fana Abraha, Julie Elisabeth Heggelund, Paula A. Bousquet, Hedda Johannesen, Noha Abdel-Rahman, Geir Åge Løset, Kaare Bjerregaard-Andersen, Stefan Oscarson

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
'Scientific Reports ', vol: 8, pages: 10836-1-10836-11 (2018)
Scientific Reports

Targeted cancer immunotherapy offers increased efficacy concomitantly with reduced side effects. One antibody with promising clinical potential is 14F7, which specifically recognises the NeuGc GM3 ganglioside. This antigen is found in the plasma memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b911914b6302a0c0371903aa3bce4b68
http://link.springer.com/article/10.1038/s41598-018-28918-5